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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Intraductal Papillary Mucinous Neoplasm?

Jul 31, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Intraductal Papillary Mucinous Neoplasm when undergoing chemotherapy or when you determine you have a genetic risk for developing Intraductal Papillary Mucinous Neoplasm because of CHEK2 and PPM1D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Intraductal Papillary Mucinous Neoplasm which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Intraductal Papillary Mucinous Neoplasm is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Intraductal Papillary Mucinous Neoplasm

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Intraductal Papillary Mucinous Neoplasm from cBioPortal. The patients enrolled in the studies for Intraductal Papillary Mucinous Neoplasm are in ages between 5 to 95 with an average age of 65. 52.7% of males and 47.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 1440; the top genes with mutations and other abnormalities for Intraductal Papillary Mucinous Neoplasm include genes DNMT3A, TET2, PPM1D, ASXL1 and CHEK2. The occurrence frequency distribution for these genes respectively is 33.4%, 11.3%, 8.8%, 4.5% and 3.4%. These tumor genetic details of Intraductal Papillary Mucinous Neoplasm are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Intraductal Papillary Mucinous Neoplasm.

Significance of Nutrition for Intraductal Papillary Mucinous Neoplasm

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Intraductal Papillary Mucinous Neoplasm. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Apigenin, Lupeol, Protocatechuic Acid, Beta-sitosterol and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Intraductal Papillary Mucinous Neoplasm, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Intraductal Papillary Mucinous Neoplasm, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Intraductal Papillary Mucinous Neoplasm, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Intraductal Papillary Mucinous Neoplasm undergoing chemotherapy treatment

In Intraductal Papillary Mucinous Neoplasm – the genes DNMT3A, TET2, PPM1D, ASXL1 and CHEK2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Intraductal Papillary Mucinous Neoplasm are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Kaempferol, Oleic Acid, Gamma-linolenic Acid, Delphinidin and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. Kaempferol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling and Focal Adhesion. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Oxidative Stress. And so on.

When treating Intraductal Papillary Mucinous Neoplasm with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Oxidative Stress and DNA Repair.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Focal Adhesion and Oncogenic Cancer Epigenetics. And so on.

When treating Intraductal Papillary Mucinous Neoplasm with chemotherapy Radiation – Foods like Cassava are recommended compared to Swede. This is because the active ingredients Lycopene and Oleic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SWEDE FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Science of Right Personalized Nutrition for Cancer

Eat more fruits, Partridgeberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Date are Quercetin, Apigenin, Lupeol, Protocatechuic Acid, Beta-sitosterol and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Oxidative Stress and DNA Repair.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Oxidative Stress. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intraductal Papillary Mucinous Neoplasm with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Date. This is because the active ingredients Apigenin and Protocatechuic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER DATE FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Oxidative Stress. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.

When treating Intraductal Papillary Mucinous Neoplasm with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Intraductal Papillary Mucinous Neoplasm

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CHEK2 and PPM1D are two genes whose abnormalities are risk factors for Intraductal Papillary Mucinous Neoplasm. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Intraductal Papillary Mucinous Neoplasm can be used as a guide for coming up with a recommended personalized nutrition plan. For Intraductal Papillary Mucinous Neoplasm gene CHEK2 has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And PPM1D has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CHEK2 and PPM1D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CHEK2 and PPM1D should be avoided.

Eat more pulses, Scarlet Bean or Hyacinth Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Linolenic Acid, Beta-sitosterol, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid, Myristic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Intraductal Papillary Mucinous Neoplasm due to abnormalities in genes CHEK2 and PPM1D – Foods like Scarlet Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM DUE TO GENES CHEK2 AND PPM1D

Eat more vegetables, Jicama or Celery?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Linolenic Acid, Quercetin, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Apoptosis.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics and MAPK Signaling. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Intraductal Papillary Mucinous Neoplasm due to abnormalities in genes CHEK2 and PPM1D – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM DUE TO GENES CHEK2 AND PPM1D

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Hyperoside, Vitamin C, Resveratrol, P-coumaric Acid, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Casuarinin has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Intraductal Papillary Mucinous Neoplasm due to abnormalities in genes CHEK2 and PPM1D – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM DUE TO GENES CHEK2 AND PPM1D

Eat more nuts, Pecan Nut or Chestnut?

The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.

For genetic risk of Intraductal Papillary Mucinous Neoplasm due to abnormalities in genes CHEK2 and PPM1D – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM DUE TO GENES CHEK2 AND PPM1D


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Intraductal Papillary Mucinous Neoplasm by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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