Nutritional supplements like Perilla have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Perilla supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Perilla supplements can benefit cancer patients with Juvenile Myelomonocytic Leukemia on Trametinib treatment. But avoid Perilla supplements if on Carmustine treatment for Pineoblastoma. Similarly, taking nutritional supplement Perilla can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene SDHAF2. But avoid taking nutritional supplement Perilla when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Perilla is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Perilla based on individual context and conditions.
So the question is should you take the supplement Perilla? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene SDHAF2? Should you take it when diagnosed with Pineoblastoma? Should you take Perilla supplements when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Carmustine treatment? Should you continue taking Perilla supplements if you change your treatment from Carmustine to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Perilla.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Pineoblastoma or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Perilla.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Perilla? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene SDHAF2? Are the implications of taking Perilla supplements in Pineoblastoma the same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Carmustine or on Trametinib?
Perilla – A Nutritional Supplement
Perilla, also known as Shiso, beefsteak plant, Chinese basil, or purple mint, is a member of the Lamiaceae or mint family, native to Asian countries including India, China, Korea and Japan. Perilla oil is rich in omega-3 fatty acid. Following are some of the potential health benefits of Perilla oil:
- May help improve airflow in asthma patients (M Okamoto et al, Int Arch Allergy Immunol., 2000)
- May help improve hypertriglyceridemia (Feng Wang et al, Mol Nutr Food Res., 2018)
- May help reduce cholesterol (Chuntida Kamalashiran et al, Curr Alzheimer Res., 2019)
Perilla supplements contain many active ingredients including Beta-sitosterol, Stigmasterol and Perillaldehyde at different concentration levels. The molecular pathways which are regulated by Perilla include PI3K-AKT-MTOR Signaling, Stem Cell Signaling, DNA Repair, RAS-RAF Signaling and Cell Cycle Checkpoints. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Perilla individually or in combination is an important decision to be made. When making decisions on the use of supplement Perilla for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Perilla use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Perilla Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Perilla for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Perilla may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Perilla should be avoided or not and why.
1. Will Perilla Supplements benefit Cancer Patients with Pineoblastoma undergoing Carmustine treatment?
Pineoblastoma is characterized and driven by specific genetic mutations like ATR and ATM leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, DNA Repair, Cancer Epigenetics and EPHRIN Signaling. A cancer treatment like Carmustine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Perilla should be avoided for Pineoblastoma along with treatment Carmustine. Perilla impacts pathways/processes like PI3K-AKT-MTOR Signaling and DNA Repair which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Perilla Supplements benefit Cancer Patients with Juvenile Myelomonocytic Leukemia undergoing Trametinib Treatment?
Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, JAK-STAT Signaling, MAPK Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Perilla supplements should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Perilla supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling and RAS-RAF Signaling which either obstruct drivers of Juvenile Myelomonocytic Leukemia and/or improve Trametinib treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Perilla Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like Stem Cell Signaling, Cell Cycle Checkpoints, RUNX Signaling, JAK-STAT Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Perilla should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Perilla impacts pathways/processes like Stem Cell Signaling and Cell Cycle Checkpoints and creates adverse effects with TERT and related conditions.
4. Are Perilla Supplements Safe for Healthy Individuals with SDHAF2 Mutation Associated Genetic Risk?
SDHAF2 is one of the genes available in panels for cancer risk testing. SDHAF2 mutation causes biochemical pathways/processes like Stem Cell Signaling, Hypoxia, Angiogenesis, Cancer Epigenetics and Carbohydrate Metabolism to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Perilla supplements when the genetic panel identifies mutation in SDHAF2 for Thyroid Cancer and Neuroendocrine Cancer. Perilla impacts pathways/processes like Stem Cell Signaling and Hypoxia and creates a supportive effect in those with SDHAF2 mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Perilla, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.