Foods for Angioimmunoblastic T-cell Lymphoma!

Introduction

Foods for Angioimmunoblastic T-cell Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Angioimmunoblastic T-cell Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Angioimmunoblastic T-cell Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Angioimmunoblastic T-cell Lymphoma?

For example does it matter if vegetable Ivy Gourd is consumed more compared to Malabar Spinach? Does it make any difference if fruit Grapefruit is preferred over Bael? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Chickpea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Angioimmunoblastic T-cell Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Angioimmunoblastic T-cell Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Lycopene, Daidzein, Lupeol, Formononetin. And Bael contains active ingredients Vitamin C, Beta-sitosterol, Linolenic Acid, Chlorogenic Acid, Auraptene and possibly others.

A common mistake made when deciding and choosing foods to eat for Angioimmunoblastic T-cell Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Angioimmunoblastic T-cell Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Angioimmunoblastic T-cell Lymphoma?

Personalized nutrition for cancers like Angioimmunoblastic T-cell Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Angioimmunoblastic T-cell Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Angioimmunoblastic T-cell Lymphoma

All cancers like Angioimmunoblastic T-cell Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Angioimmunoblastic T-cell Lymphoma. Biochemical pathways like DNA Repair, Hypoxia, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Angioimmunoblastic T-cell Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Angioimmunoblastic T-cell Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Angioimmunoblastic T-cell Lymphoma when taking cancer treatment Azacitidine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TET2, DNMT3A, IDH2, RHOA and BRAF are the top ranked reported genes for Angioimmunoblastic T-cell Lymphoma. TET2 is reported in 75.0 % of the representative patients across all clinical trials. And DNMT3A is reported in 58.3 %. The combined population patient data cover ages from to . 30.0 % of the patient data are identified as men. The Angioimmunoblastic T-cell Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Angioimmunoblastic T-cell Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable IVY GOURD or MALABAR SPINACH?

Vegetable Ivy Gourd contains many active ingredients or bioactives such as Vitamin C, Beta-sitosterol, Linolenic Acid, Linoleic Acid. These active ingredients manipulate various biochemical pathways like MYC Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia and others. Ivy Gourd is recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine. This is because Ivy Gourd modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Azacitidine.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Apigenin, Curcumin, Lycopene, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair, Notch Signaling and Oncogenic Cancer Epigenetics and others. Malabar Spinach is not recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE IVY GOURD IS RECOMMENDED OVER MALABAR SPINACH FOR Angioimmunoblastic T-cell Lymphoma AND TREATMENT Azacitidine.

Choose Fruit BAEL or GRAPEFRUIT?

Fruit Bael contains many active ingredients or bioactives such as Vitamin C, Beta-sitosterol, Linolenic Acid, Chlorogenic Acid, Auraptene. These active ingredients manipulate various biochemical pathways like Apoptosis, Oncogenic Cancer Epigenetics, Hypoxia and MYC Signaling and others. Bael is recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine. This is because Bael modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Azacitidine.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lycopene, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Notch Signaling and others. Grapefruit is not recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BAEL IS RECOMMENDED OVER GRAPEFRUIT FOR Angioimmunoblastic T-cell Lymphoma AND TREATMENT Azacitidine.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, DNA Repair and Hypoxia and others. Butternut is recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Azacitidine.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended for Angioimmunoblastic T-cell Lymphoma when ongoing cancer treatment is Azacitidine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Angioimmunoblastic T-cell Lymphoma AND TREATMENT Azacitidine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Angioimmunoblastic T-cell Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or SWAMP CABBAGE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Phloretin, Cinnamaldehyde, Geraniol. These active ingredients manipulate various biochemical pathways like Cell Junctions, RAS-RAF Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics and others. Cauliflower is recommended for risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Lycopene, Curcumin, Lupeol, Phloretin, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Cytoskeletal Dynamics and MAPK Signaling and others. Swamp Cabbage is not recommended when risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER SWAMP CABBAGE FOR BRAF GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Curcumin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Junctions, Netrin Signaling, Oncogenic Cancer Epigenetics and Hypoxia and others. Red Raspberry is recommended for risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Lycopene, Curcumin, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Cytoskeletal Dynamics and MYC Signaling and others. Pummelo is not recommended when risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR BRAF GENETIC RISK OF CANCER.

Choose Nut BLACK WALNUT or BRAZIL NUT?

Black Walnut contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Curcumin, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Netrin Signaling, MAPK Signaling and MYC Signaling and others. Black Walnut is recommended for risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Ellagic Acid, Curcumin, Lupeol, Phloretin, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Cell Junctions, RAS-RAF Signaling and Cytoskeletal Dynamics and others. Brazil Nut is not recommended when risk of Angioimmunoblastic T-cell Lymphoma when associated genetic risk is BRAF because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER BRAZIL NUT FOR BRAF GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Angioimmunoblastic T-cell Lymphoma. Angioimmunoblastic T-cell Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Angioimmunoblastic T-cell Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Ivy Gourd contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Angioimmunoblastic T-cell Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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