Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Peritoneal Mesothelioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Peritoneal Mesothelioma because of BAP1 and PPM1D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Peritoneal Mesothelioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Boldo and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PERITONEAL MESOTHELIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Peritoneal Mesothelioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PERITONEAL MESOTHELIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Peritoneal Mesothelioma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Peritoneal Mesothelioma from cBioPortal. The patients enrolled in the studies for Peritoneal Mesothelioma are in ages between 12 to 89 with an average age of 69. 65.8% of males and 34.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 242; the top genes with mutations and other abnormalities for Peritoneal Mesothelioma include genes DNMT3A, TET2, PPM1D, BAP1 and ASXL1. The occurrence frequency distribution for these genes respectively is 25.3%, 10.3%, 8.0%, 5.7% and 5.7%. These tumor genetic details of Peritoneal Mesothelioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Peritoneal Mesothelioma.
Peritoneal mesothelioma is a cancer caused by ingestion or inhalation of asbestos fibers that can become embedded in the lining of the abdomen. Peritoneum is a thin membrane that covers the abdominal cavity and organs including stomach, liver, spleen, and intestines. Peritoneal mesothelioma is the second-most common form of mesothelioma. Symptoms of peritoneal mesothelioma include abdominal pain, bloating and fluid buildup in the abdomen, weight loss and fluid buildup in the abdominal cavity, intestinal obstruction, night sweats. For most patients, early peritoneal mesothelioma symptoms most typically present in the abdomen or gastrointestinal system. Prognosis and life expectancy of peritoneal mesothelioma is more favorable than other types of malignant mesothelioma, ranging from 2-6 years and a 5-year survival rate of 59%. Peritoneal mesothelioma treatment includes a multimodal approach which combines debulking surgery, chemotherapy (hyperthermic intraperitoneal chemotherapy HIPEC), radiation therapy and immunotherapy. In addition, the right nutrition (foods and supplements) personalized to the cancer stage and treatment can help improve patients’ well-being. (Ref: https://www.mesothelioma.com/mesothelioma/types/peritoneal/; https://www.mesotheliomahope.com/mesothelioma/peritoneal/)
Significance of Nutrition for Peritoneal Mesothelioma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Peritoneal Mesothelioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Chlorogenic Acid, Resveratrol, Ferulic Acid, Delphinidin and others. And Orange contains active ingredients Modified Citrus Pectin, D-limonene, Linalool, Linolenic Acid, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Peritoneal Mesothelioma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Peritoneal Mesothelioma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PERITONEAL MESOTHELIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Peritoneal Mesothelioma undergoing chemotherapy treatment
In Peritoneal Mesothelioma – the genes DNMT3A, TET2, PPM1D, BAP1 and ASXL1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Peritoneal Mesothelioma are RAS-RAF Signaling, mRNA Splicing, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Lentils?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Vitamin C, Genistein, Oleic Acid among others. While the active ingredients contained in Lentils are Ellagic Acid, Isoliquiritigenin, Daidzein, Linolenic Acid, Esculin and others.
Quercetin can manipulate biochemical pathways NFKB Signaling, DNA Repair and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Esculin has biological action on biochemical pathways DNA Repair. And so on.
When treating Peritoneal Mesothelioma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Esculin in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LENTILS FOR PERITONEAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Sweet Potato or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Sweet Potato are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Salicylic Acid among others. While the active ingredients contained in Celery are Quercetin, Apigenin, Angelicin, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Peritoneal Mesothelioma with chemotherapy Radiation – Foods like Sweet Potato are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Sweet Potato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SWEET POTATO IS RECOMMENDED OVER CELERY FOR PERITONEAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Orange or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Orange are Modified Citrus Pectin, D-limonene, Linalool, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Huckleberry are Quercetin, Chlorogenic Acid, Resveratrol, Ferulic Acid, Delphinidin and others.
D-limonene can manipulate biochemical pathways NFKB Signaling, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Peritoneal Mesothelioma with chemotherapy Radiation – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR PERITONEAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Salicylic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Vitamin C, Beta-sitosterol, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Quercetin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and MAPK Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Peritoneal Mesothelioma with chemotherapy Radiation – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR PERITONEAL MESOTHELIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Peritoneal Mesothelioma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BAP1 and PPM1D are two genes whose abnormalities are risk factors for Peritoneal Mesothelioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Peritoneal Mesothelioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Peritoneal Mesothelioma gene BAP1 has causative impact on biological pathways like DNA Repair. And PPM1D has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BAP1 and PPM1D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BAP1 and PPM1D should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Genistein, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Genistein and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Peritoneal Mesothelioma due to abnormalities in genes BAP1 and PPM1D – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PERITONEAL MESOTHELIOMA DUE TO GENES BAP1 AND PPM1D
Eat more vegetables, Cassava or Chicory?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.
For genetic risk of Peritoneal Mesothelioma due to abnormalities in genes BAP1 and PPM1D – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF PERITONEAL MESOTHELIOMA DUE TO GENES BAP1 AND PPM1D
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Raspberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Resveratrol, Vitamin C, Quercetin, Ellagic Acid, Salicylic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Peritoneal Mesothelioma due to abnormalities in genes BAP1 and PPM1D – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF PERITONEAL MESOTHELIOMA DUE TO GENES BAP1 AND PPM1D
Eat more nuts, Pecan Nut or Chestnut?
The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Quercetin, Oleic Acid, Ellagic Acid, Linolenic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
For genetic risk of Peritoneal Mesothelioma due to abnormalities in genes BAP1 and PPM1D – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF PERITONEAL MESOTHELIOMA DUE TO GENES BAP1 AND PPM1D
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Peritoneal Mesothelioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.