Which Foods are Recommended for Male Breast Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Male Breast Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Male Breast Cancer because of GATA3 and SPEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Male Breast Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Currant in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Alpha Lipoic Acid and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MALE BREAST CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Male Breast Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MALE BREAST CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Male Breast Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Male Breast Cancer from cBioPortal. The top genes with mutations and other abnormalities for Male Breast Cancer include genes PIK3CA, GATA3, SPEN, MAP3K1 and TP53. The occurrence frequency distribution for these genes respectively is 20.3%, 15.3%, 10.2%, 8.5% and 8.5%. These tumor genetic details of Male Breast Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Male Breast Cancer.

Significance of Nutrition for Male Breast Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Male Breast Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Gooseberry includes active ingredients Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Gallic Acid and others. And Currant contains active ingredients Delphinidin, Quercetin, Cianidanol, Gamma-linolenic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Male Breast Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Apoptosis, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Male Breast Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MALE BREAST CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Male Breast Cancer undergoing chemotherapy treatment

In Male Breast Cancer – the genes PIK3CA, GATA3, SPEN, MAP3K1 and TP53 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Male Breast Cancer are RAS-RAF Signaling, Apoptosis, Growth Factor Signaling and others. Lapatinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Apoptosis, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Genistein among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Male Breast Cancer with chemotherapy Lapatinib – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR MALE BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY LAPATINIB FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin B3, Vitamin A among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Male Breast Cancer with chemotherapy Lapatinib – Foods like Giant Butterbur are recommended compared to Endive. This is because the active ingredients Vitamin A and Oleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER ENDIVE FOR MALE BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY LAPATINIB FOR SOME CONDITIONS.

Eat more fruits, Currant or Gooseberry?

Fruits are an important part of many diets. The active ingredients contained in Currant are Delphinidin, Quercetin, Cianidanol, Gamma-linolenic Acid, Vitamin C among others. While the active ingredients contained in Gooseberry are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Gallic Acid and others.

Delphinidin can manipulate biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and MYC Signaling. Cianidanol has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Male Breast Cancer with chemotherapy Lapatinib – Foods like Currant are recommended compared to Gooseberry. This is because the active ingredients Rutin and Oleic Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Cianidanol contained in Currant support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER GOOSEBERRY FOR MALE BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY LAPATINIB FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Delphinidin, Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.

Delphinidin can manipulate biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and P53 Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Quercitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Male Breast Cancer with chemotherapy Lapatinib – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Quercitrin in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Vitamin E contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR MALE BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY LAPATINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Male Breast Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GATA3 and SPEN are two genes whose abnormalities are risk factors for Male Breast Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Male Breast Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Male Breast Cancer gene GATA3 has causative impact on biological pathways like IL27 Signaling and Cytokine Signaling. And SPEN has a causative impact on biological pathways like Notch Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GATA3 and SPEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GATA3 and SPEN should be avoided.

Eat more pulses, Common Pea or Common Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Linolenic Acid, Ferulic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Male Breast Cancer due to abnormalities in genes GATA3 and SPEN – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF MALE BREAST CANCER DUE TO GENES GATA3 AND SPEN

Eat more vegetables, Arugula or Bell Pepper?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Linolenic Acid, Vitamin C, Capsaicin, P-coumaric Acid and others.

Kaempferol can manipulate biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints.

Capsaicin can manipulate biochemical pathways NFKB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Male Breast Cancer due to abnormalities in genes GATA3 and SPEN – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF MALE BREAST CANCER DUE TO GENES GATA3 AND SPEN

Eat more fruits, Cherimoya or Raspberry?

The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Raspberry are Resveratrol, Salicylic Acid, Vitamin C, Ellagic Acid, Quercetin and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Male Breast Cancer due to abnormalities in genes GATA3 and SPEN – Foods like Cherimoya are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF MALE BREAST CANCER DUE TO GENES GATA3 AND SPEN

Eat more nuts, Almond or Chestnut?

The active ingredients contained in Almond are Beta-sitosterol, Vitamin E, Salicylic Acid, Linolenic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Linolenic Acid, Vitamin C, Ellagic Acid, Oleic Acid, Quercetin and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Male Breast Cancer due to abnormalities in genes GATA3 and SPEN – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF MALE BREAST CANCER DUE TO GENES GATA3 AND SPEN

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Male Breast Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
• Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
• Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Research progress on the anticancer effects of vitamin K2.
• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.