Foods for Rhabdoid Cancer!

Introduction

Foods for Rhabdoid Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Rhabdoid tumor is a highly aggressive and rare form of cancer that can affect various parts of the body. Symptoms of rhabdoid cancer can vary depending on the location and extent of the tumor. Survival rates for rhabdoid cancer depend on multiple factors, including the stage of the cancer and the effectiveness of treatment. While rhabdoid tumors are commonly associated with pediatric cases, they can also occur in adults. Diagnosis and treatment options differ based on the specific characteristics of rhabdoid cancer in adults and babies. Stage 4 rhabdoid cancer indicates advanced disease, and life expectancy can be affected. Rhabdoid cancer is characterized by the presence of unique cancer cells known as rhabdoid cells. Understanding the features and behaviors of rhabdoid tumors is essential for accurate diagnosis and treatment planning. Raising awareness about this rare cancer and its specific type aids in supporting research and promoting patient care. While rhabdoid lung and breast cancers are less common, they require specialized management approaches. Through ongoing research and advancements in treatment, efforts are made to improve outcomes and quality of life for individuals affected by rhabdoid cancer.

For Rhabdoid Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Rhabdoid Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Rhabdoid Cancer?

For example does it matter if vegetable Cauliflower is consumed more compared to Common Beet? Does it make any difference if fruit Pummelo is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Black-eyed Pea over Chickpea. And if what I eat matters – then how does one identify foods which are recommended for Rhabdoid Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Rhabdoid Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Isoliquiritigenin, Daidzein, Lycopene. And Evergreen Blackberry contains active ingredients Myricetin, Ellagic Acid, Cinnamaldehyde, Methyleugenol, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Rhabdoid Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Rhabdoid Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Rhabdoid Cancer?

Personalized nutrition for cancers like Rhabdoid Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Rhabdoid Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Rhabdoid Cancer

All cancers like Rhabdoid Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Rhabdoid Cancer. Biochemical pathways like Cytoskeletal Dynamics, Angiogenesis, Chromatin Remodeling, Notch Signaling are part of the signature definition of Rhabdoid Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Rhabdoid Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Rhabdoid Cancer when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

SMARCB1, MUC4, NOTCH2, AFF4 and ARHGAP5 are the top ranked reported genes for Rhabdoid Cancer. SMARCB1 is reported in 20.0 % of the representative patients across all clinical trials. And MUC4 is reported in 5.0 %. The combined population patient data cover ages from 2 to 15. 52.2 % of the patient data are identified as men. The Rhabdoid Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Rhabdoid Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or COMMON BEET?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Daidzein, Cinnamaldehyde, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling and NFKB Signaling and others. Cauliflower is recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Common Beet are Myricetin, Curcumin, Isoliquiritigenin, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Common Beet is not recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER COMMON BEET FOR Rhabdoid Cancer AND TREATMENT Radiation.

Choose Fruit EVERGREEN BLACKBERRY or PUMMELO?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Myricetin, Ellagic Acid, Cinnamaldehyde, Methyleugenol, Linalool. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling and NFKB Signaling and others. Evergreen Blackberry is recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Isoliquiritigenin, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER PUMMELO FOR Rhabdoid Cancer AND TREATMENT Radiation.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Quercetin, Myricetin, Curcumin, Ellagic Acid, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling and NFKB Signaling and others. Black Walnut is recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Myricetin, Curcumin, Ellagic Acid, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like DNA Repair and Cytoskeletal Dynamics and others. European Chestnut is not recommended for Rhabdoid Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Rhabdoid Cancer AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Rhabdoid Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or ASPARAGUS?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Small Molecule Transport and MYC Signaling and others. Giant Butterbur is recommended for risk of Rhabdoid Cancer when associated genetic risk is AFF4. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Asparagus are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and others. Asparagus is not recommended when risk of Rhabdoid Cancer when associated genetic risk is AFF4 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ASPARAGUS FOR AFF4 GENETIC RISK OF CANCER.

Choose Fruit NANCE or BLACK ELDERBERRY?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Small Molecule Transport and MYC Signaling and others. Nance is recommended for risk of Rhabdoid Cancer when associated genetic risk is AFF4. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Black Elderberry are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and Small Molecule Transport and others. Black Elderberry is not recommended when risk of Rhabdoid Cancer when associated genetic risk is AFF4 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER BLACK ELDERBERRY FOR AFF4 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or PUMPKIN SEEDS?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Small Molecule Transport and MYC Signaling and others. Common Hazelnut is recommended for risk of Rhabdoid Cancer when associated genetic risk is AFF4. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Gamma-linolenic Acid. These active ingredients manipulate various biochemical pathways like Angiogenesis and PI3K-AKT-MTOR Signaling and others. Pumpkin Seeds is not recommended when risk of Rhabdoid Cancer when associated genetic risk is AFF4 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR AFF4 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Rhabdoid Cancer. Rhabdoid Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Rhabdoid Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Rhabdoid Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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