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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Malignant Peripheral Nerve Sheath Tumor (MPNST)?

Apr 21, 2021

Home » Blogs » Which 3 Foods to Avoid for Malignant Peripheral Nerve Sheath Tumor (MPNST)?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Malignant Peripheral Nerve Sheath Tumor (MPNST) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Basil and Cabbage should be eaten when undergoing Trametinib treatment for Malignant Peripheral Nerve Sheath Tumor. On the same lines, foods like Barley and Green Bean should be avoided with treatment of Trametinib for Malignant Peripheral Nerve Sheath Tumor. 

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Malignant Peripheral Nerve Sheath Tumor.



What is Malignant Peripheral Nerve Sheath Tumor (MPNST)?

Malignant Peripheral Nerve Sheath Tumor is a rare soft tissue sarcoma that develops from the cells that form the sheath which covers and protects peripheral nerves. The incidence rate of this cancer is only 0.2 per 1 lakh people per year. This cancer is commonly diagnosed in people between 20-40 years of age, however, it can occur in people of any age. It is more commonly found in Black population as compared to White population.

Malignant Peripheral Nerve Sheath Tumor - MPNST - Symptoms, Treatment, Diet, Foods

MPNST has prevalence of certain genetic changes. Some of the genes such as NF1, LRP1B, HDAC4, and CHD1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in MPNST can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for MPNST. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Malignant Peripheral Nerve Sheath Tumor genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Malignant Peripheral Nerve Sheath Tumor?

In this cancer, activation or inhibition of some of the biochemical pathways including MAPK Signaling, Growth Factor Signaling, DNA Repair, RAS-RAF Signaling, Angiogenesis, Notch Signaling, Inositol Phosphate Signaling, MYC Signaling, C-type Lectin Receptor Signaling, Wnt Beta-catenin Signaling, Epithelial To Mesenchymal Transition, TGFB Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of MPNST, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Trametinib treatment for Malignant Peripheral Nerve Sheath Tumor

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Malignant Peripheral Nerve Sheath Tumor considering only one specific treatment.

Foods to Avoid

Barley : Barley contains active ingredients such as Esculin, Folic Acid, Oleic Acid and others. Esculin interferes with the impact of Trametinib in MPNST by activating a specific biological process called DNA Repair. Hence, do not eat Barley with Trametinib treatment for this cancer.

Green Bean : Green Bean contains active ingredients such as Ferulic Acid, Folic Acid, Oleic Acid and others. Ferulic Acid interferes with the impact of Trametinib in MPNST by activating a specific biochemical pathway called Growth Factor Signaling. Hence, do not eat Green Bean with Trametinib treatment for this cancer.

Foods to Eat

Basil :  Basil contains active ingredients like D-limonene, P-coumaric Acid, Isoeugenol. Intake of D-limonene along with Trametinib treatment for MPNST causes a decrease  in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Basil hence should be eaten with Trametinib treatment for this cancer.

Cabbage :  Cabbage contains active ingredients like Benzyl Isothiocyanate, Isorhamnetin, Vitamin C. Intake of Benzyl Isothiocyanate along with Trametinib treatment for MPNST causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cabbage hence should be eaten with Trametinib treatment for this cancer.

Should I take this Nutritional Supplement for Malignant Peripheral Nerve Sheath Tumor?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Trametinib treatment. Black Seed supports the Trametinib treatment for MPNST by decreasing the biochemical pathways called Epithelial to Mesenchymal Transition, MAPK Signaling, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, Angiogenesis, Inositol Phosphate Signaling, TGFB Signaling, C-type Lectin Receptor Signaling, WNT Beta-catenin Signaling, RAS-RAF Signaling.

Which Foods To Avoid for Malignant Peripheral Nerve Sheath Tumor?

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of Malignant Peripheral Nerve Sheath Tumor?

In the initial stages, most cancers including Malignant Peripheral Nerve Sheath Tumor may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by this cancer.

  • A growing lump under the skin
  • Pain in the affected area
  • Weakness 

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Malignant Peripheral Nerve Sheath Tumor.

What are the Treatment Options for Malignant Peripheral Nerve Sheath Tumor?

The treatment for Malignant Peripheral Nerve Sheath Tumor may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:

  • Surgery
  • Chemotherapy
  • Radiation Therapy
  • Rehabilitation to recover function and mobility lost due to nerve damage

Surgery or surgery followed by radiation is used for the treatment of MPNST. Radiotherapy and Chemotherapy help to shrink the tumor. Chemotherapy is also used for the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for this cancer.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Malignant Peripheral Nerve Sheath Tumor.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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