Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Embryonal Rhabdomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Embryonal Rhabdomyosarcoma because of NRAS and DICER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Embryonal Rhabdomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Turmeric and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EMBRYONAL RHABDOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Embryonal Rhabdomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR EMBRYONAL RHABDOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Embryonal Rhabdomyosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Embryonal Rhabdomyosarcoma from cBioPortal. The patients enrolled in the studies for Embryonal Rhabdomyosarcoma are in ages between 1 to 25 with an average age of 9. 53.7% of males and 46.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 95; the top genes with mutations and other abnormalities for Embryonal Rhabdomyosarcoma include genes NRAS, DICER1, FGFR4, TP53 and BCOR. The occurrence frequency distribution for these genes respectively is 17.5%, 12.5%, 10.0%, 10.0% and 10.0%. These tumor genetic details of Embryonal Rhabdomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Embryonal Rhabdomyosarcoma.
Embryonal rhabdomyosarcoma is the most common type of rhabdomyosarcoma, a rare cancer that affects muscle tissue. It is most common in children and adolescents but can also occur in adults and has a poorer prognosis than in children. Rhabdomyosarcoma can occur anywhere in the body, but embryonal rhabdomyosarcoma usually occurs in the head and neck or the reproductive and urinary organs. Symptoms of rhabdomyosarcoma can vary based on the location of the tumor, but common symptoms include bleeding from the nose, throat, vagina, or rectum, blood in the urine and trouble with urinating or bowel movements, headaches, lump that grows in size. The 5-year survival rate for patients with rhabdomyosarcoma is around 70%, but the prognosis can vary based on multiple factors that include the type of rhabdomyosarcoma, stage of the disease, location and size of the tumor, success of the treatment, whether the tumor has spread and the age of the patient. Treatment for rhabdomyosarcoma include surgery, chemotherapy, radiation therapy and supportive care. The right nutrition (foods and natural supplements) can help improve the patients’ well-being. (Ref: https://my.clevelandclinic.org/health/diseases/6226-rhabdomyosarcoma; Chen J et al, Int J Womens Health, 2022; https://www.mayoclinic.org/diseases-conditions/rhabdomyosarcoma/symptoms-causes/syc-20390962)
Significance of Nutrition for Embryonal Rhabdomyosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Embryonal Rhabdomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Beta-sitosterol, Naringin, Vitamin C, Oleic Acid, Linolenic Acid and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Hesperidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Embryonal Rhabdomyosarcoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Embryonal Rhabdomyosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EMBRYONAL RHABDOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Embryonal Rhabdomyosarcoma undergoing chemotherapy treatment
In Embryonal Rhabdomyosarcoma – the genes NRAS, DICER1, FGFR4, TP53 and BCOR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Embryonal Rhabdomyosarcoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling, Growth Factor Signaling and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Daidzein, Lupeol, Quercetin, Beta-sitosterol, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways Chromatin Remodeling and DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Embryonal Rhabdomyosarcoma with chemotherapy Pembrolizumab – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR EMBRYONAL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Protocatechuic Acid, Quercetin, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid and others.
Protocatechuic Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, Growth Factor Signaling and WNT Beta Catenin Signaling.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.
When treating Embryonal Rhabdomyosarcoma with chemotherapy Pembrolizumab – Foods like Arrowroot are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Protocatechuic Acid and Quercetin contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER CELERY FOR EMBRYONAL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Orange or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Hesperidin among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Naringin, Vitamin C, Oleic Acid, Linolenic Acid and others.
D-limonene can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.
Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Embryonal Rhabdomyosarcoma with chemotherapy Pembrolizumab – Foods like Orange are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER PUMMELO FOR EMBRYONAL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin C, Ferulic Acid, Vitamin E and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways DNA Repair. And so on.
When treating Embryonal Rhabdomyosarcoma with chemotherapy Pembrolizumab – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR EMBRYONAL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Embryonal Rhabdomyosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NRAS and DICER1 are two genes whose abnormalities are risk factors for Embryonal Rhabdomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Embryonal Rhabdomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Embryonal Rhabdomyosarcoma gene NRAS has causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and RAS-RAF Signaling. And DICER1 has a causative impact on biological pathways like NFKB Signaling and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NRAS and DICER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NRAS and DICER1 should be avoided.
Eat more pulses, Mung Bean or Black-eyed Pea?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Genistein, Linolenic Acid among others. While the active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Oleic Acid, Genistein, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Embryonal Rhabdomyosarcoma due to abnormalities in genes NRAS and DICER1 – Foods like Mung Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Beta-carotene and Vitamin B3 in Black-eyed Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR REDUCING THE GENETIC RISK OF EMBRYONAL RHABDOMYOSARCOMA DUE TO GENES NRAS AND DICER1
Eat more vegetables, Jicama or Jute?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Embryonal Rhabdomyosarcoma due to abnormalities in genes NRAS and DICER1 – Foods like Jicama are recommended compared to Jute. This is because the active ingredients Vitamin B3 and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin A contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF EMBRYONAL RHABDOMYOSARCOMA DUE TO GENES NRAS AND DICER1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Ferulic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Embryonal Rhabdomyosarcoma due to abnormalities in genes NRAS and DICER1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF EMBRYONAL RHABDOMYOSARCOMA DUE TO GENES NRAS AND DICER1
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Quercitrin, Beta-carotene and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Embryonal Rhabdomyosarcoma due to abnormalities in genes NRAS and DICER1 – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin B3 in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF EMBRYONAL RHABDOMYOSARCOMA DUE TO GENES NRAS AND DICER1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Embryonal Rhabdomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.