Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Sarcoma because of DICER1 and NF2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Birch and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Sarcoma from cBioPortal. From a patient sample size of 50; the top genes with mutations and other abnormalities for Uterine Sarcoma include genes DICER1, ARID1A, NF2, IRF4 and INSR. The occurrence frequency distribution for these genes respectively is 30.0%, 20.0%, 10.0%, 10.0% and 10.0%. These tumor genetic details of Uterine Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Sarcoma.
Uterine sarcoma is a rare and aggressive form of cancer that affects the smooth muscle and connective tissue of the uterus. It is usually diagnosed in postmenopausal women and is often misdiagnosed as fibroids or leiomyosarcoma. Symptoms of uterine sarcoma include unusual bleeding, pain, and a feeling of being full. The stage of uterine sarcoma is determined by the size of the tumor and its spread to surrounding tissues and organs. Stage I cancer is localized to the uterus only; Stage II has spread to the pelvis beyond the uterus; Stage III has spread to areas in the abdomen outside the pelvis, including lymph nodes; and Stage IV cancer has spread to distant areas outside the abdomen. The recurrence rate of uterine sarcoma is high, and the life expectancy for patients with advanced stages of the disease is often poor. However, early diagnosis and prompt treatment can improve the chances of survival for uterine sarcoma patients. In some cases, surgery may be the best option for removing the tumor, but the success of the procedure depends on the stage and location of the sarcoma. Despite the challenges, there are many uterine sarcoma survivors who have overcome the disease and are living full, healthy lives. Supportive care with optimal nutrition (foods and natural supplements) can help with improving well-being of the patients diagnosed with uterine sarcoma. (Ref: https://www.cancer.org/cancer/uterine-sarcoma/detection-diagnosis-staging/signs-symptoms.html; https://www.cancer.gov/types/uterine/hp/uterine-sarcoma-treatment-pdq; https://my.clevelandclinic.org/health/diseases/16408-uterine-sarcoma)
Significance of Nutrition for Uterine Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Resveratrol, Hyperoside, Quercetin, Vitamin C and others. And Persimmon contains active ingredients Lycopene, Betulinic Acid, Lupeol, Quercetin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Sarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, PI3K-AKT-MTOR Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Sarcoma undergoing chemotherapy treatment
In Uterine Sarcoma – the genes DICER1, ARID1A, NF2, IRF4 and INSR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Sarcoma are Cell Cycle Checkpoints, Apoptosis, Epithelial to Mesenchymal Transition and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Pelargonidin has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. And so on.
When treating Uterine Sarcoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Pelargonidin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR UTERINE SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Carob?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Phloroglucinol, Palmitic Acid, Gallic Acid and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Kaempferol has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
When treating Uterine Sarcoma with chemotherapy Doxorubicin – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR UTERINE SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lycopene, Betulinic Acid, Lupeol, Quercetin, Vitamin C among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Hyperoside, Quercetin, Vitamin C and others.
Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
When treating Uterine Sarcoma with chemotherapy Doxorubicin – Foods like Persimmon are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER CRANBERRY FOR UTERINE SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Beta-sitosterol, Quercetin, Vitamin C, Beta-carotene, Quercitrin and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
When treating Uterine Sarcoma with chemotherapy Doxorubicin – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR UTERINE SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DICER1 and NF2 are two genes whose abnormalities are risk factors for Uterine Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Sarcoma gene DICER1 has causative impact on biological pathways like NFKB Signaling and Apoptosis. And NF2 has a causative impact on biological pathways like Hippo Signaling, Cytoskeletal Dynamics and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DICER1 and NF2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DICER1 and NF2 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Genistein, Linoleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Sarcoma due to abnormalities in genes DICER1 and NF2 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF UTERINE SARCOMA DUE TO GENES DICER1 AND NF2
Eat more vegetables, Giant Butterbur or Jute?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Jute are Vitamin C, Quercetin, Oleic Acid, Linolenic Acid, Vitamin B3 and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Uterine Sarcoma due to abnormalities in genes DICER1 and NF2 – Foods like Giant Butterbur are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF UTERINE SARCOMA DUE TO GENES DICER1 AND NF2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, Quercetin, P-coumaric Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Uterine Sarcoma due to abnormalities in genes DICER1 and NF2 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF UTERINE SARCOMA DUE TO GENES DICER1 AND NF2
Eat more nuts, Pine Nut or Brazil Nut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linoleic Acid, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Uterine Sarcoma due to abnormalities in genes DICER1 and NF2 – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF UTERINE SARCOMA DUE TO GENES DICER1 AND NF2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.
- Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- Research progress on the anticancer effects of vitamin K2.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.