Nutritional supplements like Goldenseal have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Goldenseal supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Goldenseal supplements can benefit Renal Non-Clear Cell Carcinoma patients on Bevacizumab cancer treatment. But avoid Goldenseal supplements if on Pazopanib treatment for Chronic Myeloid Leukemia. Similarly, taking nutritional supplement Goldenseal can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Goldenseal when at genetic risk of cancer due to mutation of gene MRE11.
The takeaway being – your individual context will influence your decision if nutritional supplement Goldenseal is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Goldenseal based on individual context and conditions.
So the question is should you take the supplement Goldenseal? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Chronic Myeloid Leukemia? Should you take Goldenseal supplement when diagnosed with Renal Non-Clear Cell Carcinoma? Should you take it when on Pazopanib treatment? Should you continue taking it if you change your treatment from Pazopanib to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Goldenseal.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic Myeloid Leukemia or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Goldenseal.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Goldenseal? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MAX? Are the implications of Chronic Myeloid Leukemia same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment Pazopanib or on Bevacizumab?
Goldenseal – A Nutritional Supplement
Goldenseal, also known as orangeroot or yellow puccoon, is a perennial herb native to North America. The roots and leaves of goldenseal are considered to have antimicrobial, antioxidant and anti-inflammatory properties and have been used as a herbal medicine across the world mainly to combat infections and inflammation. Traditionally, goldenseal was used for fevers, ulcers, skin disorders and other health conditions.The dietary supplements of Goldenseal are also widely used in the United States and other regions for common cold and other respiratory problems, though its effectiveness on these conditions is unclear.
Goldenseal is known to have CYP interactions with many medications. Hence, these supplements should be taken only after consulting with your doctor.
Goldenseal supplements contain many active ingredients including Hydrastine, Canadine, Neochlorogenic acid, Palmatine, Coptisine, Jatrorrhizine and Berberine at different concentration levels. The molecular pathways which are regulated by Goldenseal include Oxidative Stress, Epithelial to Mesenchymal Transition, DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Goldenseal individually or in combination is an important decision to be made. When making decisions on the use of supplement Goldenseal for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Goldenseal use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Goldenseal Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Goldenseal for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Goldenseal may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Goldenseal should be avoided or not and why.
1. Will Goldenseal Supplements benefit Chronic Myeloid Leukemia Patients undergoing Pazopanib Cancer treatment?
Chronic myeloid Leukemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Oxidative Stress, Growth Factor Signaling, Cancer Epigenetics and RUNX Signaling. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Goldenseal should be avoided for Chronic Myeloid Leukemia along with treatment Pazopanib. Goldenseal impacts pathways like Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Goldenseal supplements are known to have CYP3A4 (drug metabolizing enzyme) interactions with Pazopanib treatment, and hence should be avoided by cancer patients undergoing this treatment. (Ranjeev S Sandhu et al, J Clin Pharmacol., 2003; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Goldenseal Supplements benefit Renal Non-Clear Cell Carcinoma Patients undergoing Bevacizumab Cancer Treatment?
Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, MAPK Signaling, PI3K-AKT-MTOR Signaling and Small Molecule Transport. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Goldenseal supplement should be considered for Renal Non-Clear Cell Carcinoma along with treatment Bevacizumab. Goldenseal supplement impacts pathways like Epithelial to Mesenchymal Transition and MAPK Signaling which either obstruct drivers of the disease (Renal Non-Clear Cell Carcinoma) and/or improve the treatment effect.
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3. Are Goldenseal Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.
MRE11 mutation causes biochemical pathways DNA Repair, Growth Factor Signaling, Estrogen Signaling, Stem Cell Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Goldenseal should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Goldenseal impacts pathways like DNA Repair and Growth Factor Signaling and creates adverse effects with MRE11 and related conditions.
4. Are Goldenseal Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?
MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways MAPK Signaling, Cell Cycle, Stem Cell Signaling, MYC Signaling and Cancer Epigenetics to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Goldenseal supplements when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Goldenseal impacts pathways like MAPK Signaling and Cell Cycle and creates a supportive effect in those with MAX and related conditions.
* Other Factors are also included Like Bmi, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Goldenseal, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.