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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Skullcap Supplement?

Jun 11, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Skullcap have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Skullcap supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Skullcap supplements can benefit cancer patients with Renal Non-Clear Cell Carcinoma on Bevacizumab treatment. But avoid Skullcap supplements if on Decitabine treatment for TET2 +ve Chronic Myelomonocytic Leukemia. Similarly, taking nutritional supplement Skullcap can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Skullcap when at genetic risk of cancer due to mutation of gene TERT.

The takeaway being – your individual context will influence your decision if nutritional supplement Skullcap is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Skullcap based on individual context and conditions.

Skullcap Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Skullcap? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with TET2 +ve Chronic Myelomonocytic Leukemia? Should you take Skullcap supplement when diagnosed with Renal Non-Clear Cell Carcinoma? Should you take it when on Decitabine treatment? Should you continue taking it if you change your treatment from Decitabine to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Skullcap. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as TET2 +ve Chronic Myelomonocytic Leukemia or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Skullcap.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Skullcap? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene MAX? Are the implications of TET2 +ve Chronic Myelomonocytic Leukemia same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment with Decitabine or on Bevacizumab? 

Skullcap – A Nutritional Supplement

Skullcap belongs to the mint family. There are two varieties of skullcap – American and Chinese. The name is derived from scutella which means “little dish”. The American variety of Skullcap leaves have been traditionally used as sedatives. The roots of Skullcap are also used as supplements. Following are some of the potential benefits of skullcap:

Skullcap supplements contain many active ingredients including Baicalein, Scutellarein and Oroxylin A at different concentration levels. The molecular pathways which are regulated by Skullcap include Cancer Epigenetics, Epithelial to Mesenchymal Transition, MYC Signaling, MAPK Signaling and Hypoxia. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Skullcap individually or in combination is an important decision to be made. When making decisions on the use of supplement Skullcap for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Skullcap use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Skullcap Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Skullcap for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Skullcap may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Skullcap should be avoided or not and why.

1. Will Skullcap Supplements benefit Cancer Patients with TET2 +ve Chronic Myelomonocytic Leukemia undergoing Decitabine treatment?

TET2 +ve Chronic Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like TET2 and ASXL1 leading to biochemical pathway changes in Cancer Epigenetics, mRNA Splicing and MYC Signaling. A cancer treatment like Decitabine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Skullcap supplement  should be avoided for TET2 +ve Chronic Myelomonocytic Leukemia along with Decitabine treatment. Skullcap supplement impacts pathways/processes like Cancer Epigenetics which either promote drivers of Chronic Myelomonocytic Leukemia and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Skullcap Supplements benefit Cancer Patients with Renal Non-Clear Cell Carcinoma undergoing Bevacizumab Treatment?

Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, Oxidative Stress, Hypoxia, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Skullcap supplement should be considered for Renal Non-Clear Cell Carcinoma along with treatment Bevacizumab. Skullcap supplement impacts pathways/processes like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling which either obstruct drivers of the Renal Non-Clear Cell Carcinoma and/or improve the treatment effect.

For Which Cancer to Avoid taking Supplement Skullcap

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Skullcap Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing. 

TERT mutation causes biochemical pathways MYC Signaling, Cancer Epigenetics, Nucleotide metabolism, Stem Cell Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Skullcap supplement should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Skullcap supplement impacts pathways/processes like Cancer Epigenetics and creates adverse effects with TERT and related conditions.

4. Are Skullcap Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?

MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways MAPK Signaling, Cell Cycle, Stem Cell Signaling, MYC Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking a Skullcap supplement when the genetic panel identifies mutations in MAX for Neuroendocrine Cancer. Skullcap supplement impacts pathways/processes like MAPK Signaling and Cell Cycle and creates a supportive effect in those with MAX mutation and related conditions.

For Which Cancer Types to Avoid skullcap Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Skullcap, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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