Foods for Solid Pseudopapillary Neoplasm Of The Pancreas!

Introduction

Foods for Solid Pseudopapillary Neoplasm Of The Pancreas should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Solid Pseudopapillary Neoplasm (SPN) of the pancreas is a rare tumor characterized by unique pathology outlines and histology, often presenting as a well-circumscribed mass in the pancreatic head. This neoplasm, also known as solid pseudopapillary epithelial neoplasm, can be diagnosed through various imaging techniques, including CT, MRI, and radiology, with Radiopaedia providing detailed insights. The ICD-10 coding for pancreatic solid pseudopapillary neoplasm aids in its classification and tracking in medical records. SPN’s treatment typically involves surgical resection, and while it’s considered low-grade malignant, there’s a potential for metastasis. Symptoms can be non-specific, making early detection challenging. Immunohistochemistry is crucial for diagnosis, particularly the staining for beta-catenin. While SPNs are predominantly found in the pancreas, similar neoplasms can occur in the ovary, underscoring the importance of understanding their pathology in different organ systems. The prognosis of SPN is generally favorable, especially when detected early and treated appropriately, and ongoing research focuses on clarifying its malignant potential and optimal management strategies.

For Solid Pseudopapillary Neoplasm Of The Pancreas does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Solid Pseudopapillary Neoplasm Of The Pancreas does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Solid Pseudopapillary Neoplasm Of The Pancreas?

For example does it matter if vegetable Okra is consumed more compared to Chinese Broccoli? Does it make any difference if fruit Natal Plum is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Butternut over Japanese Walnut and for pulses like Moth Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Solid Pseudopapillary Neoplasm Of The Pancreas and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Solid Pseudopapillary Neoplasm Of The Pancreas!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Natal Plum contains active ingredients Caffeine, Lupeol, Beta-sitosterol, Daidzein, Phloretin. And Pomegranate contains active ingredients Quercetin, Lupeol, Naringin, Beta-sitosterol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Solid Pseudopapillary Neoplasm Of The Pancreas – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Solid Pseudopapillary Neoplasm Of The Pancreas.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Solid Pseudopapillary Neoplasm Of The Pancreas?

Personalized nutrition for cancers like Solid Pseudopapillary Neoplasm Of The Pancreas consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Solid Pseudopapillary Neoplasm Of The Pancreas biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Solid Pseudopapillary Neoplasm Of The Pancreas

All cancers like Solid Pseudopapillary Neoplasm Of The Pancreas can be characterized by a unique set of biochemical pathways – the signature pathways of Solid Pseudopapillary Neoplasm Of The Pancreas. Biochemical pathways like Cell Cycle, Cytoskeletal Dynamics, Epithelial to Mesenchymal Transition, DNA Repair are part of the signature definition of Solid Pseudopapillary Neoplasm Of The Pancreas. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Solid Pseudopapillary Neoplasm Of The Pancreas need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

CTNNB1, FAT4, ATP2B3, GRM4 and GRM6 are the top ranked reported genes for Solid Pseudopapillary Neoplasm Of The Pancreas. CTNNB1 is reported in 57.1 % of the representative patients across all clinical trials. And FAT4 is reported in 14.3 %. The combined population patient data cover ages from 58 to 58. 11.4 % of the patient data are identified as men. The Solid Pseudopapillary Neoplasm Of The Pancreas biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Solid Pseudopapillary Neoplasm Of The Pancreas

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable OKRA or CHINESE BROCCOLI?

Vegetable Okra contains many active ingredients or bioactives such as Quercetin, Lupeol, Beta-sitosterol, Daidzein, Eugenol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Okra is recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation. This is because Okra modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Lupeol, Beta-sitosterol, Daidzein, Phloretin, Eugenol. These active ingredients manipulate various biochemical pathways like DNA Repair and Cytoskeletal Dynamics and others. Chinese Broccoli is not recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE OKRA IS RECOMMENDED OVER CHINESE BROCCOLI FOR Solid Pseudopapillary Neoplasm Of The Pancreas AND TREATMENT Radiation.

Choose Fruit POMEGRANATE or NATAL PLUM?

Fruit Pomegranate contains many active ingredients or bioactives such as Quercetin, Lupeol, Naringin, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Pomegranate is recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Natal Plum are Caffeine, Lupeol, Beta-sitosterol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and Cytoskeletal Dynamics and others. Natal Plum is not recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER NATAL PLUM FOR Solid Pseudopapillary Neoplasm Of The Pancreas AND TREATMENT Radiation.

Choose Nut BUTTERNUT or JAPANESE WALNUT?

Butternut contains many active ingredients or bioactives such as Caffeine, Lupeol, Beta-sitosterol, Daidzein, Eugenol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle and Epithelial to Mesenchymal Transition and others. Butternut is recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Japanese Walnut are Caffeine, Lupeol, Beta-sitosterol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics and others. Japanese Walnut is not recommended for Solid Pseudopapillary Neoplasm Of The Pancreas when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER JAPANESE WALNUT FOR Solid Pseudopapillary Neoplasm Of The Pancreas AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Solid Pseudopapillary Neoplasm Of The Pancreas or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable NEW ZEALAND SPINACH or CUCURBITA?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Beta-sitosterol, Quercetin. These active ingredients manipulate various biochemical pathways like Adherens junction, CDH2 Signaling, P53 Signaling and Epithelial to Mesenchymal Transition and others. New Zealand Spinach is recommended for risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3. This is because New Zealand Spinach increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cucurbita are Curcumin, Phloretin, Beta-sitosterol, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and others. Cucurbita is not recommended when risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER CUCURBITA FOR ATP2B3 GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or LONGAN?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Beta-sitosterol, Lupeol. These active ingredients manipulate various biochemical pathways like Adherens junction, CDH2 Signaling, GNAI Signaling and Focal Adhesion and others. Java Plum is recommended for risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Longan are Curcumin, Apigenin, Phloretin, Beta-sitosterol, Lupeol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and Small Molecule Transport and others. Longan is not recommended when risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER LONGAN FOR ATP2B3 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or WALNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Phloretin, Beta-sitosterol, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like Adherens junction, CDH2 Signaling, P53 Signaling and Epithelial to Mesenchymal Transition and others. Common Walnut is recommended for risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Walnut are Curcumin, Apigenin, Phloretin, D-limonene, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Small Molecule Transport and others. Walnut is not recommended when risk of Solid Pseudopapillary Neoplasm Of The Pancreas when associated genetic risk is ATP2B3 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER WALNUT FOR ATP2B3 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Solid Pseudopapillary Neoplasm Of The Pancreas. Solid Pseudopapillary Neoplasm Of The Pancreas patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Solid Pseudopapillary Neoplasm Of The Pancreas, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Okra contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Solid Pseudopapillary Neoplasm Of The Pancreas?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Integrative clinical genomics of metastatic cancer.
• β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
• Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity.
• Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Research progress on the anticancer effects of vitamin K2.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter.