Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Renal Medullary Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Renal Medullary Carcinoma because of DICER1 and MAP3K1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Renal Medullary Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Star Fruit” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Taro” or “Can I take Resveratrol and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RENAL MEDULLARY CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Renal Medullary Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR RENAL MEDULLARY CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Renal Medullary Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Renal Medullary Carcinoma from cBioPortal. 40.0% of males and 60.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Renal Medullary Carcinoma include genes DICER1, MAP3K1, NCOA3, PPARG and PRDM1. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Renal Medullary Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Renal Medullary Carcinoma.
Significance of Nutrition for Renal Medullary Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Renal Medullary Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Star Fruit includes active ingredients Oleic Acid, Beta-sitosterol, Vitamin C, Linoleic Acid, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Renal Medullary Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Renal Medullary Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RENAL MEDULLARY CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Renal Medullary Carcinoma undergoing chemotherapy treatment
In Renal Medullary Carcinoma – the genes DICER1, MAP3K1, NCOA3, PPARG and PRDM1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Renal Medullary Carcinoma are Cell Cycle, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Bean or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Bean are Apigenin, Genistein, Oleic Acid, Gamma-linolenic Acid, Vitamin C among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Vitamin C, Butyric Acid, Ferulic Acid, Vitamin A and others.
Vitamin A can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle.
Palmitic Acid can manipulate biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Renal Medullary Carcinoma with chemotherapy Radiation – Foods like Common Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Apigenin contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR RENAL MEDULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Taro?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Isorhamnetin among others. While the active ingredients contained in Taro are Oleic Acid, Beta-sitosterol, Vitamin C, Linoleic Acid, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle. Vitamin C has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Renal Medullary Carcinoma with chemotherapy Radiation – Foods like Asparagus are recommended compared to Taro. This is because the active ingredients Linoleic Acid and Folic Acid in Taro interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER TARO FOR RENAL MEDULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Star Fruit?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Star Fruit are Oleic Acid, Beta-sitosterol, Vitamin C, Linoleic Acid, Linolenic Acid and others.
Resveratrol can manipulate biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Renal Medullary Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Star Fruit. This is because the active ingredients Linoleic Acid and Folic Acid in Star Fruit interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER STAR FRUIT FOR RENAL MEDULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Oleic Acid, Beta-sitosterol, Vitamin E, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Folic Acid, Lecithin and others.
Beta-sitosterol can manipulate biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle. Resveratrol has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Cell Cycle.
Lecithin can manipulate biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Renal Medullary Carcinoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR RENAL MEDULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Renal Medullary Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DICER1 and MAP3K1 are two genes whose abnormalities are risk factors for Renal Medullary Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Renal Medullary Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Renal Medullary Carcinoma gene DICER1 has causative impact on biological pathways like NFKB Signaling and Apoptosis. And MAP3K1 has a causative impact on biological pathways like MAPK Signaling, Angiogenesis and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DICER1 and MAP3K1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DICER1 and MAP3K1 should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Quercetin, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Renal Medullary Carcinoma due to abnormalities in genes DICER1 and MAP3K1 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF RENAL MEDULLARY CARCINOMA DUE TO GENES DICER1 AND MAP3K1
Eat more vegetables, Jicama or Bell Pepper?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Oleic Acid, Linolenic Acid, Vitamin C, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Renal Medullary Carcinoma due to abnormalities in genes DICER1 and MAP3K1 – Foods like Jicama are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF RENAL MEDULLARY CARCINOMA DUE TO GENES DICER1 AND MAP3K1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Strawberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Cianidanol, Beta-sitosterol, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Renal Medullary Carcinoma due to abnormalities in genes DICER1 and MAP3K1 – Foods like Kiwi are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF RENAL MEDULLARY CARCINOMA DUE TO GENES DICER1 AND MAP3K1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Renal Medullary Carcinoma due to abnormalities in genes DICER1 and MAP3K1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF RENAL MEDULLARY CARCINOMA DUE TO GENES DICER1 AND MAP3K1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Renal Medullary Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mixed Kunga Msk 2022
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Small-molecule inhibitors of NADPH oxidase 4.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
- Research progress on the anticancer effects of vitamin K2.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.