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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Kaempferol Supplement?

Jun 18, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Kaempferol have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Kaempferol supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Kaempferol supplements can benefit cancer patients with B Cell Acute Lymphoblastic Leukemia (B-ALL) on Car-t treatment. But avoid Kaempferol supplements if on Dexamethasone treatment for Aggressive Natural Killer Cell Leukemia. Similarly, taking nutritional supplement Kaempferol can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDK4. But avoid taking nutritional supplement Kaempferol when at genetic risk of cancer due to mutation of gene CDH1.

The takeaway being – your individual context will influence your decision if nutritional supplement Kaempferol is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Kaempferol based on individual context and conditions.

Kaempferol Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Kaempferol? Should you take it when at genetic risk of cancer for mutation of gene CDH1? Should you take it when at genetic risk of cancer for mutation of gene CDK4? Should you take it when diagnosed with Aggressive Natural Killer Cell Leukemia? Should you take Kaempferol supplement when diagnosed with B Cell Acute Lymphoblastic Leukemia (B-ALL)? Should you continue taking it if you change your treatment from Dexamethasone to Car-t? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Kaempferol. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Aggressive Natural Killer Cell Leukemia or B Cell Acute Lymphoblastic Leukemia (B-ALL), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Kaempferol.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Kaempferol? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDH1 the same as due to mutation of gene CDK4? Are the implications of taking Kaempferol supplement in Aggressive Natural Killer Cell Leukemia same as B Cell Acute Lymphoblastic Leukemia (B-ALL)? Is it one and the same if you are on treatment with Dexamethasone or on Car-t? 

Kaempferol – A Nutritional Supplement

Kaempferol is a type of flavonoid found in fruits and vegetables. It possesses strong antioxidant properties which protects the cells and their DNA from oxidative damage. The benefits of consuming Kaempferol are: (Hong Feng at al, Planta Med. 2017

  • May have protective effect on the heart 
  • May be used for treatment of atherosclerosis
  • May help in controlling diabetes
  • May possesses anti-inflammatory effect
  • May have anticancer properties (Allen Y. Chen at al, Food Chem. 2013)

Kaempferol is an active ingredient found in various food items. Blackberry, Elderberry and Peach contain Kaempferol at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Kaempferol include MYC Signaling, Hypoxia, WNT Beta Catenin Signaling, Cell Cycle and NFKB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Kaempferol individually or in combination is an important decision to be made. When making decisions on the use of supplement Kaempferol for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Kaempferol use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Kaempferol Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Kaempferol for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Kaempferol may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Kaempferol should be avoided or not and why.

1. Will Kaempferol Supplements benefit Cancer Patients with Aggressive Natural Killer Cell Leukemia undergoing Dexamethasone treatment?

Aggressive Natural Killer Cell Leukemia is characterized and driven by specific genetic mutations like DDX3X and STAT3 leading to biochemical pathway changes in WNT Beta Catenin Signaling, MYC Signaling, Interferon Signaling, JAK-STAT Signaling and MAPK Signaling. A cancer treatment like Dexamethasone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Kaempferol supplement should be avoided for Aggressive Natural Killer Cell Leukemia along with treatment Dexamethasone. Kaempferol supplement impacts pathways/processes like WNT Beta Catenin Signaling which either promote drivers of the Aggressive Natural Killer Cell Leukemia and/or nullify the treatment effect. Additionally, Kaempferol has CYP3A4 interaction with the Dexamethasone treatment, and hence should be avoided. (Drug Interactions Flockhart Table, Pubchem assay) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Kaempferol Supplements benefit Cancer Patients with B Cell Acute Lymphoblastic Leukemia (B-ALL) undergoing Car-T Treatment?

B Cell Acute Lymphoblastic Leukemia (B-ALL) is characterized and driven by specific genetic mutations like TP53 and KMT2D leading to biochemical pathway changes in Hypoxia, NFKB Signaling, PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. A cancer treatment like Car-T works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Kaempferol supplement should be considered for B Cell Acute Lymphoblastic Leukemia (B-ALL) along with treatment Car-T. Kaempferol supplement impacts pathways/processes like Hypoxia and NFKB Signaling which either obstruct drivers of the B Cell Acute Lymphoblastic Leukemia (B-ALL) and/or improve the treatment effect.

For Which Cancer to Avoid taking Supplement Kaempferol

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Kaempferol Supplements Safe for Healthy Individuals with CDH1 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. CDH1 is one of the genes generally available in panels for cancer risk testing.

CDH1 mutation causes biochemical pathways WNT Beta Catenin Signaling, Stem Cell Signaling, Adherens junction, Epithelial to Mesenchymal Transition and Estrogen Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Kaempferol supplement should be avoided when the genetic panel identifies mutation of CDH1 for Breast Cancer and Gastric Cancer. Kaempferol supplement impacts pathways/processes like WNT Beta Catenin Signaling and Stem Cell Signaling and creates adverse effects with CDH1 and related conditions.

4. Are Kaempferol Supplements Safe for Healthy Individuals with CDK4 Mutation Associated Genetic Risk?

CDK4 is one of the genes available in panels for cancer risk testing. CDK4 mutation causes biochemical pathways Cell Cycle, Stem Cell Signaling, MAPK Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Kaempferol supplement when the genetic panel identifies mutation in CDK4 for Skin Cancer. Kaempferol supplement impacts pathways/processes like Cell Cycle and Stem Cell Signaling and creates a supportive effect in those with CDK4 mutation and related conditions.

For Which Cancer Types to Avoid Kaempferol Supplement

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Kaempferol, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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