Which Foods are Recommended for Desmoplastic Melanoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Desmoplastic Melanoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Desmoplastic Melanoma because of DCC and FAT4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Desmoplastic Melanoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Alpha Lipoic Acid and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DESMOPLASTIC MELANOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Desmoplastic Melanoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR DESMOPLASTIC MELANOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Desmoplastic Melanoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Desmoplastic Melanoma from cBioPortal. The patients enrolled in the studies for Desmoplastic Melanoma are in ages between 30 to 85 with an average age of 71.From a patient sample size of 24; the top genes with mutations and other abnormalities for Desmoplastic Melanoma include genes DCC, FAT4, COL4A4, LRP2 and SLIT2. The occurrence frequency distribution for these genes respectively is 56.5%, 43.5%, 43.5%, 39.1% and 39.1%. These tumor genetic details of Desmoplastic Melanoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Desmoplastic Melanoma.

Significance of Nutrition for Desmoplastic Melanoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Desmoplastic Melanoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Lupeol, Beta-sitosterol, Protocatechuic Acid, Linolenic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Desmoplastic Melanoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Extracellular Matrix Remodelling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Desmoplastic Melanoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DESMOPLASTIC MELANOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Desmoplastic Melanoma undergoing chemotherapy treatment

In Desmoplastic Melanoma – the genes DCC, FAT4, COL4A4, LRP2 and SLIT2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Desmoplastic Melanoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Delphinidin, Kaempferol, Genistein among others. While the active ingredients contained in Pigeon Pea are Genistein, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways TGFB Signaling, Extracellular Matrix Remodelling and Notch Signaling. And so on.

When treating Desmoplastic Melanoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR DESMOPLASTIC MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Stem Cell Signaling and Microtubule Dynamics.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Desmoplastic Melanoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Swede. This is because the active ingredients Lycopene and Linolenic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER SWEDE FOR DESMOPLASTIC MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Rowanberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Date are Quercetin, Lupeol, Beta-sitosterol, Protocatechuic Acid, Linolenic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Quercetin has biological action on biochemical pathways Microtubule Dynamics, DNA Repair and Growth Factor Signaling.

Lupeol can manipulate biochemical pathways Cytoskeletal Dynamics. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Desmoplastic Melanoma with chemotherapy Radiation – Foods like Rowanberry are recommended compared to Date. This is because the active ingredients Lupeol and Protocatechuic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER DATE FOR DESMOPLASTIC MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Cucurbitacin I, Linolenic Acid, Gamma-linolenic Acid, Salicylic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, Cytoskeletal Dynamics and JAK-STAT Signaling. And so on.

When treating Desmoplastic Melanoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR DESMOPLASTIC MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Desmoplastic Melanoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DCC and FAT4 are two genes whose abnormalities are risk factors for Desmoplastic Melanoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Desmoplastic Melanoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Desmoplastic Melanoma gene DCC has causative impact on biological pathways like Apoptosis and Netrin Signaling. And FAT4 has a causative impact on biological pathways like Cytoskeletal Dynamics and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DCC and FAT4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DCC and FAT4 should be avoided.

Eat more pulses, Hyacinth Bean or Moth Bean?

The active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Linoleic Acid, Oleic Acid and others.

Palmitic Acid can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Netrin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Desmoplastic Melanoma due to abnormalities in genes DCC and FAT4 – Foods like Hyacinth Bean are recommended compared to Moth Bean. This is because the active ingredients Oleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC MELANOMA DUE TO GENES DCC AND FAT4

Eat more vegetables, Carrot or Bell Pepper?

The active ingredients contained in Carrot are D-limonene, Lupeol, Vitamin E, Quercetin, Osthole among others. While the active ingredients contained in Bell Pepper are Vitamin E, Capsaicin, Linolenic Acid, Vitamin C, P-coumaric Acid and others.

Osthole can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-cryptoxanthin has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Capsaicin can manipulate biochemical pathways Small Molecule Transport. Dihydrocapsaicin has biological action on biochemical pathways Small Molecule Transport. And so on.

For genetic risk of Desmoplastic Melanoma due to abnormalities in genes DCC and FAT4 – Foods like Carrot are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Dihydrocapsaicin in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Osthole and Beta-cryptoxanthin contained in Carrot together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CARROT IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC MELANOMA DUE TO GENES DCC AND FAT4

Eat more fruits, Grapefruit or Raspberry?

The active ingredients contained in Grapefruit are Naringin, Linolenic Acid, Linoleic Acid, Oleic Acid, Naringenin among others. While the active ingredients contained in Raspberry are Quercetin, Vitamin C, Ellagic Acid, Resveratrol, Gallic Acid and others.

Naringin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Naringenin has biological action on biochemical pathways Cell Cycle Checkpoints, Extracellular Matrix Remodelling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Desmoplastic Melanoma due to abnormalities in genes DCC and FAT4 – Foods like Grapefruit are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Naringin and Naringenin contained in Grapefruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPEFRUIT IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC MELANOMA DUE TO GENES DCC AND FAT4

Eat more nuts, Pistachio or Macadamia Nut?

The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Desmoplastic Melanoma due to abnormalities in genes DCC and FAT4 – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC MELANOMA DUE TO GENES DCC AND FAT4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Desmoplastic Melanoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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