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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

is the most common question asked by cancer patients. Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

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For Which Cancer Types Should I Avoid Maclura Pomifera (Osage Orange) Supplement?

May 24, 2021

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Highlights

Nutritional supplements like Maclura Pomifera (Osage Orange) have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Maclura Pomifera (Osage Orange) supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Maclura Pomifera (Osage Orange) supplements can benefit Bladder Urothelial Carcinoma patients on Vinblastine cancer treatment. But avoid Maclura Pomifera (Osage Orange) supplements if on Prednisone cancer treatment for Rosai-Dorfman disease. Similarly, taking nutritional supplement Maclura Pomifera (Osage Orange) can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN1B. But avoid taking nutritional supplement Maclura Pomifera (Osage Orange) when at genetic risk of cancer due to mutation of gene POLH.

The takeaway being – your individual context will influence your decision if nutritional supplement Maclura Pomifera (Osage Orange) is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 

Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Maclura Pomifera (Osage Orange) based on individual context and conditions. 

Maclura pomifera Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Maclura Pomifera (Osage Orange)? Should you take it when at genetic risk of cancer for mutation of gene POLH? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Rosai-Dorfman disease? Should you take it when diagnosed with Bladder Urothelial Carcinoma? Should you take Maclura Pomifera (Osage Orange) supplement when on Prednisone cancer treatment? Should you continue taking it if you change your treatment from Prednisone to Vinblastine? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Maclura Pomifera (Osage Orange). 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Rosai-Dorfman disease or Bladder Urothelial Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Maclura Pomifera (Osage Orange).

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Maclura Pomifera (Osage Orange)? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene POLH the same as due to mutation of gene CDKN1B? Are the implications of Rosai-Dorfman disease same as Bladder Urothelial Carcinoma? Is it one and the same if you are on treatment Prednisone or on Vinblastine? 

Maclura Pomifera (Osage Orange) – A Nutritional Supplement

Maclura Pomifera is a deciduous tree native to Texas, Oklahoma, and adjacent areas of the southern plains. It is also known as Osage orange, Hedge apple, Bowwood and Monkey Ball Tree. It is considered to have antioxidant and antimicrobial properties. Following are some of the potential health benefits of Maclura Pomifera:

  • May improve heart health
  • May boost immune system function
  • May support overall health due to string antioxidant properties

Maclura Pomifera (Osage Orange) supplements contain many active ingredients including Morin at different concentration levels. (Gurusamy Abirami et al, Front Microbiol., 2020) The molecular pathways which are regulated by Maclura Pomifera (Osage Orange) include MYC Signaling, NFKB Signaling, DNA Repair, Cell Cycle and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Maclura Pomifera individually or in combination is an important decision to be made. When making decisions on the use of supplement Maclura Pomifera for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Maclura Pomifera use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Maclura Pomifera (Osage Orange) Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Maclura Pomifera for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Maclura Pomifera may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Maclura Pomifera should be avoided or not and why.

1. Will Maclura Pomifera (Osage Orange) Supplements benefit Rosai-Dorfman disease Patients undergoing Prednisone Cancer treatment?

Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MYC Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Prednisone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Maclura Pomifera should be avoided for Rosai-Dorfman disease along with treatment Prednisone. Maclura Pomifera impacts pathways/processes like MYC Signaling and MAPK Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Maclura Pomifera (Osage Orange) Supplements benefit Bladder Urothelial Carcinoma Patients undergoing Vinblastine Cancer Treatment?

Bladder Urothelial Carcinoma is characterized and driven by specific genetic mutations like TP53 and MUC16 leading to biochemical pathway changes in NFKB Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling and Small Molecule Transport. A cancer treatment like Vinblastine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Maclura Pomifera should be considered for Bladder Urothelial Carcinoma along with treatment Vinblastine. Maclura Pomifera impacts pathways/processes like NFKB Signaling and Cell Cycle which either obstruct drivers of the disease and/or improve the treatment effect. 

Palliative Care Nutrition for Cancer | When Conventional Treatment is not Working

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

3. Are Maclura Pomifera (Osage Orange) Supplements Safe for Healthy Individuals with POLH Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. POLH is one of the genes generally available in panels for cancer risk testing.

POLH mutation causes biochemical pathways DNA Repair, MAPK Signaling, Stem Cell Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Maclura Pomifera should be avoided when the genetic panel identifies mutation of POLH for Skin Cancer. Maclura Pomifera impacts pathways/processes like DNA Repair and MAPK Signaling and creates adverse effects with POLH and related conditions.

4. Are Maclura Pomifera (Osage Orange) Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?

CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways/processes like Cell Cycle, Cell Cycle Checkpoints, Stem Cell Signaling, FOXO Signaling and PI3K-AKT-MTOR Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Maclura Pomifera  supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Maclura Pomifera impacts pathways/processes like Cell Cycle and Cell Cycle Checkpoints and creates a supportive effect in those with CDKN1B and related conditions. 

Which Cancer Types to Avoid Maclura Pomifera Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Maclura Pomifera, is an effective tool which can be controlled by you, while facing cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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