Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Alveolar Soft Part Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Alveolar Soft Part Sarcoma because of SLIT2 and AMER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Alveolar Soft Part Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Elderberry” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Sweet Potato” or “Can I take Baicalin and Beta-sitosterol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ALVEOLAR SOFT PART SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Alveolar Soft Part Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ALVEOLAR SOFT PART SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Alveolar Soft Part Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Alveolar Soft Part Sarcoma from cBioPortal. 55.0% of males and 45.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Alveolar Soft Part Sarcoma include genes SLIT2, AMER1, KEAP1, GRM3 and FOXO1. The occurrence frequency distribution for these genes respectively is 28.6%, 14.3%, 14.3%, 14.3% and 14.3%. These tumor genetic details of Alveolar Soft Part Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Alveolar Soft Part Sarcoma.
Significance of Nutrition for Alveolar Soft Part Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Alveolar Soft Part Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Elderberry includes active ingredients Oleic Acid, Lupeol, Quercetin, Betulinic Acid, Isorhamnetin and others. And Raspberry contains active ingredients Ellagic Acid, Resveratrol, Gallic Acid, Quercetin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Alveolar Soft Part Sarcoma, activation or inhibition of selected biochemical pathways like Oxidative Stress, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Alveolar Soft Part Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ALVEOLAR SOFT PART SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Alveolar Soft Part Sarcoma undergoing chemotherapy treatment
In Alveolar Soft Part Sarcoma – the genes SLIT2, AMER1, KEAP1, GRM3 and FOXO1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Alveolar Soft Part Sarcoma are Oxidative Stress, Inositol Phosphate Signaling, Growth Factor Signaling and others. Axitinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oxidative Stress, Inositol Phosphate Signaling, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Oleic Acid, Lupeol, Beta-sitosterol, Daidzein, Vitamin C among others. While the active ingredients contained in Fava Bean are Caffeic Acid, Oleic Acid, Beta-sitosterol, Daidzein, Butein and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Alveolar Soft Part Sarcoma with chemotherapy Axitinib – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Genistein in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR ALVEOLAR SOFT PART SARCOMA ON TREATMENT WITH CHEMOTHERAPY AXITINIB FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Sweet Potato?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Glucaric Acid, Indole-3-carbinol, Quercetin among others. While the active ingredients contained in Sweet Potato are Oleic Acid, Beta-sitosterol, Quercetin, Vitamin C, Linoleic Acid and others.
Glucaric Acid can manipulate biochemical pathways Inositol Phosphate Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Alveolar Soft Part Sarcoma with chemotherapy Axitinib – Foods like Cabbage are recommended compared to Sweet Potato. This is because the active ingredients Quercetin and Citric Acid in Sweet Potato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SWEET POTATO FOR ALVEOLAR SOFT PART SARCOMA ON TREATMENT WITH CHEMOTHERAPY AXITINIB FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Elderberry?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Gallic Acid, Quercetin, Vitamin C among others. While the active ingredients contained in Elderberry are Oleic Acid, Lupeol, Quercetin, Betulinic Acid, Isorhamnetin and others.
Ellagic Acid can manipulate biochemical pathways Oxidative Stress, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling.
Rutin can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Alveolar Soft Part Sarcoma with chemotherapy Axitinib – Foods like Raspberry are recommended compared to Elderberry. This is because the active ingredients Rutin and Quercetin in Elderberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER ELDERBERRY FOR ALVEOLAR SOFT PART SARCOMA ON TREATMENT WITH CHEMOTHERAPY AXITINIB FOR SOME CONDITIONS.
Eat more nuts, Almond or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Almond are Oleic Acid, Beta-sitosterol, Quercetin, Vitamin E, Vitamin B3 among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Beta-sitosterol, Vitamin B3, Linoleic Acid, Stigmasterol and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Alveolar Soft Part Sarcoma with chemotherapy Axitinib – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin B3 contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR ALVEOLAR SOFT PART SARCOMA ON TREATMENT WITH CHEMOTHERAPY AXITINIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Alveolar Soft Part Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SLIT2 and AMER1 are two genes whose abnormalities are risk factors for Alveolar Soft Part Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Alveolar Soft Part Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Alveolar Soft Part Sarcoma gene SLIT2 has causative impact on biological pathways like Angiogenesis. And AMER1 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SLIT2 and AMER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SLIT2 and AMER1 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Alveolar Soft Part Sarcoma due to abnormalities in genes SLIT2 and AMER1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ALVEOLAR SOFT PART SARCOMA DUE TO GENES SLIT2 AND AMER1
Eat more vegetables, Giant Butterbur or Radish?
The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Radish are Oleic Acid, Vitamin C, Beta-sitosterol, Linolenic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Quercetin can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Alveolar Soft Part Sarcoma due to abnormalities in genes SLIT2 and AMER1 – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Quercetin and Pelargonidin in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF ALVEOLAR SOFT PART SARCOMA DUE TO GENES SLIT2 AND AMER1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Vitamin C, Hyperoside, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Alveolar Soft Part Sarcoma due to abnormalities in genes SLIT2 and AMER1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Quercetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ALVEOLAR SOFT PART SARCOMA DUE TO GENES SLIT2 AND AMER1
Eat more nuts, Pecan Nut or Brazil Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Alveolar Soft Part Sarcoma due to abnormalities in genes SLIT2 and AMER1 – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF ALVEOLAR SOFT PART SARCOMA DUE TO GENES SLIT2 AND AMER1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Alveolar Soft Part Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Compounds structurally related to ellagic acid show improved antiplasmodial activity.
- Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- Research on Rett syndrome: strategy and preliminary results.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.