Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Papillary Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Papillary Renal Cell Carcinoma because of BIRC6 and PLEC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Papillary Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Neem Extract and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PAPILLARY RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Papillary Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PAPILLARY RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Papillary Renal Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Papillary Renal Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Papillary Renal Cell Carcinoma are in ages between 3 to 88 with an average age of 60. 73.0% of males and 27.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 938; the top genes with mutations and other abnormalities for Papillary Renal Cell Carcinoma include genes BIRC6, PLEC, DYNC1H1, FASN and CENPE. The occurrence frequency distribution for these genes respectively is 2.7%, 2.1%, 2.1%, 1.8% and 1.8%. These tumor genetic details of Papillary Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Papillary Renal Cell Carcinoma.
Significance of Nutrition for Papillary Renal Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Papillary Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Chlorogenic Acid, Beta-sitosterol, Naringin, Linolenic Acid, Hesperetin and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Papillary Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Small Molecule Transport, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Papillary Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PAPILLARY RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Papillary Renal Cell Carcinoma undergoing chemotherapy treatment
In Papillary Renal Cell Carcinoma – the genes BIRC6, PLEC, DYNC1H1, FASN and CENPE have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Papillary Renal Cell Carcinoma are Post Translation Modification, RAS-RAF Signaling, mRNA Splicing and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Post Translation Modification, RAS-RAF Signaling, mRNA Splicing so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Genistein, Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Isoliquiritigenin has biological action on biochemical pathways Microtubule Dynamics, TGFB Signaling and JAK-STAT Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin C has biological action on biochemical pathways Heat Stress Response. And so on.
When treating Papillary Renal Cell Carcinoma with chemotherapy Radiation – Foods like Adzuki Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin C in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER PIGEON PEA FOR PAPILLARY RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Okra?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Okra are Quercetin, Beta-sitosterol, Linolenic Acid, Salicylic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin A has biological action on biochemical pathways Stem Cell Signaling, Oxidative Stress and TGFB Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Salicylic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Oxidative Stress. And so on.
When treating Papillary Renal Cell Carcinoma with chemotherapy Radiation – Foods like Cassava are recommended compared to Okra. This is because the active ingredients Quercetin and Salicylic Acid in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin A contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER OKRA FOR PAPILLARY RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pummelo are Chlorogenic Acid, Beta-sitosterol, Naringin, Linolenic Acid, Hesperetin and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Oxidative Stress.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Heat Stress Response, DNA Repair and Oxidative Stress. And so on.
When treating Papillary Renal Cell Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PUMMELO FOR PAPILLARY RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Gamma-linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Papillary Renal Cell Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Citric Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR PAPILLARY RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Papillary Renal Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BIRC6 and PLEC are two genes whose abnormalities are risk factors for Papillary Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Papillary Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Papillary Renal Cell Carcinoma gene BIRC6 has causative impact on biological pathways like . And PLEC has a causative impact on biological pathways like Extracellular Matrix Remodelling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BIRC6 and PLEC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BIRC6 and PLEC should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Vitexin, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Soy Bean are Daidzein, Lupeol, Quercetin, Vitamin E, Vitamin C and others.
Vitexin can manipulate biochemical pathways Small Molecule Transport, MYC Signaling and Calcium Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Papillary Renal Cell Carcinoma due to abnormalities in genes BIRC6 and PLEC – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitexin and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PAPILLARY RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND PLEC
Eat more vegetables, Arrowroot or Radish?
The active ingredients contained in Arrowroot are Protocatechuic Acid, Quercetin, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Protocatechuic Acid can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. Beta-carotene has biological action on biochemical pathways Calcium Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport and Calcium Signaling. And so on.
For genetic risk of Papillary Renal Cell Carcinoma due to abnormalities in genes BIRC6 and PLEC – Foods like Arrowroot are recommended compared to Radish. This is because the active ingredients Pelargonidin and Isorhamnetin in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Protocatechuic Acid and Beta-carotene contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF PAPILLARY RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND PLEC
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Bilberry or Elderberry?
The active ingredients contained in Bilberry are Resveratrol, Quercetin, P-coumaric Acid, Arbutin, Chlorogenic Acid among others. While the active ingredients contained in Elderberry are Lupeol, Quercetin, Betulinic Acid, Vitamin C, Oleic Acid and others.
Arbutin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Chlorogenic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling and MYC Signaling.
Rutin can manipulate biochemical pathways Extracellular Matrix Remodelling. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport and Calcium Signaling. And so on.
For genetic risk of Papillary Renal Cell Carcinoma due to abnormalities in genes BIRC6 and PLEC – Foods like Bilberry are recommended compared to Elderberry. This is because the active ingredients Rutin and Isorhamnetin in Elderberry further promote the effects of genes on the biochemical pathways. While the active ingredients Arbutin and Chlorogenic Acid contained in Bilberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER ELDERBERRY FOR REDUCING THE GENETIC RISK OF PAPILLARY RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND PLEC
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Beta-carotene, Quercitrin and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, Calcium Signaling and Cell Cycle Checkpoints. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Papillary Renal Cell Carcinoma due to abnormalities in genes BIRC6 and PLEC – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF PAPILLARY RENAL CELL CARCINOMA DUE TO GENES BIRC6 AND PLEC
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Papillary Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Ch 2020
- Pan-cancer analysis of whole genomes.
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- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
- The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Small-molecule inhibitors of NADPH oxidase 4.
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
- Research progress on the anticancer effects of vitamin K2.
- Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Osteopetrotic (grey-lethal) bone produces collagenase and TIMP in organ culture: regulation by vitamin A.
- Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
- Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
- Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.
- Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
- Binding studies and biological evaluation of β-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.