No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Small Cell Lung Cancer needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Beetroot and Bell Pepper should be eaten when undergoing Everolimus treatment for Small Cell Lung Cancer. On the same lines, avoid foods like Spinach and Radish with treatment of Everolimus for Small Cell Lung Cancer. Also, Black Seed supplement contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Everolimus treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Small Cell Lung Cancer.
What is Small Cell Lung Cancer (SCLC)?
Small Cell Lung Cancer is a fast growing cancer in which cancerous cells develop in the tissues of the lung. SCLC accounts for 13–15% of all new lung cancer cases in the United States. This cancer is commonly diagnosed in people who are about 60-80 years of age, however, it can occur in people of any age. It is more commonly found in White population as compared to Black population or Other ethnic groups.
Small Cell Lung Cancer has prevalence of certain genetic changes. Some of the genes such as TP53, RB1, TTN, and RYR2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Small Cell Lung Cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Small Cell Lung Cancer. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Small Cell Lung Cancer (SCLC) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Small Cell Lung Cancer (SCLC) nutrition may have to be redesigned.
Why Eating Right Matters for Small Cell Lung Cancer?
In Small Cell Lung Cancer, activation or inhibition of some of the biochemical pathways including Cell Cycle Checkpoints, WNT Beta Catenin Signaling, MAPK Signaling, Angiogenesis, Epithelial To Mesenchymal Transition, MYC Signaling, Extracellular Matrix Remodelling, Cancer Epigenetics, P53 Signaling, Vitamin D Signaling, Oxidative Stress, Hypoxia, Cell Cycle, Small Molecule Transport, Apoptosis, Nutrient Sensing, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Small Cell Lung Cancer, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Everolimus treatment for Small Cell Lung Cancer
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Small Cell Lung Cancer considering only one specific treatment- Everolimus.
Foods to Avoid with Everolimus treatment
Spinach : Spinach contains active ingredients such as Linoleic Acid, Linolenic Acid, Retinol and others. Linoleic Acid interferes with the impact of Everolimus in Small Cell Lung Cancer by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Spinach with Everolimus treatment for Small Cell Lung Cancer (SCLC).
Radish : Radish contains active ingredients such as Kaempferol, Linolenic Acid, Retinol and others. Kaempferol interferes with the impact of Everolimus in Small Cell Lung Cancer by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Radish with Everolimus treatment for Small Cell Lung Cancer (SCLC).
Foods to Eat with Everolimus treatment
Beetroot : Beetroot contains active ingredients like Beta-sitosterol, Linolenic Acid and Retinol. Intake of Beta-sitosterol along with Everolimus treatment for Small Cell Lung Cancer causes a decrease in a specific biochemical pathway which is called Cell Cycle, and this is a very positive effect. Beetroot hence should be eaten with Everolimus treatment for Small Cell Lung Cancer. (Tamilselvam Rajavel et al, Sci Rep., 2018; Eva Juengel et al, Mol Cancer., 2014; Igor Tsaur et al, Cancer Lett., 2011)
Bell Pepper : Bell Pepper contains active ingredients like Capsaicin, Dihydrocapsaicin and Linolenic Acid. Intake of Capsaicin along with Everolimus treatment for Small Cell Lung Cancer causes a decrease in a specific biochemical pathway which is called Cell Cycle, and this is a very positive effect. Bell Pepper hence should be eaten with Everolimus treatment for Small Cell Lung Cancer. (N H Thoennissen et al, Oncogene., 2010; Eva Juengel et al, Mol Cancer., 2014; Igor Tsaur et al, Cancer Lett., 2011)
Should I take this Nutritional Supplement with Everolimus treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Everolimus treatment, and hence should not be used. Also, Black Seed supplement interferes with the impact of Everolimus in Small Cell Lung Cancer by decreasing the biochemical pathways such as RAS-RAF Signaling and increasing pathways/processes like Nutrient sensing.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Small Cell Lung Cancer (SCLC)?
In the initial stages, most cancers including Small Cell Lung Cancer (SCLC) may not cause any signs or symptoms. However, as the disease progresses, Small Cell Lung Cancer (SCLC) may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Small Cell Lung Cancer (SCLC).
- Coughing up blood
- Chest pain
- Chronic cough
- Unexplained weight loss
- Loss of appetite
- Facial swelling
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Small Cell Lung Cancer (SCLC).
What are the Treatment Options for Small Cell Lung Cancer (SCLC)?
The treatment for Small Cell Lung Cancer (SCLC) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Small Cell Lung Cancer (SCLC) include:
- Radiation Therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Small Cell Lung Cancer (SCLC).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet, which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Small Cell Lung Cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.