No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Glioblastoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Apricot and Bael should be eaten when undergoing Radiation treatment for Glioblastoma. On the same lines, avoid foods like Black-eyed Pea and Chervil with treatment of Radiation for Glioblastoma.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Glioblastoma.
What is Glioblastoma?
Glioblastoma is a cancer that develops within the brain. The incidence rate of this cancer is 3.21 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 64 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Glioblastoma has a prevalence of certain genetic changes. Some of the genes such as PTEN, TP53, MGMT, and EGFR are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Glioblastoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Glioblastoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Glioblastoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing a diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Glioblastoma nutrition may have to be redesigned.
Why Eating Right Matters for Glioblastoma?
In Glioblastoma, activation or inhibition of some of the biochemical pathways including Mapk Signaling, JAK-STAT Signaling, Cancer Epigenetics, TGFB Signaling, Epithelial To Mesenchymal Transition, Focal Adhesion, Inflammation, Cell Survival, MYC Signaling, Cholesterol Metabolism, DNA Repair, RAS-RAF Signaling, Autophagy, NOTCH Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, NFKB Signaling, Oxidative Stress, Small Molecule Transport and Angiogenesis plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Glioblastoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Radiation treatment for Glioblastoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Glioblastoma considering one specific treatment – Radiation.
Foods to Avoid with Radiation treatment
Black-eyed Pea : Black-eyed Pea contains active ingredients such as Retinol, Genistein, Folic Acid and others. Retinol interferes with the impact of Radiation in Glioblastoma by activating a specific biochemical pathway/process called Focal Adhesion. Hence, avoid eating foods like Black-eyed Pea with Radiation treatment for Glioblastoma.
Chervil : Chervil contains active ingredients such as Linolenic Acid, Retinol, Linoleic Acid and others. Linolenic Acid interferes with the impact of Radiation in Glioblastoma by blocking a specific biological process called Oxidative Stress. Hence, avoid eating foods like Chervil with Radiation treatment for Glioblastoma.
Foods to Eat with Radiation treatment
Apricot : Apricot contains active ingredients like Epicatechin, Modified Citrus Pectin and Linolenic Acid. Intake of Epicatechin along with Radiation treatment for Glioblastoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Apricot hence should be eaten with Radiation treatment for Glioblastoma. (Olga C J Schuurbiers et al, J Thorac Oncol., 2009; Mahmoud Toulany et al, Mol Cancer Ther., 2008; Shi Liu et al, Am J Chin Med., 2013)
Bael : Bael contains active ingredients like Auraptene, Chlorogenic Acid and Linolenic Acid. Intake of Auraptene along with Radiation treatment for Glioblastoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bael hence should be eaten with Radiation treatment for Glioblastoma. (Khadijeh Jamialahmadi et al, J Pharmacopuncture., 2018; Olga C J Schuurbiers et al, J Thorac Oncol., 2009; Mahmoud Toulany et al, Mol Cancer Ther., 2008)
Should I take this Nutritional Supplement with Radiation treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Radiation treatment. Black Seed supports the Radiation treatment for Glioblastoma by decreasing the biochemical pathways or processes called Angiogenesis, Cell Survival, Epithelial to Mesenchymal Transition, MAPK Signaling, Focal Adhesion, JAK-STAT Signaling, MYC Signaling, NFKB Signaling, Inflammation, Notch Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, DNA Repair, Cholesterol Metabolism, TGFB Signaling, Cancer Epigenetics, RAS-RAF Signaling and increasing pathways like Oxidative Stress.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Glioblastoma?
As the disease progresses, Glioblastoma may start showing one or more symptoms. Based on the exact location of Glioblastoma, the signs or symptoms may vary.
Following are some of the signs and symptoms that may be caused by Glioblastoma.
- Persistent headaches
- Lack of appetite
- Personality and mood changes
- Double vision or blurred vision
- Speech difficulty
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Glioblastoma.
What are the Treatment Options for Glioblastoma?
The treatment for Glioblastoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Glioblastoma include:
- Radiation therapy
- Targeted drug therapy.
Surgery or surgery followed by radiation is usually the first treatment regimen for Glioblastoma. Radiotherapy helps to shrink the tumor. Chemotherapy with the drug temozolomide is the standard of care treatment for glioblastoma. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Glioblastoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Glioblastoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.