Nutritional supplements like Cranesbill have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Cranesbill supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Cranesbill supplements can benefit Oropharyngeal Cancer patients on Docetaxel treatment. But avoid Cranesbill supplements if on Ifosfamide treatment for Seminoma. Similarly, taking nutritional supplement Cranesbill can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene STK11. But avoid taking nutritional supplement Cranesbill when at genetic risk of cancer due to mutation of gene MEN1.
The takeaway being – your individual context will influence your decision if nutritional supplement Cranesbill is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Cranesbill based on individual context and conditions.
So the question is should you take the supplement Cranesbill? Should you take it when at genetic risk of cancer for mutation of gene MEN1? Should you take it when at genetic risk of cancer for mutation of gene STK11? Should you take it when diagnosed with Seminoma? Should you take Cranesbill supplement when diagnosed with Oropharyngeal Cancer? Should you take it when on Ifosfamide treatment? Should you continue taking it if you change your treatment from Ifosfamide to Docetaxel? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Cranesbill.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Seminoma or Oropharyngeal Cancer, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Cranesbill.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Cranesbill? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MEN1 the same as due to mutation of gene STK11? Are the implications of Seminoma same as Oropharyngeal Cancer? Is it one and the same if you are on treatment with Ifosfamide or on Docetaxel?
Cranesbill – A Nutritional Supplement
Cranesbill is a perennial plant from the genus Geranium, native to North America. The plant is rich in proanthocyanidins which are known to have antioxidant, antiinflammatory, antiviral, and antibacterial properties. (Perla D. Maldonado et al, J. Agric. Food Chem., 2005). It has been traditionally used for various conditions including the following:
- For abnormal menstruation-related bleeding and other uterine problems
- As a mouth rinse for relieving pain related to canker sores (Meghashyam Bhat, British Dental Journal, 2007)
- For reducing inflammation
- For reducing fever
- For gastro-intestinal problems
Cranesbill supplements contain many active ingredients including Geraniin at different concentration levels. The molecular pathways which are regulated by Cranesbill include Oxidative Stress, Epithelial to Mesenchymal Transition, Vitamin D Signaling, JAK-STAT Signaling and Inflammation. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Cranesbill individually or in combination is an important decision to be made. When making decisions on the use of supplement Cranesbill for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Cranesbill use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Cranesbill Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Cranesbill for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Cranesbill may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Cranesbill should be avoided or not and why.
1. Will Cranesbill Supplements benefit Cancer Patients with Seminoma undergoing Ifosfamide treatment?
Seminoma is characterized and driven by specific genetic mutations like KIT and KRAS leading to biochemical pathway changes in Oxidative Stress, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MAPK Signaling. A cancer treatment like Ifosfamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Cranesbill should be avoided for Seminoma along with treatment Ifosfamide. Cranesbill impacts pathways/processes like Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Cranesbill Supplements benefit Oropharyngeal Cancer Patients undergoing Docetaxel Treatment?
Oropharyngeal Cancer is characterized and driven by specific genetic mutations like TP53 and PIK3CA leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, Inflammation, Hypoxia, PI3K-AKT-MTOR Signaling and P53 Signaling. A cancer treatment like Docetaxel works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Cranesbill supplements should be considered for Oropharyngeal Cancer along with treatment Docetaxel. Cranesbill supplement impacts pathways/processes like Epithelial to Mesenchymal Transition and Inflammation which either obstruct drivers of Oropharyngeal Cancer and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Cranesbill Supplements Safe for Healthy Individuals with MEN1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MEN1 is one of the genes generally available in panels for cancer risk testing.
MEN1 mutation causes biochemical pathways/processes like Vitamin D Signaling, Stem Cell Signaling, NFKB Signaling, MAPK Signaling and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cranesbill should be avoided when the genetic panel identifies mutation of MEN1 for Thyroid Cancer and Neuroendocrine Cancer. Cranesbill impacts pathways/processes like Vitamin D Signaling and Stem Cell Signaling and creates adverse effects with MEN1 and related conditions.
4. Are Cranesbill Supplements Safe for Healthy Individuals with STK11 Mutation Associated Genetic Risk?
STK11 is one of the genes available in panels for cancer risk testing. STK11 mutation causes biochemical pathways/processes like Oxidative Stress, Autophagy, Nucleotide metabolism, Insulin Signaling and Estrogen Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Cranesbill supplement when the genetic panel identifies mutation in STK11 for Breast Cancer and Colon Cancer. Cranesbill impacts pathways/processes like Oxidative Stress and Autophagy and creates an additive effect with STK11 and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Cranesbill, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.