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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Large Cell Lung Carcinoma?

Apr 20, 2021

Home » Blogs » Which 3 Foods to Avoid for Large Cell Lung Carcinoma?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Large Cell Lung Carcinoma (LCLC) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Allspice and Almond should be eaten when undergoing Cisplatin treatment for Large Cell Lung Carcinoma. On the same lines, foods like Cherry and Common Pea should be avoided with treatment of Cisplatin for Large Cell Lung Carcinoma (LCLC). Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cisplatin treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Large Cell Lung Carcinoma.



What is Large Cell Lung Carcinoma (LCLC)?

Large Cell Lung Carcinoma (LCLC) is a rare non-small cell lung cancer that develops from the epithelial cells of the lung. The incidence rate of this cancer is only 0.8-1.5  per 1 lakh people per year. This cancer is commonly diagnosed in people who are above 60 years of age, however, it can occur in people of any age. It is more commonly found in females as compared to males.

Large Cell Lung Carcinoma (LCLC) - Symptoms, Treatment, Diet, Foods

Large Cell Lung Carcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, SMARCA4, BCORL1, and EPHA3 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in LCLC can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Large Cell Lung Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Large Cell Lung Carcinoma (LCLC) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Large Cell Lung Carcinoma?

In LCLC, activation or inhibition of some of the biochemical pathways including P53 Signaling, Wnt Beta-catenin Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, DNA Repair, MYC Signaling and Oxidative Stress plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Large Cell Lung Carcinoma (LCLC), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Cisplatin treatment for Large Cell Lung Carcinoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Large Cell Lung Carcinoma (LCLC) considering only one specific treatment.

Foods to Avoid

Cherry : Cherry contains active ingredients such as Chlorogenic Acid, Pelargonidin, Quercetin and others. Chlorogenic Acid interferes with the impact of Cisplatin in Large Cell Lung Carcinoma by activating a specific biological process called Oxidative Stress. Hence, do not eat Cherry with Cisplatin treatment for this cancer. (Daniela Catanzaro et al, Nat Prod Commun., 2016; Sakashi Fujimori et al, Int J Oncol., 2004)

Common Pea : Common Pea contains active ingredients such as Citric Acid, Pelargonidin, Vitamin C and others. Citric Acid interferes with the impact of Cisplatin in LCLC by activating a specific biological process called Oxidative Stress. Hence, do not eat Common Pea with Cisplatin treatment for this cancer. (Feng Wang et al, Chem Commun (Camb)., 2013; Sakashi Fujimori et al, Int J Oncol., 2004)

Foods to Eat

Allspice :  Allspice contains active ingredients like Salicylic Acid, Eucalyptol and Gallic Acid. Intake of Salicylic Acid along with Cisplatin treatment for Large Cell Lung Carcinoma causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Allspice hence should be eaten with Cisplatin treatment for this cancer. (Anna Bratasz et al, Proc Natl Acad Sci U S A., 2006; Zhen Zhou et al, Thorac Cancer., 2019; Lei Duan et al, Cancer Biol Ther., 2014)

Almond :  Almond contains active ingredients like Salicylic Acid, Quercetin and Vitamin E. Intake of Salicylic Acid along with Cisplatin treatment for LCLC causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Cisplatin treatment for this cancer. (Anna Bratasz et al, Proc Natl Acad Sci U S A., 2006; Zhen Zhou et al, Thorac Cancer., 2019; Lei Duan et al, Cancer Biol Ther., 2014)

Should I take this Nutritional Supplement for Large Cell Lung Carcinoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cisplatin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in LCLC. Hence, avoid taking Black seed supplements with Cisplatin treatment in this Cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)

Which Foods To Avoid for Large Cell Lung Carcinoma?

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of Large Cell Lung Carcinoma?

In the initial stages, most cancers including Large Cell Lung Carcinoma may not cause any signs or symptoms. However, as the disease progresses, Large Cell Lung Carcinoma may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by this cancer.

  • Coughing up blood
  • Persistent cough
  • Hoarseness in voice
  • Chest pain
  • Shortness of breath
  • Fatigue
  • Unexplained weight loss
  • Loss of appetite

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Large Cell Lung Carcinoma.

What are the Treatment Options for Large Cell Lung Carcinoma?

The treatment for Large Cell Lung Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history. The treatment options for this cancer include:

  • Surgery
  • Chemotherapy
  • Radiation therapy
  • Targeted therapy
  • Immunotherapy

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Large Cell Lung Carcinoma (LCLC).

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Large Cell Lung Carcinoma (LCLC).

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

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