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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Should I Avoid Buckwheat Supplement?

Jun 1, 2021

Estimated reading time: 8 minutes
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Highlights

Nutritional supplements like Buckwheat have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Buckwheat supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Buckwheat supplements can benefit cancer patients with Rosai-Dorfman disease on Prednisone treatment. But avoid Buckwheat supplements if on Pazopanib treatment for Chronic myeloid leukaemia. Similarly, taking nutritional supplement Buckwheat can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Buckwheat when at genetic risk of cancer due to mutation of gene MRE11.

The takeaway being – your individual context will influence your decision if nutritional supplement Buckwheat is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.


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Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Buckwheat based on individual context and conditions.

Buckwheat Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Buckwheat? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Chronic myeloid leukaemia? Should you take Buckwheat supplement when diagnosed with Rosai-Dorfman disease? Should you take it when on Pazopanib treatment? Should you continue taking it if you change your treatment from Pazopanib to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Buckwheat. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic myeloid leukaemia or Rosai-Dorfman disease, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Buckwheat.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Buckwheat? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MAX? Are the implications of Chronic myeloid leukaemia same as Rosai-Dorfman disease? Is it one and the same if you are on treatment with Pazopanib or on Prednisone? 

Buckwheat – A Nutritional Supplement

Buckwheat is a gluten free and a whole grain cereal which has high nutritional value. It is mainly grown in Russia, Kazakhstan and China where it is considered as a superfood. Buckwheat is rich in fibre which is converted into short chain fatty acid like butyrate by gut bacteria in the colon. The benefits of consuming buckwheat are:

Excess consumption of buckwheat leads to a special kind of allergy resulting in rashes and swelling.

Buckwheat supplements contain many active ingredients including Linoleic Acid, Quercetin and Stigmasterol at different concentration levels. The molecular pathways which are regulated by Buckwheat include Oxidative Stress, MYC Signaling, Stem Cell Signaling, MAPK Signaling and TGFB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Buckwheat individually or in combination is an important decision to be made. When making decisions on the use of supplement Buckwheat for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Buckwheat use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Buckwheat Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Buckwheat for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Buckwheat may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Buckwheat should be avoided or not and why.

1. Will Buckwheat Supplements benefit Cancer Patients with Chronic myeloid leukaemia undergoing Pazopanib treatment?

Chronic myeloid leukaemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Oxidative Stress, TGFB Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Cancer Epigenetics. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Buckwheat should be avoided for Chronic myeloid leukaemia along with treatment Pazopanib. Buckwheat supplement impacts pathways/processes like Oxidative Stress and TGFB Signaling which either promote drivers of the Chronic myeloid leukaemia and/or nullify the treatment effect. Additionally, Buckwheat supplements contain active ingredients like Quercetin which has CYP3A4 interactions with Pazopanib treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; Camille Azam, Eur J Clin Pharmacol.,  2020; Jun-Shik Choi, Arch Pharm Res., 2011) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Buckwheat Supplements benefit Cancer Patients with Rosai-Dorfman disease undergoing Prednisone Treatment?

Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MYC Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Buckwheat supplements should be considered for Rosai-Dorfman disease along with treatment Prednisone. Buckwheat supplement impacts pathways/processes like MYC Signaling and MAPK Signaling which either obstruct drivers of the Rosai-Dorfman disease and/or improve the treatment effect.

For Which Cancer to Avoid taking Supplement Buckwheat

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Buckwheat Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.

MRE11 mutation causes biochemical pathways DNA Repair, Stem Cell Signaling, Angiogenesis, Estrogen Signaling and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Buckwheat should be avoided when the genetic panel identifies a mutation of MRE11 for Breast Cancer. Buckwheat impacts pathways/processes like DNA Repair and creates adverse effects with MRE11 and related conditions.

4. Are Buckwheat Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?

MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways MAPK Signaling, Cell Cycle, Stem Cell Signaling, MYC Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Buckwheat supplement when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Buckwheat impacts pathways/processes like MYC Signaling and Cell Cycle and creates an additive effect with MAX and related conditions.

For Which Cancer Types to Avoid Buckwheat Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Buckwheat, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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