Which Foods are Recommended for Rhabdoid Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Rhabdoid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Rhabdoid Cancer because of SMARCB1 and MUC4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Rhabdoid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Lettuce” or “Can I take Agaricus Mushroom and Sumac supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RHABDOID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Rhabdoid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR RHABDOID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Rhabdoid Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Rhabdoid Cancer from cBioPortal. The patients enrolled in the studies for Rhabdoid Cancer are in ages between 2 to 15 with an average age of 3. 52.2% of males and 47.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 112; the top genes with mutations and other abnormalities for Rhabdoid Cancer include genes SMARCB1, MUC4, NOTCH2, AFF4 and ARHGAP5. The occurrence frequency distribution for these genes respectively is 20.0%, 5.0%, 5.0%, 2.5% and 2.5%. These tumor genetic details of Rhabdoid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Rhabdoid Cancer.

Significance of Nutrition for Rhabdoid Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Rhabdoid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Coconut includes active ingredients Vitamin E, Beta-sitosterol, Palmitic Acid, Capric Acid, Myristic Acid and others. And Blackberry contains active ingredients Quercetin, Myricetin, Ellagic Acid, Gallic Acid, Kaempferol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Rhabdoid Cancer, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Notch Signaling, Chromatin Remodeling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Rhabdoid Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RHABDOID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Rhabdoid Cancer undergoing chemotherapy treatment

In Rhabdoid Cancer – the genes SMARCB1, MUC4, NOTCH2, AFF4 and ARHGAP5 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Rhabdoid Cancer are Cytoskeletal Dynamics, Notch Signaling, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Notch Signaling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Kaempferol, Genistein, Lupeol among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Ferulic Acid, Vitamin C, Astragalin, Palmitic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Vitamin A has biological action on biochemical pathways Notch Signaling. And so on.

When treating Rhabdoid Cancer with chemotherapy Radiation – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Vitamin A in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR RHABDOID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Lettuce?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Vanillic Acid, Chlorogenic Acid, Protocatechuic Acid, Beta-carotene among others. While the active ingredients contained in Lettuce are Quercetin, Linolenic Acid, Chlorogenic Acid, Beta-sitosterol, Glucaric Acid and others.

Quercetin can manipulate biochemical pathways NFKB Signaling, DNA Repair and Notch Signaling. Vanillic Acid has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Rhabdoid Cancer with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Lettuce. This is because the active ingredients Vitamin A and Oleic Acid in Lettuce interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vanillic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER LETTUCE FOR RHABDOID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Blackberry or Coconut?

Fruits are an important part of many diets. The active ingredients contained in Blackberry are Quercetin, Myricetin, Ellagic Acid, Gallic Acid, Kaempferol among others. While the active ingredients contained in Coconut are Vitamin E, Beta-sitosterol, Palmitic Acid, Capric Acid, Myristic Acid and others.

Cianidanol can manipulate biochemical pathways NFKB Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Scopoletin has biological action on biochemical pathways NFKB Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and NFKB Signaling. And so on.

When treating Rhabdoid Cancer with chemotherapy Radiation – Foods like Blackberry are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Lauric Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Scopoletin contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER COCONUT FOR RHABDOID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Folic Acid, Lecithin and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways Notch Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, PI3K-AKT-MTOR Signaling and Cytoskeletal Dynamics. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Rhabdoid Cancer with chemotherapy Radiation – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR RHABDOID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Rhabdoid Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCB1 and MUC4 are two genes whose abnormalities are risk factors for Rhabdoid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Rhabdoid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Rhabdoid Cancer gene SMARCB1 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And MUC4 has a causative impact on biological pathways like Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCB1 and MUC4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCB1 and MUC4 should be avoided.

Eat more pulses, Mung Bean or Moth Bean?

The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Vitamin C, Vitexin, Linolenic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Rhabdoid Cancer due to abnormalities in genes SMARCB1 and MUC4 – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF RHABDOID CANCER DUE TO GENES SMARCB1 AND MUC4

Eat more vegetables, Arugula or Jute?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin B3 and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Rhabdoid Cancer due to abnormalities in genes SMARCB1 and MUC4 – Foods like Arugula are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF RHABDOID CANCER DUE TO GENES SMARCB1 AND MUC4

Eat more fruits, Feijoa or Peach?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Rhabdoid Cancer due to abnormalities in genes SMARCB1 and MUC4 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF RHABDOID CANCER DUE TO GENES SMARCB1 AND MUC4

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Rhabdoid Cancer due to abnormalities in genes SMARCB1 and MUC4 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF RHABDOID CANCER DUE TO GENES SMARCB1 AND MUC4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Rhabdoid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Rt Target 2018 Pub
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