Foods for Sebaceous Carcinoma!

Introduction

Foods for Sebaceous Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Sebaceous carcinoma is a rare and aggressive form of skin cancer that originates from the sebaceous glands. Pathology outlines provide valuable information on the characteristic features and cellular composition of sebaceous carcinoma tumors. This type of cancer commonly affects the eyelids, and photos can provide visual representations of the condition. Accurate coding using the ICD-10 enables proper classification and documentation of sebaceous carcinoma cases. Timely diagnosis and appropriate treatment are crucial for managing sebaceous carcinoma, and a range of treatment options is available. Symptoms of sebaceous carcinoma may include persistent eyelid swelling, a painless nodule or ulceration, and thickening of the eyelid skin. Survival rates for sebaceous carcinoma can vary depending on the stage and extent of the disease, as well as individual factors. Staging helps determine the spread and progression of the cancer. While sebaceous carcinoma can be aggressive, early detection and treatment can significantly improve outcomes. Breast pathology outlines may provide insights into sebaceous carcinoma that develops in the breast. Cytology studies can aid in the identification of sebaceous carcinoma cells. Curability of sebaceous carcinoma depends on several factors, including the stage and response to treatment. Though sebaceous gland carcinoma is a serious condition, advances in treatment and care have increased the likelihood of successful outcomes. Healthcare professionals should follow treatment guidelines to optimize patient care and improve prognosis.

For Sebaceous Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Sebaceous Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Sebaceous Carcinoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Mexican Groundcherry? Does it make any difference if fruit Grapefruit is preferred over Purple Mangosteen? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Alfalfa over Hyacinth Bean. And if what I eat matters – then how does one identify foods which are recommended for Sebaceous Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Sebaceous Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Catechol, Isoliquiritigenin, Eugenol, Lycopene, Daidzein. And Purple Mangosteen contains active ingredients Catechol, Isoliquiritigenin, Eugenol, Lycopene, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Sebaceous Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Sebaceous Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Sebaceous Carcinoma?

Personalized nutrition for cancers like Sebaceous Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Sebaceous Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Sebaceous Carcinoma

All cancers like Sebaceous Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Sebaceous Carcinoma. Biochemical pathways like Notch Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Suppressive Histone Methylation are part of the signature definition of Sebaceous Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Sebaceous Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Sebaceous Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ASXL1, BAP1, CARD11, CDC73 and CDH1 are the top ranked reported genes for Sebaceous Carcinoma. ASXL1 is reported in 100.0 % of the representative patients across all clinical trials. And BAP1 is reported in 100.0 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Sebaceous Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Sebaceous Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or MEXICAN GROUNDCHERRY?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Catechol, Isoliquiritigenin, Eugenol, Daidzein, Curcumin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Catechol, Isoliquiritigenin, Eugenol, Daidzein, Curcumin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and NFKB Signaling and others. Mexican Groundcherry is not recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR Sebaceous Carcinoma AND TREATMENT Radiation.

Choose Fruit PURPLE MANGOSTEEN or GRAPEFRUIT?

Fruit Purple Mangosteen contains many active ingredients or bioactives such as Catechol, Isoliquiritigenin, Eugenol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and NFKB Signaling and others. Purple Mangosteen is recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation. This is because Purple Mangosteen modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Grapefruit are Catechol, Isoliquiritigenin, Eugenol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like NFKB Signaling and others. Grapefruit is not recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PURPLE MANGOSTEEN IS RECOMMENDED OVER GRAPEFRUIT FOR Sebaceous Carcinoma AND TREATMENT Radiation.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Juglone, Catechol, Isoliquiritigenin, Eugenol, Lycopene. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Catechol, Isoliquiritigenin, Eugenol, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and NFKB Signaling and others. European Chestnut is not recommended for Sebaceous Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Sebaceous Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Sebaceous Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or KOHLRABI?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Adherens junction, Epithelial to Mesenchymal Transition and Stem Cell Signaling and others. Giant Butterbur is recommended for risk of Sebaceous Carcinoma when associated genetic risk is ASXL1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Curcumin, Quercetin, Lupeol, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Kohlrabi is not recommended when risk of Sebaceous Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER KOHLRABI FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Adherens junction, Epithelial to Mesenchymal Transition and Stem Cell Signaling and others. Nance is recommended for risk of Sebaceous Carcinoma when associated genetic risk is ASXL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Quercetin, Apigenin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Sebaceous Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Juglone, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Epithelial to Mesenchymal Transition, Stem Cell Signaling and Adherens junction and others. Common Walnut is recommended for risk of Sebaceous Carcinoma when associated genetic risk is ASXL1. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Lupeol, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Chestnut is not recommended when risk of Sebaceous Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR ASXL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Sebaceous Carcinoma. Sebaceous Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Sebaceous Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Sebaceous Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Access 2021
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• Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition.
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• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.