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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which 3 Foods to Avoid for Pheochromocytoma and Paraganglioma (PPGL)?

Aug 27, 2021

Estimated reading time: 7 minutes
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Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Pheochromocytoma and Paraganglioma (PPGL) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Cucumber and Tomato should be eaten when undergoing Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL). On the same lines, avoid foods like Spinach and Radish with treatment of Cyclophosphamide for Pheochromocytoma and Paraganglioma (PPGL). Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cyclophosphamide treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Pheochromocytoma and Paraganglioma (PPGL).



What is Pheochromocytoma and Paraganglioma (PPGL)?

Pheochromocytoma and Paraganglioma (PPGL) are rare neuroendocrine tumors that develop from the adrenal medulla (the center of the adrenal gland) and outside the adrenal gland respectively. The incidence rate of this cancer is only 0.66 per 1 lakh people per year. This cancer is commonly diagnosed in people who are between 30 and 50 years of age, however, it can occur in people of any age. It is diagnosed in men and women equally.

Symptoms, Treatment and Diet for Pheochromocytoma and Paraganglioma (PPGL)

Pheochromocytoma and Paraganglioma (PPGL) has prevalence of certain genetic changes. Some of the genes such as HRAS, NF1, TTN, and MAML3 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Pheochromocytoma and Paraganglioma (PPGL) can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Pheochromocytoma and Paraganglioma (PPGL). Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Pheochromocytoma and Paraganglioma (PPGL) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Pheochromocytoma and Paraganglioma (PPGL) nutrition may have to be redesigned.

Why Eating Right Matters for Pheochromocytoma and Paraganglioma (PPGL)?

In Pheochromocytoma and Paraganglioma (PPGL), activation or inhibition of some of the biochemical pathways including Adherens Junction, MAPK Signaling, MYC Signaling, Epithelial To Mesenchymal Transition, RAS-RAF Signaling, Oxidative Stress, Hypoxia, Cell Cycle, Apoptosis, PI3K-AKT-MTOR Signaling and Carbohydrate Metabolism plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Pheochromocytoma and Paraganglioma (PPGL), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL)

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Pheochromocytoma and Paraganglioma (PPGL) considering only one specific treatment- Cyclophosphamide.

Foods to eat and avoid for Pheochromocytoma and Paraganglioma (PPGL)

Foods to Avoid

Spinach : Spinach contains active ingredients such as Folic Acid, Linolenic Acid, Retinol and others. Folic Acid interferes with the impact of Cyclophosphamide in Pheochromocytoma and Paraganglioma (PPGL) by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Spinach with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL). 

Radish : Radish contains active ingredients such as Citric Acid, Linolenic Acid, Retinol and others. Citric Acid interferes with the impact of Cyclophosphamide in Pheochromocytoma and Paraganglioma (PPGL) by blocking a specific biological process called Oxidative Stress. Hence, avoid foods like Radish with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL). 

Foods to Eat

Cucumber :  Cucumber contains active ingredients like Beta-sitosterol, Fisetin and Linolenic Acid. Intake of Beta-sitosterol along with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL) causes a decrease in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cucumber hence should be eaten with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL). (Song Hyo Sook et al, Phytother Res., 2014; Juan Du et al, Int J Endocrinol., 2016)

Tomato :  Tomato contains active ingredients like Glucaric Acid, Rutin and Quercitrin. Intake of Glucaric Acid along with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL) causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Tomato hence should be eaten with Cyclophosphamide treatment for Pheochromocytoma and Paraganglioma (PPGL). (Prakash Tiwari et al, Biochimie., 2016; Juan Du et al, Int J Endocrinol., 2016)

Should I take this Nutritional Supplement for Pheochromocytoma and Paraganglioma (PPGL)?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cyclophosphamide treatment, and hence should not be used. Also, Black Seed supplement interferes with the impact of Cyclophosphamide in Pheochromocytoma and Paraganglioma (PPGL) by increasing pathways like Vitamin Metabolism.

Nutrition while on Chemotherapy | Personalized to Individual's Cancer type, Lifestyle & Genetics

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

What are the Symptoms of Pheochromocytoma and Paraganglioma (PPGL)?

In the initial stages, most cancers including Pheochromocytoma and Paraganglioma (PPGL) may not cause any signs or symptoms. However, as the disease progresses, Pheochromocytoma and Paraganglioma (PPGL) may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Pheochromocytoma and Paraganglioma (PPGL).

  • Fever
  • Headache
  • Nausea and vomiting
  • Breathlessness
  • Unexplained Weight loss
  • Chest or stomach pain
  • Extreme paleness in the face
  • Heavy sweating
  • Anxiety attacks
  • Irregular heartbeats
  • Tremors
  • Being extremely pale
  • Vision problems

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Pheochromocytoma and Paraganglioma (PPGL).

What are the Treatment Options for Pheochromocytoma and Paraganglioma (PPGL)?

The treatment for Pheochromocytoma and Paraganglioma (PPGL) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Pheochromocytoma and Paraganglioma (PPGL) include:

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Targeted therapy
  • Ablation therapy
  • Embolization therapy

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Pheochromocytoma and Paraganglioma (PPGL).

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Pheochromocytoma and Paraganglioma (PPGL).

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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