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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Sebaceous Carcinoma?

Aug 5, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sebaceous Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Sebaceous Carcinoma because of BAP1 and CARD11 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Sebaceous Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Towel Gourd” or “Can I take Mulberry and Resveratrol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SEBACEOUS CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Sebaceous Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SEBACEOUS CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Sebaceous Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Sebaceous Carcinoma from cBioPortal. From a patient sample size of 1; the top genes with mutations and other abnormalities for Sebaceous Carcinoma include genes ASXL1, BAP1, CARD11, CDC73 and CDH1. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Sebaceous Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sebaceous Carcinoma.

Significance of Nutrition for Sebaceous Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sebaceous Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Sapota includes active ingredients Lycopene, Linolenic Acid, Beta-sitosterol, Vitamin C, Gallic Acid and others. And Mulberry contains active ingredients Resveratrol, Morusin, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Sebaceous Carcinoma, activation or inhibition of selected biochemical pathways like Notch Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Suppressive Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sebaceous Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Sebaceous Carcinoma, activation or inhibition of selected biochemical pathways like Notch Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Suppressive Histone Methylation plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SEBACEOUS CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Sebaceous Carcinoma undergoing chemotherapy treatment

In Sebaceous Carcinoma – the genes ASXL1, BAP1, CARD11, CDC73 and CDH1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sebaceous Carcinoma are Notch Signaling, Epithelial to Mesenchymal Transition, NFKB Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Notch Signaling, Epithelial to Mesenchymal Transition, NFKB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Lupeol, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Genistein, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Sebaceous Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR SEBACEOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cucumber or Towel Gourd?

Vegetables are an important part of many diets. The active ingredients contained in Cucumber are Linolenic Acid, Beta-sitosterol, Lupeol, Cucurbitacin E, Vitamin C among others. While the active ingredients contained in Towel Gourd are Vitamin C, Oleic Acid, Vitamin B3, Linoleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin E has biological action on biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Sebaceous Carcinoma with chemotherapy Radiation – Foods like Cucumber are recommended compared to Towel Gourd. This is because the active ingredients Vitamin A and Oleic Acid in Towel Gourd interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Cucurbitacin E contained in Cucumber support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CUCUMBER IS RECOMMENDED OVER TOWEL GOURD FOR SEBACEOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Science of Right Personalized Nutrition for Cancer

Eat more fruits, Mulberry or Sapota?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin among others. While the active ingredients contained in Sapota are Lycopene, Linolenic Acid, Beta-sitosterol, Vitamin C, Gallic Acid and others.

Morusin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and PI3K-AKT-MTOR Signaling. Deoxynojirimycin has biological action on biochemical pathways Epithelial to Mesenchymal Transition.

Vitamin A can manipulate biochemical pathways Notch Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Sebaceous Carcinoma with chemotherapy Radiation – Foods like Mulberry are recommended compared to Sapota. This is because the active ingredients Vitamin A and Oleic Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER SAPOTA FOR SEBACEOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Linolenic Acid, Vitamin E, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Ellagic Acid, Vitamin C, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways Notch Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Vitamin A has biological action on biochemical pathways Notch Signaling. And so on.

When treating Sebaceous Carcinoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR SEBACEOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Sebaceous Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BAP1 and CARD11 are two genes whose abnormalities are risk factors for Sebaceous Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sebaceous Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Sebaceous Carcinoma gene BAP1 has causative impact on biological pathways like DNA Repair. And CARD11 has a causative impact on biological pathways like T-Cell Receptor Signaling and NFKB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BAP1 and CARD11 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BAP1 and CARD11 should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Oleic Acid, Vitamin C, Genistein, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Oleic Acid, Delphinidin, Vitamin C, Genistein and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways NFKB Signaling, DNA Repair and Oncogenic Cancer Epigenetics.

Pelargonidin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Sebaceous Carcinoma due to abnormalities in genes BAP1 and CARD11 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Ferulic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Genistein contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF SEBACEOUS CARCINOMA DUE TO GENES BAP1 AND CARD11

Eat more vegetables, Jicama or Endive?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Beta-carotene, Folic Acid among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Kaempferol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways NFKB Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.

For genetic risk of Sebaceous Carcinoma due to abnormalities in genes BAP1 and CARD11 – Foods like Jicama are recommended compared to Endive. This is because the active ingredients Quercetin and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF SEBACEOUS CARCINOMA DUE TO GENES BAP1 AND CARD11

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Grape or Roselle?

The active ingredients contained in Grape are Resveratrol, Lupeol, Oleic Acid, Delphinidin, Pterostilbene among others. While the active ingredients contained in Roselle are Oleic Acid, Vitamin E, Vitamin C, Linolenic Acid, Stigmasterol and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Vitamin E can manipulate biochemical pathways DNA Repair. Lutein has biological action on biochemical pathways NFKB Signaling. And so on.

For genetic risk of Sebaceous Carcinoma due to abnormalities in genes BAP1 and CARD11 – Foods like Grape are recommended compared to Roselle. This is because the active ingredients Vitamin E and Lutein in Roselle further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Vitamin C contained in Grape together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPE IS RECOMMENDED OVER ROSELLE FOR REDUCING THE GENETIC RISK OF SEBACEOUS CARCINOMA DUE TO GENES BAP1 AND CARD11

Eat more nuts, Pecan Nut or Pumpkin Seeds?

The active ingredients contained in Pecan Nut are Oleic Acid, Delphinidin, Vitamin E, Linolenic Acid, Cianidanol among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Linolenic Acid, Gamma-linolenic Acid, Stigmasterol, Beta-sitosterol and others.

Delphinidin can manipulate biochemical pathways NFKB Signaling, MYC Signaling and MAPK Signaling. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways EPHRIN Signaling, MYC Signaling and NFKB Signaling. And so on.

For genetic risk of Sebaceous Carcinoma due to abnormalities in genes BAP1 and CARD11 – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF SEBACEOUS CARCINOMA DUE TO GENES BAP1 AND CARD11


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Sebaceous Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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