Nutritional supplements like Broccoli have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Broccoli supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Broccoli supplements can benefit Primary Central Nervous System Lymphoma cancer patients on Epirubicin treatment. But avoid Broccoli supplements if on Paclitaxel treatment for Adenoid Cystic Carcinoma. Similarly, taking nutritional supplement Broccoli can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene SDHAF2. But avoid taking nutritional supplement Broccoli when at genetic risk of cancer due to mutation of gene FLCN.
The takeaway being – your individual context will influence your decision if nutritional supplement Broccoli is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Broccoli based on individual context and conditions.
So the question is should you take supplement Broccoli? Should you take it when at genetic risk of cancer for mutation of gene FLCN? Should you take it when at genetic risk of cancer for mutation of the gene SDHAF2? Should you take it when diagnosed with Adenoid Cystic Carcinoma? Should you take it when diagnosed with Primary Central Nervous System Lymphoma? Should you take it when on Paclitaxel treatment? Should you continue taking Broccoli supplement if you change your treatment from Paclitaxel to Epirubicin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Broccoli.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Adenoid Cystic Carcinoma or Primary Central Nervous System Lymphoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Broccoli.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Broccoli? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene FLCN the same as due to mutation of gene SDHAF2? Are the implications of Adenoid Cystic Carcinoma same as Primary Central Nervous System Lymphoma? Is it one and the same if you are on treatment with Paclitaxel or Epirubicin?
Broccoli – A Nutritional Supplement
Broccoli is an edible green vegetable that belongs to cruciferous vegetables such as cabbage, kale, cauliflower, Brussels sprouts, bok choy, and turnips. Broccoli is high in fibre and highly nutritious with many health benefits. Following are some of the general health benefits of broccoli:
- May help in reduce inflammation
- May help reduce blood sugar
- May help improve heart health and brain functioning
- May help keep bones and joints healthy
- May help in weight loss
Broccoli is also available in the form of dietary supplements.
Broccoli supplements contain many active ingredients including Sulforaphane, Indole-3-carbinol, Salicylic Acid, Retinol, Kaempferol, Vitamin C and Brassinin at different concentration levels. The molecular pathways which are regulated by Broccoli include Focal Adhesion, Cell Survival, PI3K-AKT-MTOR Signaling, Hypoxia and Carbohydrate Metabolism. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Broccoli individually or in combination is an important decision to be made. When making decisions on the use of supplement Broccoli for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Broccoli use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Broccoli Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Broccoli for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Broccoli may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Broccoli should be avoided or not and why.
1. Will Broccoli Supplements benefit Adenoid Cystic Carcinoma Cancer Patients undergoing Paclitaxel treatment?
Adenoid Cystic Carcinoma is characterized and driven by specific genetic mutations like NFIB and MYB leading to biochemical pathway changes in Focal Adhesion, PI3K-AKT-MTOR Signaling, Notch Signaling and Cholesterol Metabolism. A cancer treatment like Paclitaxel works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Broccoli should be avoided for Adenoid Cystic Carcinoma along with treatment Paclitaxel. Broccoli impacts pathways like Focal Adhesion which either promote drivers of the disease and/or nullify the treatment effect. Additionally, broccoli also contains key active ingredients like Retinol and Kaempferol which have CYP3A4 (drug metabolizing enzymes) interactions with Paclitaxel treatment, and hence should be avoided by cancer patients undergoing this treatment. (Kun Wang et al, Biochem Pharmacol., 2008; Fang-fang Zhang et al, Zhejiang Da Xue Xue Bao Yi Xue Ban., 2006; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Broccoli Supplements benefit Primary Central Nervous System Lymphoma Cancer Patients undergoing Epirubicin Treatment?
Primary Central Nervous System Lymphoma is characterized and driven by specific genetic mutations like MYD88 and CD79B leading to biochemical pathway changes in Cell Survival, Cell Cycle, Apoptosis, NFKB Signaling and B Cell Receptor Signaling. A cancer treatment like Epirubicin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Broccoli supplements should be considered for Primary Central Nervous System Lymphoma along with treatment Epirubicin. Broccoli supplement impacts pathways/processes like Cell Survival and Cell Cycle which either obstruct drivers of the disease and/or improve the Epirubicin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Broccoli Supplements Safe for Healthy Individuals with FLCN Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. FLCN is one of the genes generally available in panels for cancer risk testing.
FLCN mutation causes biochemical pathways PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Endoplasmic Reticulum Stress, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Broccoli should be avoided when the genetic panel identifies mutation of FLCN for Kidney Cancer. Broccoli impacts pathways like PI3K-AKT-MTOR Signaling and Stem Cell Signaling and creates adverse effects with FLCN and related conditions.
4. Are Broccoli Supplements Safe for Healthy Individuals with SDHAF2 Mutation Associated Genetic Risk?
SDHAF2 is one of the genes available in panels for cancer risk testing. SDHAF2 mutation causes biochemical pathways Hypoxia, Cancer Epigenetics, Stem Cell Signaling, Carbohydrate Metabolism and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Broccoli supplements when the genetic panel identifies mutation in SDHAF2 for Thyroid Cancer and Neuroendocrine Cancer. Broccoli impacts pathways like Hypoxia and Cancer Epigenetics and creates a supportive effect in those withSDHAF2 and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Broccoli, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.