Which Foods are Recommended for Thymic Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Thymic Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Thymic Carcinoma because of CYLD and CDKN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Thymic Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Guggul and Chaga Mushroom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THYMIC CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Thymic Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR THYMIC CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Thymic Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Thymic Carcinoma from cBioPortal. The patients enrolled in the studies for Thymic Carcinoma are in ages between 16 to 83 with an average age of 60. 50.6% of males and 49.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 78; the top genes with mutations and other abnormalities for Thymic Carcinoma include genes CDKN2A, CYLD, KMT2D, TP53 and KMT2C. The occurrence frequency distribution for these genes respectively is 9.1%, 9.1%, 6.1%, 6.1% and 6.1%. These tumor genetic details of Thymic Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Thymic Carcinoma.

Significance of Nutrition for Thymic Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Thymic Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Quercetin, Resveratrol, Ellagic Acid, Hyperoside, Vitamin C and others. And Pomegranate contains active ingredients Apigenin, Betulinic Acid, Beta-sitosterol, Maslinic Acid, Ellagic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Thymic Carcinoma, activation or inhibition of selected biochemical pathways like Nutrient sensing, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Thymic Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THYMIC CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Thymic Carcinoma undergoing chemotherapy treatment

In Thymic Carcinoma – the genes CDKN2A, CYLD, KMT2D, TP53 and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Thymic Carcinoma are Nutrient sensing, Cell Cycle Checkpoints, Apoptosis and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Nutrient sensing, Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.

Apigenin can manipulate biochemical pathways DNA Repair and Nutrient sensing. Esculin has biological action on biochemical pathways DNA Repair. And so on.

When treating Thymic Carcinoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR THYMIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Vitamin C, Linolenic Acid, Brassinin, Oleic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and P53 Signaling.

Trans-trans-farnesol can manipulate biochemical pathways Nutrient sensing. Linoleic Acid has biological action on biochemical pathways Nutrient sensing. And so on.

When treating Thymic Carcinoma with chemotherapy Doxorubicin – Foods like Kohlrabi are recommended compared to Beetroot. This is because the active ingredients Trans-trans-farnesol and Linoleic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER BEETROOT FOR THYMIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more fruits, Pomegranate or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Betulinic Acid, Beta-sitosterol, Maslinic Acid, Ellagic Acid among others. While the active ingredients contained in Cranberry are Quercetin, Resveratrol, Ellagic Acid, Hyperoside, Vitamin C and others.

Betulinic Acid can manipulate biochemical pathways Hedgehog Signaling, Apoptosis and NFKB Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, MYC Signaling and Cell Cycle Checkpoints.

Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

When treating Thymic Carcinoma with chemotherapy Doxorubicin – Foods like Pomegranate are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER CRANBERRY FOR THYMIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Quercetin, Rhamnetin, Vitamin C and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Quercetin has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Vitamin B3 has biological action on biochemical pathways Nutrient sensing. And so on.

When treating Thymic Carcinoma with chemotherapy Doxorubicin – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR THYMIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Thymic Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CYLD and CDKN2A are two genes whose abnormalities are risk factors for Thymic Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Thymic Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Thymic Carcinoma gene CYLD has causative impact on biological pathways like Interferon Signaling, C-type Lectin Receptor Signaling and Apoptosis. And CDKN2A has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CYLD and CDKN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CYLD and CDKN2A should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Quercetin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Thymic Carcinoma due to abnormalities in genes CYLD and CDKN2A – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF THYMIC CARCINOMA DUE TO GENES CYLD AND CDKN2A

Eat more vegetables, Jicama or Celery?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Cynaroside has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Thymic Carcinoma due to abnormalities in genes CYLD and CDKN2A – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF THYMIC CARCINOMA DUE TO GENES CYLD AND CDKN2A

Eat more fruits, Feijoa or Orange?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in orange are D-Limonene, Vitamin C, Linoleic Acid, Pelargonidin, Hesperidin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Linoleic Acid can manipulate biochemical pathways Angiogenesis. Pelargonidin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and Angiogenesis. And so on.

For genetic risk of Thymic Carcinoma due to abnormalities in genes CYLD and CDKN2A – Foods like Feijoa are recommended compared to Orange. This is because the active ingredients Linoleic Acid and Pelargonidin in orange further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER ORANGE FOR REDUCING THE GENETIC RISK OF THYMIC CARCINOMA DUE TO GENES CYLD AND CDKN2A

Eat more nuts, Pecan Nut or Chestnut?

The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Thymic Carcinoma due to abnormalities in genes CYLD and CDKN2A – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF THYMIC CARCINOMA DUE TO GENES CYLD AND CDKN2A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Thymic Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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