Foods for Pheochromocytoma And Paraganglioma!

Introduction

Foods for Pheochromocytoma And Paraganglioma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Pheochromocytoma And Paraganglioma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Pheochromocytoma And Paraganglioma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Pheochromocytoma And Paraganglioma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Turnip? Does it make any difference if fruit Sweet Orange is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Butternut over Macadamia Nut and for pulses like Gram Bean over Mung Bean. And if what I eat matters – then how does one identify foods which are recommended for Pheochromocytoma And Paraganglioma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Pheochromocytoma And Paraganglioma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Sweet Orange contains active ingredients Luteolin, Phloretin, Bergapten, Cinnamaldehyde, Lupeol. And Rabbiteye Blueberry contains active ingredients Quercetin, Eugenol, Geraniol, Gallic Acid, Ferulic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Pheochromocytoma And Paraganglioma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Pheochromocytoma And Paraganglioma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Pheochromocytoma And Paraganglioma?

Personalized nutrition for cancers like Pheochromocytoma And Paraganglioma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Pheochromocytoma And Paraganglioma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Pheochromocytoma And Paraganglioma

All cancers like Pheochromocytoma And Paraganglioma can be characterized by a unique set of biochemical pathways – the signature pathways of Pheochromocytoma And Paraganglioma. Biochemical pathways like Vitamin Metabolism, Cell Cycle Checkpoints, Small Molecule Transport, Post Translation Modification are part of the signature definition of Pheochromocytoma And Paraganglioma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Pheochromocytoma And Paraganglioma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Pheochromocytoma And Paraganglioma when taking cancer treatment Cyclophosphamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

EPAS1, AWAT1, POLR1A, ATRX and ACER2 are the top ranked reported genes for Pheochromocytoma And Paraganglioma. EPAS1 is reported in 6.5 % of the representative patients across all clinical trials. And AWAT1 is reported in 3.2 %. The combined population patient data cover ages from 19 to 83. 45.0 % of the patient data are identified as men. The Pheochromocytoma And Paraganglioma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Pheochromocytoma And Paraganglioma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or TURNIP?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Luteolin, Myricetin, Phloretin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition, Vitamin Metabolism and MAPK Signaling and others. Giant Butterbur is recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in vegetable Turnip are Quercetin, Ellagic Acid, Phloretin, Cinnamaldehyde, Bergapten. These active ingredients manipulate various biochemical pathways like DNA Repair and Epithelial to Mesenchymal Transition and others. Turnip is not recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TURNIP FOR Pheochromocytoma And Paraganglioma AND TREATMENT Cyclophosphamide.

Choose Fruit RABBITEYE BLUEBERRY or SWEET ORANGE?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Eugenol, Geraniol, Gallic Acid, Ferulic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Cell Cycle Checkpoints and others. Rabbiteye Blueberry is recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in fruit Sweet Orange are Luteolin, Phloretin, Bergapten, Cinnamaldehyde, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle Checkpoints and others. Sweet Orange is not recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER SWEET ORANGE FOR Pheochromocytoma And Paraganglioma AND TREATMENT Cyclophosphamide.

Choose Nut BUTTERNUT or MACADAMIA NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Luteolin, Myricetin, Phloretin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like Cell Cycle, Vitamin Metabolism, DNA Repair and Epithelial to Mesenchymal Transition and others. Butternut is recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in Macadamia Nut are Apigenin, Luteolin, Myricetin, Phloretin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling and others. Macadamia Nut is not recommended for Pheochromocytoma And Paraganglioma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER MACADAMIA NUT FOR Pheochromocytoma And Paraganglioma AND TREATMENT Cyclophosphamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Pheochromocytoma And Paraganglioma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GARDEN CRESS or ROMAINE LETTUCE?

Vegetable Garden Cress contains many active ingredients or bioactives such as Curcumin, Lupeol, Beta-sitosterol, Formononetin, Vitamin C. These active ingredients manipulate various biochemical pathways like TGFB Signaling, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Garden Cress is recommended for risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2. This is because Garden Cress increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Romaine Lettuce are Curcumin, Apigenin, Lupeol, Resveratrol, Formononetin. These active ingredients manipulate various biochemical pathways like Lipid Metabolism and P53 Signaling and others. Romaine Lettuce is not recommended when risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2 because it increases the signature pathways of it.

VEGETABLE GARDEN CRESS IS RECOMMENDED OVER ROMAINE LETTUCE FOR ACER2 GENETIC RISK OF CANCER.

Choose Fruit BLACK CROWBERRY or GRAPEFRUIT?

Fruit Black Crowberry contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Hypoxia, P53 Signaling and Post Translation Modification and others. Black Crowberry is recommended for risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2. This is because Black Crowberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lupeol, Lycopene, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Lipid Metabolism and others. Grapefruit is not recommended when risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2 because it increases the signature pathways of it.

FRUIT BLACK CROWBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR ACER2 GENETIC RISK OF CANCER.

Choose Nut CHIA or HICKORY NUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Hypoxia, P53 Signaling and MYC Signaling and others. Chia is recommended for risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2. This is because Chia increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Lupeol, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Lipid Metabolism and Cell Cycle Checkpoints and others. Hickory Nut is not recommended when risk of Pheochromocytoma And Paraganglioma when associated genetic risk is ACER2 because it increases the signature pathways of it.

CHIA IS RECOMMENDED OVER HICKORY NUT FOR ACER2 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Pheochromocytoma And Paraganglioma. Pheochromocytoma And Paraganglioma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Pheochromocytoma And Paraganglioma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Pheochromocytoma And Paraganglioma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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