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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Rooibos Supplement?

Jul 31, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Rooibos have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Rooibos supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Rooibos supplements can benefit cancer patients with Parathyroid Carcinoma on Radiation treatment. But avoid Rooibos supplements if on Ibrutinib treatment for Waldenstrom Macroglobulinemia (Relapsed Refractory). Similarly, taking nutritional supplement Rooibos can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene KIT. But avoid taking nutritional supplement Rooibos when at genetic risk of cancer due to mutation of gene MRE11.

The takeaway being – your individual context will influence your decision if nutritional supplement Rooibos is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Rooibos based on individual context and conditions. 

Rooibos Supplements for Cancer Treatment and Genetic Risk

So the question is should you take the supplement Rooibos? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene KIT? Should you take it when diagnosed with Waldenstrom Macroglobulinemia (Relapsed Refractory)? Should you take the Rooibos supplement when diagnosed with Parathyroid Carcinoma? Should you take it when on Ibrutinib treatment? Should you continue taking Rooibos supplement if you change your treatment from Ibrutinib to Radiation? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Rooibos. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Waldenstrom Macroglobulinemia (Relapsed Refractory) or Parathyroid Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Rooibos.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Rooibos? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene KIT? Are the implications of taking Rooibos supplement in Waldenstrom Macroglobulinemia (Relapsed Refractory) the same as Parathyroid Carcinoma? Is it one and the same if you are on treatment Ibrutinib or on Radiation?

Rooibos – A Nutritional Supplement

Rooibos (Aspalathus linearis) is a herb native to South Africa.The fermented leaves of the Aspalathus linearis is used to make Rooibos tea. It is considered to have strong antioxidant properties. Following are some of the potential health benefits of Rooibos:

Rooibos supplements contain many active ingredients including Caffeic acid, Gallic acid, Luteolin, Quercetin, Rutin, Isovitexin, Myrcene, Chrysoeriol and Cinnamic Acid at different concentration levels. The molecular pathways which are regulated by Rooibos include G-protein-coupled Receptor Signaling, PI3K-AKT-MTOR Signaling, Estrogen Signaling, Stem Cell Signaling and MYC Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Rooibos individually or in combination is an important decision to be made. When making decisions on the use of supplement Rooibos for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Rooibos use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Rooibos Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Rooibos for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Rooibos may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Rooibos should be avoided or not and why.

1. Will Rooibos Supplements benefit Waldenstrom Macroglobulinemia (Relapsed Refractory) Patients undergoing Ibrutinib Cancer treatment?

Waldenstrom Macroglobulinemia (Relapsed Refractory) is characterized and driven by specific genetic mutations like BTK and TBL1XR1 leading to biochemical pathway changes in G-protein-coupled Receptor Signaling, MYC Signaling, NFKB Signaling, B Cell Receptor Signaling and Phospholipase Signaling. A cancer treatment like Ibrutinib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Rooibos should be avoided for Waldenstrom Macroglobulinemia (Relapsed Refractory) along with treatment Ibrutinib. Rooibos impacts pathways/processes like G-protein-coupled Receptor Signaling and MYC Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Rooibos supplements contain active ingredients like Caffeic acid, Gallic acid, Luteolin, Quercetin, Rutin, Isovitexin and Myrcene which have CYP3A4/CYP3A5 interactions with Ibrutinib treatment, and hence should be avoided by patients undergoing this treatment. (Himanshu Rastogi and Snehasis Jana et al, Phytother Res., 2014; https://patents.google.com/patent/US7169763B2/en; Luigi Quintieri et al, Biochem Pharmacol., 2008; Sedar Karakurt et al, Acta Pharm., 2016; Omer I Fantoukh et al, J Agric Food Chem., 2019; https://patents.google.com/patent/US7169763B2/en) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Rooibos Supplements benefit Cancer Patients with Parathyroid Carcinoma undergoing Radiation Treatment?

Parathyroid Carcinoma is characterized and driven by specific genetic mutations like CDC73 and RAD50 leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Epithelial to Mesenchymal Transition, Cell Cycle Checkpoints and DNA Repair. A cancer treatment like Radiation works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Rooibos supplements should be considered for Parathyroid Carcinoma along with treatment Radiation. Rooibos supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling and RAS-RAF Signaling which either obstruct drivers of Parathyroid Carcinoma and/or improve Radiation treatment effect. 

For Which Cancer to Avoid taking Supplement Rooibos

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Rooibos Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing. 

MRE11 mutation causes biochemical pathways/processes like Estrogen Signaling, Growth Factor Signaling, Stem Cell Signaling, Interferon Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Rooibos should be avoided when the genetic panel identifies the mutation of MRE11 for Breast Cancer. Rooibos impacts pathways/processes like Estrogen Signaling and Growth Factor Signaling and creates adverse effects with MRE11 and related conditions.

4. Are Rooibos Supplements Safe for Healthy Individuals with KIT Mutation Associated Genetic Risk?

KIT is one of the genes available in panels for cancer risk testing. KIT mutation causes biochemical pathways/processes like Stem Cell Signaling, PI3K-AKT-MTOR Signaling, RUNX Signaling, JAK-STAT Signaling and RAS-RAF Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Rooibos supplements when the genetic panel identifies mutation in KIT for Gastric Cancer and Hematological Cancer. Rooibos impacts pathways/processes like Stem Cell Signaling and PI3K-AKT-MTOR Signaling and creates a supportive effect in those with KIT mutation and related conditions.

Which Cancer Types to Avoid Rooibos Supplement

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Rooibos, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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