Nutritional supplements like Apple have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Apple supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Apple supplements can benefit Juvenile Myelomonocytic Leukemia patients on Trametinib treatment. But avoid Apple supplements if on Cisplatin treatment for Hepatoblastoma. Similarly, taking nutritional Apple supplement can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN1B. But avoid taking nutritional Apple supplement when at genetic risk of cancer due to mutation of gene GATA2.
The takeaway being – your individual context will influence your decision if nutritional Apple supplement is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Apple based on individual context and conditions.
So the question is should you take Apple supplement? Should you take it when at genetic risk of cancer for mutation of gene GATA2? Should you take Apple supplement when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Hepatoblastoma? Should you take it when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take Apple supplement when on Cisplatin treatment? Should you continue taking Apple supplement if you change your treatment from Cisplatin to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Apple.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Hepatoblastoma or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Apple.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Apple supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene GATA2 the same as due to mutation of gene CDKN1B? Are the implications of Hepatoblastoma same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Cisplatin or Trametinib?
Apple – A Nutritional Supplement
Apple, a very popular fruit consumed across the world, is highly nutritious with several health benefits. Apples are also available in the form of dietary supplements. However, dietary apple supplements contain high concentrations of the active ingredients as compared to the raw fruit.
Apple supplements contain many active ingredients including Caffeic acid, Chlorogenic acid, Cianidanol, Epicatechin, Estragole, Fisetin, Vitamin C, Modified Citrus Pectin, Quercitrin, Potassium and others at different concentration levels. The molecular pathways which are regulated by Apple supplements include WNT Beta-catenin Signaling, RAS-RAF Signaling, Cancer Epigenetics, FOXO Signaling and Oxidative Stress. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Apple individually or in combination is an important decision to be made. When making decisions on the use of Apple supplements for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Apple supplement use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Apple Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Apple Supplements for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Apple supplements may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Apple supplements should be avoided or not and why.
1. Will Apple Supplements benefit Hepatoblastoma Cancer Patients undergoing Cisplatin treatment?
Hepatoblastoma is characterized and driven by specific genetic mutations like CTNNB1 and NCOA3 leading to biochemical pathway changes in WNT Beta-catenin Signaling, Oxidative Stress, Epithelial to Mesenchymal Transition and Adherens junction. A cancer treatment like Cisplatin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Apple supplements should be avoided for Hepatoblastoma along with treatment Cisplatin. Apple supplements impact pathways WNT Betacatenin Signaling and Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Apple supplements also contain key active ingredients like caffeic acid which have CYP3A4 (drug metabolizing enzymes) interactions with Cisplatin treatment and hence should be avoided. (Loai Basheer et al, Oxid Med Cell Longev., 2015; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Apple Supplements benefit Juvenile Myelomonocytic Leukemia Patients undergoing Trametinib Treatment?
Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Apple supplements should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Apple supplements impact pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of the disease and/or improve the Trametinib treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Apple Supplements Safe for Healthy Individuals with GATA2 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. GATA2 is one of the genes generally available in panels for cancer risk testing.
GATA2 mutation causes biochemical pathways Cancer Epigenetics, Angiogenesis, Hypoxia, Stem Cell Signaling and Nucleotide metabolism to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Apple supplements should be avoided when the genetic panel identifies mutation of GATA2 for Hematological Cancer. Apple supplements impact pathways Cancer Epigenetics and Angiogenesis and create adverse effects with GATA2 and related conditions.
4. Are Apple Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?
CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways FOXO Signaling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Apple supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Apple supplements impact the pathways FOXO Signaling and PI3K-AKT-MTOR Signaling and create a supportive effect in those with CDKN1B and related conditions.
*Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Apple, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.