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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Diffuse Glioma?

Aug 26, 2021

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Diffuse Glioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Diffuse Glioma because of IDH1 and PTEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Diffuse Glioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Mango” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Ellagic Acid and Caffeine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DIFFUSE GLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Diffuse Glioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR DIFFUSE GLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Diffuse Glioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Diffuse Glioma from cBioPortal. The patients enrolled in the studies for Diffuse Glioma are in ages between 10 to 89 with an average age of 52. 59.0% of males and 41.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 1133; the top genes with mutations and other abnormalities for Diffuse Glioma include genes IDH1, TP53, ATRX, PTEN and EGFR. The occurrence frequency distribution for these genes respectively is 50.1%, 39.3%, 25.4%, 13.2% and 10.6%. These tumor genetic details of Diffuse Glioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Diffuse Glioma.

Significance of Nutrition for Diffuse Glioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Diffuse Glioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Mango includes active ingredients Beta-sitosterol, Lupeol, Oleic Acid, Linoleic Acid, Linolenic Acid and others. And Raspberry contains active ingredients Ellagic Acid, Resveratrol, Rutin, Salicylic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Diffuse Glioma, activation or inhibition of selected biochemical pathways like DNA Repair, Direct Repair, PI3K-AKT-MTOR Signaling, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Diffuse Glioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Diffuse Glioma, activation or inhibition of selected biochemical pathways like DNA Repair, Direct Repair, PI3K-AKT-MTOR Signaling, Hypoxia plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DIFFUSE GLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Diffuse Glioma undergoing chemotherapy treatment

In Diffuse Glioma – the genes IDH1, TP53, ATRX, PTEN and EGFR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Diffuse Glioma are DNA Repair, Direct Repair, MAPK Signaling and others. Procarbazine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Direct Repair, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Beta-sitosterol, Lupeol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Myristic Acid, Palmitic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, DNA Repair and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress, MAPK Signaling and Hypoxia.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Diffuse Glioma with chemotherapy Procarbazine – Foods like Common Pea are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Genistein in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER HYACINTH BEAN FOR DIFFUSE GLIOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Sulforaphane, Beta-sitosterol, Isorhamnetin, Glucaric Acid among others. While the active ingredients contained in Carob are Myricetin, Gallic Acid, Phloroglucinol, Quercetin, Palmitic Acid and others.

Glucaric Acid can manipulate biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress, Hypoxia and MAPK Signaling.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Myricetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Diffuse Glioma with chemotherapy Procarbazine – Foods like Cabbage are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CAROB FOR DIFFUSE GLIOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Which Foods are Recommended for Diffuse Glioma?

Eat more fruits, Raspberry or Mango?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Rutin, Salicylic Acid, Vitamin C among others. While the active ingredients contained in Mango are Beta-sitosterol, Lupeol, Oleic Acid, Linoleic Acid, Linolenic Acid and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, DNA Repair and MAPK Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress, PI3K-AKT-MTOR Signaling and Hypoxia.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Diffuse Glioma with chemotherapy Procarbazine – Foods like Raspberry are recommended compared to Mango. This is because the active ingredients Gallic Acid and Citric Acid in Mango interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER MANGO FOR DIFFUSE GLIOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linoleic Acid, Linolenic Acid, Myricitrin among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Gamma-linolenic Acid, Stigmasterol, Linoleic Acid and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and Notch Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Diffuse Glioma with chemotherapy Procarbazine – Foods like Hazelnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR DIFFUSE GLIOMA ON TREATMENT WITH CHEMOTHERAPY PROCARBAZINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Diffuse Glioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH1 and PTEN are two genes whose abnormalities are risk factors for Diffuse Glioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Diffuse Glioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Diffuse Glioma gene IDH1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And PTEN has a causative impact on biological pathways like Autophagy and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH1 and PTEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH1 and PTEN should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Diffuse Glioma due to abnormalities in genes IDH1 and PTEN – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF DIFFUSE GLIOMA DUE TO GENES IDH1 AND PTEN

Eat more vegetables, Jicama or Chicory?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Quercetin, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-carotene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Diffuse Glioma due to abnormalities in genes IDH1 and PTEN – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF DIFFUSE GLIOMA DUE TO GENES IDH1 AND PTEN

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Strawberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Strawberry are Lupeol, Beta-sitosterol, Vitamin C, Ellagic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and Apoptosis.

Fisetin can manipulate biochemical pathways MYC Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

For genetic risk of Diffuse Glioma due to abnormalities in genes IDH1 and PTEN – Foods like Feijoa are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF DIFFUSE GLIOMA DUE TO GENES IDH1 AND PTEN

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.

For genetic risk of Diffuse Glioma due to abnormalities in genes IDH1 and PTEN – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF DIFFUSE GLIOMA DUE TO GENES IDH1 AND PTEN


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Diffuse Glioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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