Which Foods are Recommended for Myxoid Liposarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Myxoid Liposarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Myxoid Liposarcoma because of KMT2A and PTEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Myxoid Liposarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Cordyceps and Curcumin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MYXOID LIPOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Myxoid Liposarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MYXOID LIPOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Myxoid Liposarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Myxoid Liposarcoma from cBioPortal. 59.1% of males and 40.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 66; the top genes with mutations and other abnormalities for Myxoid Liposarcoma include genes TERT, PIK3CA, PTEN, TP53 and KMT2A. The occurrence frequency distribution for these genes respectively is 65.7%, 31.4%, 17.1%, 8.6% and 2.9%. These tumor genetic details of Myxoid Liposarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Myxoid Liposarcoma.

Myxoid liposarcoma is one of the several types of liposarcomas, a rare cancer that develops in the fat cells of the body. Myxoid liposarcoma usually grows in the arms and legs. These tumors are slow-growing, and they can spread to other parts of the body. Myxoid liposarcomas are more common in people aged 20 to 40 years old and rarely seen in children under 10 years of age. Initially this tumor is asymptomatic but as it grows larger, it can have symptoms such as a visible lump under the skin, pain, tenderness, nausea, and unintentional weight loss. The diagnosis of myxoid liposarcoma is typically made through cytology and imaging techniques like MRI. The treatment of myxoid liposarcoma may include surgery, radiation therapy, or chemotherapy, and the goal of treatment is to achieve complete removal of the tumor while preserving the function of surrounding tissues. The prognosis of myxoid liposarcoma is dependent on various factors like the location, size, and stage of the tumor. While the outlook for myxoid liposarcoma is generally good, patients are advised to consult an expert oncologist and undergo regular follow-up to monitor the progression of the disease. Additionally, supportive care with optimal nutrition (food and natural supplements) can help improve the patients’ well-being. (Ref: https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-soft-tissue-tumors/myxoid-round-cell-liposarcoma ; https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=99967; https://my.clevelandclinic.org/health/diseases/21142-liposarcoma)

Significance of Nutrition for Myxoid Liposarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Myxoid Liposarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Myxoid Liposarcoma, activation or inhibition of selected biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, Apoptosis, Inositol Phosphate Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Myxoid Liposarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MYXOID LIPOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Myxoid Liposarcoma undergoing chemotherapy treatment

In Myxoid Liposarcoma – the genes TERT, PIK3CA, PTEN, TP53 and KMT2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Myxoid Liposarcoma are DNA Repair, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Lentils?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Oleic Acid, Glucaric Acid, Vitamin C, Linolenic Acid, Vitexin among others. While the active ingredients contained in Lentils are Oleic Acid, Esculin, Daidzein, Beta-sitosterol, Vitamin C and others.

Glucaric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

When treating Myxoid Liposarcoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Folic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LENTILS FOR MYXOID LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Asparagus or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Oleic Acid, Isorhamnetin, Vitamin C, Linolenic Acid, Quercetin among others. While the active ingredients contained in Chicory are Apigenin, Lupeol, Esculin, Betulinic Acid, Caffeic Acid and others.

Isorhamnetin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

When treating Myxoid Liposarcoma with chemotherapy Radiation – Foods like Asparagus are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Isorhamnetin and Vitamin C contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER CHICORY FOR MYXOID LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Fig?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Fig are Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others.

Resveratrol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Myxoid Liposarcoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER FIG FOR MYXOID LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, DNA Repair and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Myxoid Liposarcoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR MYXOID LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Myxoid Liposarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KMT2A and PTEN are two genes whose abnormalities are risk factors for Myxoid Liposarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Myxoid Liposarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Myxoid Liposarcoma gene KMT2A has causative impact on biological pathways like Amino Acid Metabolism and Oncogenic Histone Methylation. And PTEN has a causative impact on biological pathways like Autophagy and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KMT2A and PTEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KMT2A and PTEN should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Beta-sitosterol, Vitamin E, Daidzein and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Myxoid Liposarcoma due to abnormalities in genes KMT2A and PTEN – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF MYXOID LIPOSARCOMA DUE TO GENES KMT2A AND PTEN

Eat more vegetables, Jicama or Radish?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Caffeic Acid, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Myxoid Liposarcoma due to abnormalities in genes KMT2A and PTEN – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF MYXOID LIPOSARCOMA DUE TO GENES KMT2A AND PTEN

Eat more fruits, Orange or Strawberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Hesperidin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Oleic Acid, Cianidanol and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.

For genetic risk of Myxoid Liposarcoma due to abnormalities in genes KMT2A and PTEN – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF MYXOID LIPOSARCOMA DUE TO GENES KMT2A AND PTEN

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Myxoid Liposarcoma due to abnormalities in genes KMT2A and PTEN – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MYXOID LIPOSARCOMA DUE TO GENES KMT2A AND PTEN

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Myxoid Liposarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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