Foods for Breast Invasive Ductal Carcinoma!

Introduction

Foods for Breast Invasive Ductal Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Breast invasive ductal carcinoma is the most common type of breast cancer, characterized by the abnormal growth of cells in the milk ducts that invade the surrounding breast tissue. Accurate medical coding using the appropriate ICD-10 code is crucial for documentation. Pathology outlines provide valuable information about the characteristics of invasive ductal carcinoma. Treatment options for invasive ductal carcinoma of the breast may include surgery, chemotherapy, radiation therapy, and targeted therapies tailored to individual cases. Understanding the grade and stage of the cancer is important for prognosis and treatment decisions. Monitoring survival statistics and prognosis helps patients and their families gain a better understanding of the potential outcome. Comprehensive treatment approaches, including chemotherapy, can target invasive ductal carcinoma of the breast, while immunohistochemistry helps identify the specific biomarkers present. By staying informed and exploring all available treatment options, individuals diagnosed with invasive ductal carcinoma can improve their chances of a successful outcome. Regular screening and recognizing symptoms play a significant role in early detection and timely treatment of invasive ductal carcinoma of the breast.

For Breast Invasive Ductal Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Breast Invasive Ductal Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Breast Invasive Ductal Carcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Leek? Does it make any difference if fruit Pear is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Chia over European Chestnut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Breast Invasive Ductal Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Breast Invasive Ductal Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pear contains active ingredients Curcumin, Lupeol, Formononetin, Beta-sitosterol, Daidzein. And Pomegranate contains active ingredients Curcumin, Apigenin, Quercetin, Lupeol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Breast Invasive Ductal Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Breast Invasive Ductal Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Breast Invasive Ductal Carcinoma?

Personalized nutrition for cancers like Breast Invasive Ductal Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Breast Invasive Ductal Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Breast Invasive Ductal Carcinoma

All cancers like Breast Invasive Ductal Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathway. Biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, MAPK Signaling, PI3K-AKT-MTOR Signaling are part of the signature definition of Breast Invasive Ductal Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Breast Invasive Ductal Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Breast Invasive Ductal Carcinoma when taking cancer treatment Letrozole, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, GATA3, TET1, MAP3K1 and MUC16 are the top ranked reported genes for Breast Invasive Ductal Carcinoma. TP53 is reported in 1.9 % of the representative patients across all clinical trials. And GATA3 is reported in 0.4 %. The combined population patient data cover ages from 23 to 90. 0.8 % of the patient data are identified as men. The Breast Invasive Ductal Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Breast Invasive Ductal Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or LEEK?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Metastasis, NFKB Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. New Zealand Spinach is recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Letrozole.

Some of the active ingredients or bioactives in vegetable Leek are Curcumin, Apigenin, Lupeol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Leek is not recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER LEEK FOR Breast Invasive Ductal Carcinoma AND TREATMENT Letrozole.

Choose Fruit POMEGRANATE or PEAR?

Fruit Pomegranate contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Metastasis, NFKB Signaling, JAK-STAT Signaling and Cell Cycle and others. Pomegranate is recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Letrozole.

Some of the active ingredients or bioactives in fruit Pear are Curcumin, Lupeol, Formononetin, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Pear is not recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PEAR FOR Breast Invasive Ductal Carcinoma AND TREATMENT Letrozole.

Choose Nut CHIA or EUROPEAN CHESTNUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Metastasis, NFKB Signaling, Cell Cycle and JAK-STAT Signaling and others. Chia is recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Letrozole.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Breast Invasive Ductal Carcinoma when ongoing cancer treatment is Letrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Breast Invasive Ductal Carcinoma AND TREATMENT Letrozole.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Breast Invasive Ductal Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHINESE BROCCOLI?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling and DNA Repair and others. Giant Butterbur is recommended for risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Chinese Broccoli is not recommended when risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE BROCCOLI FOR GATA3 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling and DNA Repair and others. Nance is recommended for risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Daidzein, Lupeol, Quercetin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and DNA Repair and others. Pummelo is not recommended when risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR GATA3 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Daidzein, Lupeol, Quercetin, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling and Growth Factor Signaling and others. Common Hazelnut is recommended for risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling and DNA Repair and others. Flaxseed is not recommended when risk of Breast Invasive Ductal Carcinoma when associated genetic risk is GATA3 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR GATA3 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Breast Invasive Ductal Carcinoma. Breast Invasive Ductal Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Breast Invasive Ductal Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Breast Invasive Ductal Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy.
• New concepts in phospholipase D signaling in inflammation and cancer.