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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Schwannoma?

Aug 9, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Schwannoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Schwannoma because of NF2 and PRKAR1A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Schwannoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Senna and Vitamin E supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SCHWANNOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Schwannoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SCHWANNOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Schwannoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Schwannoma from cBioPortal. The patients enrolled in the studies for Schwannoma are in ages between 11 to 88 with an average age of 41. 38.9% of males and 61.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 54; the top genes with mutations and other abnormalities for Schwannoma include genes PPM1D, NF2, ASXL1, PRKAR1A and BRCA1. The occurrence frequency distribution for these genes respectively is 27.3%, 18.2%, 9.1%, 9.1% and 9.1%. These tumor genetic details of Schwannoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Schwannoma.

Significance of Nutrition for Schwannoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Schwannoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Lupeol, Psoralen, Vitamin C, Beta-sitosterol, Bergapten and others. And Pomegranate contains active ingredients Vitamin C, Betulinic Acid, Beta-sitosterol, Corilagin, Maslinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Schwannoma, activation or inhibition of selected biochemical pathways like DNA Repair, Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints, Suppressive Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Schwannoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Schwannoma, activation or inhibition of selected biochemical pathways like DNA Repair, Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints, Suppressive Histone Methylation plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SCHWANNOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Schwannoma undergoing chemotherapy treatment

In Schwannoma – the genes PPM1D, NF2, ASXL1, PRKAR1A and BRCA1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Schwannoma are DNA Repair and others. Trametinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Quercetin, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Ferulic Acid, Vitamin C, Daidzein, Quercetin, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling. Quercetin has biological action on biochemical pathways DNA Repair and MYC Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Schwannoma with chemotherapy Trametinib – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Genistein and Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR SCHWANNOMA ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Vitamin C, Quercetin, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Schwannoma with chemotherapy Trametinib – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR SCHWANNOMA ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.

Which Foods are Recommended for Schwannoma?

Eat more fruits, Pomegranate or Fig?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Vitamin C, Betulinic Acid, Beta-sitosterol, Corilagin, Maslinic Acid among others. While the active ingredients contained in Fig are Lupeol, Psoralen, Vitamin C, Beta-sitosterol, Bergapten and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling. Casuarinin has biological action on biochemical pathways MYC Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Schwannoma with chemotherapy Trametinib – Foods like Pomegranate are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Casuarinin contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER FIG FOR SCHWANNOMA ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Walnut are Vitamin E, Protocatechuic Acid, Betulinic Acid, Vitamin C, Hyperoside and others.

Vitamin E can manipulate biochemical pathways MYC Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways MYC Signaling.

Juglone can manipulate biochemical pathways DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Schwannoma with chemotherapy Trametinib – Foods like Pecan Nut are recommended compared to Walnut. This is because the active ingredients Juglone and Ellagic Acid in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER WALNUT FOR SCHWANNOMA ON TREATMENT WITH CHEMOTHERAPY TRAMETINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Schwannoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NF2 and PRKAR1A are two genes whose abnormalities are risk factors for Schwannoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Schwannoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Schwannoma gene NF2 has causative impact on biological pathways like Hippo Signaling, Cytoskeletal Dynamics and Growth Factor Signaling. And PRKAR1A has a causative impact on biological pathways like Cannabinoid receptor Signaling and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NF2 and PRKAR1A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NF2 and PRKAR1A should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Vitamin E and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Schwannoma due to abnormalities in genes NF2 and PRKAR1A – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF SCHWANNOMA DUE TO GENES NF2 AND PRKAR1A

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Oleic Acid, Linolenic Acid, Cynaroside and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Schwannoma due to abnormalities in genes NF2 and PRKAR1A – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF SCHWANNOMA DUE TO GENES NF2 AND PRKAR1A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Raspberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Resveratrol, Vitamin C, Ellagic Acid, Quercetin, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Schwannoma due to abnormalities in genes NF2 and PRKAR1A – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF SCHWANNOMA DUE TO GENES NF2 AND PRKAR1A

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin C, Vitamin E, Oleic Acid, Linolenic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Schwannoma due to abnormalities in genes NF2 and PRKAR1A – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SCHWANNOMA DUE TO GENES NF2 AND PRKAR1A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Schwannoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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