Which Foods are Recommended for Endometrioid Ovarian Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Endometrioid Ovarian Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Endometrioid Ovarian Cancer because of ARID1A and CHD4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Endometrioid Ovarian Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Curcumin and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ENDOMETRIOID OVARIAN CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Endometrioid Ovarian Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ENDOMETRIOID OVARIAN CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Endometrioid Ovarian Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Endometrioid Ovarian Cancer from cBioPortal. From a patient sample size of 12; the top genes with mutations and other abnormalities for Endometrioid Ovarian Cancer include genes ARID1A, TP53, CHD4, FAT3 and RUNX1. The occurrence frequency distribution for these genes respectively is 37.5%, 37.5%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Endometrioid Ovarian Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Endometrioid Ovarian Cancer.

Significance of Nutrition for Endometrioid Ovarian Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Endometrioid Ovarian Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Lupeol, Protocatechuic Acid, Beta-sitosterol, Apigenin and others. And Apple contains active ingredients Modified Citrus Pectin, Phloretin, Glucaric Acid, Cianidanol, Caffeic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Endometrioid Ovarian Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Endometrioid Ovarian Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ENDOMETRIOID OVARIAN CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Endometrioid Ovarian Cancer undergoing chemotherapy treatment

In Endometrioid Ovarian Cancer – the genes ARID1A, TP53, CHD4, FAT3 and RUNX1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Endometrioid Ovarian Cancer are RAS-RAF Signaling, MAPK Signaling, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, MAPK Signaling, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Yellow Wax Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Butyric Acid, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A, Genistein and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and RAS-RAF Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Endometrioid Ovarian Cancer with chemotherapy Radiation – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Palmitic Acid contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR ENDOMETRIOID OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Bell Pepper?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Isorhamnetin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling.

Capsaicin can manipulate biochemical pathways DNA Repair and MAPK Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Endometrioid Ovarian Cancer with chemotherapy Radiation – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Oleic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR ENDOMETRIOID OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Apple or Date?

Fruits are an important part of many diets. The active ingredients contained in Apple are Modified Citrus Pectin, Phloretin, Glucaric Acid, Cianidanol, Caffeic Acid among others. While the active ingredients contained in Date are Quercetin, Lupeol, Protocatechuic Acid, Beta-sitosterol, Apigenin and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Modified Citrus Pectin has biological action on biochemical pathways JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition and DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Endometrioid Ovarian Cancer with chemotherapy Radiation – Foods like Apple are recommended compared to Date. This is because the active ingredients Apigenin and Oleic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: APPLE IS RECOMMENDED OVER DATE FOR ENDOMETRIOID OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and MYC Signaling. Cianidanol has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Endometrioid Ovarian Cancer with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER MACADAMIA NUT FOR ENDOMETRIOID OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Endometrioid Ovarian Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID1A and CHD4 are two genes whose abnormalities are risk factors for Endometrioid Ovarian Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Endometrioid Ovarian Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Endometrioid Ovarian Cancer gene ARID1A has causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. And CHD4 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling and Inositol Phosphate Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID1A and CHD4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID1A and CHD4 should be avoided.

Eat more pulses, Common Pea or Common Bean?

The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, P-coumaric Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Adherens junction and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Pelargonidin can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Endometrioid Ovarian Cancer due to abnormalities in genes ARID1A and CHD4 – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF ENDOMETRIOID OVARIAN CANCER DUE TO GENES ARID1A AND CHD4

Eat more vegetables, Mexican Groundcherry or Chicory?

The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Adherens junction and WNT Beta Catenin Signaling. Vitamin B3 has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Luteolin can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Endometrioid Ovarian Cancer due to abnormalities in genes ARID1A and CHD4 – Foods like Mexican Groundcherry are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF ENDOMETRIOID OVARIAN CANCER DUE TO GENES ARID1A AND CHD4

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Cranberry are Vitamin C, Resveratrol, P-coumaric Acid, Hyperoside, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Adherens junction and WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

For genetic risk of Endometrioid Ovarian Cancer due to abnormalities in genes ARID1A and CHD4 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ENDOMETRIOID OVARIAN CANCER DUE TO GENES ARID1A AND CHD4

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Oleic Acid, Quercetin, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Endometrioid Ovarian Cancer due to abnormalities in genes ARID1A and CHD4 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ENDOMETRIOID OVARIAN CANCER DUE TO GENES ARID1A AND CHD4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Endometrioid Ovarian Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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