Which Foods are Recommended for Bladder Adenocarcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Bladder Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Bladder Adenocarcinoma because of ASXL1 and PPM1D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Bladder Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Dim and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BLADDER ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Bladder Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR BLADDER ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Bladder Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Bladder Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Bladder Adenocarcinoma are in ages between 18 to 93 with an average age of 68. 73.5% of males and 26.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 720; the top genes with mutations and other abnormalities for Bladder Adenocarcinoma include genes DNMT3A, TET2, ASXL1, PPM1D and CHEK2. The occurrence frequency distribution for these genes respectively is 31.8%, 12.4%, 8.1%, 7.4% and 4.7%. These tumor genetic details of Bladder Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Bladder Adenocarcinoma.

Significance of Nutrition for Bladder Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Bladder Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Lupeol, Oleic Acid, Protocatechuic Acid, Vitamin C and others. And Raspberry contains active ingredients Quercetin, Ellagic Acid, Resveratrol, Vitamin C, Salicylic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Bladder Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, Suppressive Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Bladder Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BLADDER ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Bladder Adenocarcinoma undergoing chemotherapy treatment

In Bladder Adenocarcinoma – the genes DNMT3A, TET2, ASXL1, PPM1D and CHEK2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Bladder Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Oleic Acid, Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Quercetin, Butein, Oleic Acid, Daidzein, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Bladder Adenocarcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Caffeic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR BLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Bell Pepper?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Bell Pepper are Oleic Acid, Vitamin E, Isorhamnetin, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.

Capsaicin can manipulate biochemical pathways MYC Signaling, DNA Repair and MAPK Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. And so on.

When treating Bladder Adenocarcinoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Vitamin A in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER BELL PEPPER FOR BLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Raspberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Resveratrol, Vitamin C, Salicylic Acid among others. While the active ingredients contained in Date are Quercetin, Lupeol, Oleic Acid, Protocatechuic Acid, Vitamin C and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Bladder Adenocarcinoma with chemotherapy Radiation – Foods like Raspberry are recommended compared to Date. This is because the active ingredients Quercetin and Protocatechuic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER DATE FOR BLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Oleic Acid, Vitamin E, Linolenic Acid, Myricitrin among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Butyric Acid, Lauric Acid and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Myricitrin has biological action on biochemical pathways Microtubule Dynamics, JAK-STAT Signaling and Cell Survival.

Lauric Acid can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Palmitic Acid has biological action on biochemical pathways mRNA Splicing, Extracellular Matrix Remodelling and Microtubule Dynamics. And so on.

When treating Bladder Adenocarcinoma with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Palmitic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR BLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Bladder Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ASXL1 and PPM1D are two genes whose abnormalities are risk factors for Bladder Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Bladder Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Bladder Adenocarcinoma gene ASXL1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. And PPM1D has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ASXL1 and PPM1D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ASXL1 and PPM1D should be avoided.

Eat more pulses, Mung Bean or Common Bean?

The active ingredients contained in Mung Bean are Vitamin C, Stigmasterol, Linolenic Acid, Quercetin, Vitexin among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Bladder Adenocarcinoma due to abnormalities in genes ASXL1 and PPM1D – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF BLADDER ADENOCARCINOMA DUE TO GENES ASXL1 AND PPM1D

Eat more vegetables, Cassava or Heart Of Palm?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and mRNA Splicing. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Bladder Adenocarcinoma due to abnormalities in genes ASXL1 and PPM1D – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF BLADDER ADENOCARCINOMA DUE TO GENES ASXL1 AND PPM1D

Eat more fruits, Feijoa or Graviola?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Graviola are Emodin, Lycopene, Vitamin C, Beta-sitosterol, Daidzein and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.

Fisetin can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Bladder Adenocarcinoma due to abnormalities in genes ASXL1 and PPM1D – Foods like Feijoa are recommended compared to Graviola. This is because the active ingredients Fisetin and Myricetin in Graviola further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAVIOLA FOR REDUCING THE GENETIC RISK OF BLADDER ADENOCARCINOMA DUE TO GENES ASXL1 AND PPM1D

Eat more nuts, Pistachio or Acorn?

The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Vitamin C, Beta-sitosterol, Beta-carotene, Quercetin, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis.

Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Bladder Adenocarcinoma due to abnormalities in genes ASXL1 and PPM1D – Foods like Pistachio are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF BLADDER ADENOCARCINOMA DUE TO GENES ASXL1 AND PPM1D

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Bladder Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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