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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Anorectal Mucosal Melanoma?

Apr 14, 2021

Home » Blogs » Which 3 Foods to Avoid for Anorectal Mucosal Melanoma?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anorectal Mucosal Melanoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Bamboo and Barley should be eaten when undergoing Belinostat treatment for Anorectal Mucosal Melanoma. On the other hand, for this cancer, Arugula and Bitter Melon should be eaten with treatment of Carmustine. On the same lines, foods like Amaranth and Cauliflower should be avoided with treatment of Belinostat for Anorectal Mucosal Melanoma. If the treatment is Carmustine, then avoid Beetroot and Bell Pepper.

Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Carmustine treatment and hence should be avoided. However, Black seed supplements have no known CYP interactions with Belinostat.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anorectal Mucosal Melanoma.



What is Anorectal Mucosal Melanoma?

Melanoma is a type of cancer that develops from the cells which provides color to the skin called melanocytes. Anorectal Mucosal Melanoma is a rare type of melanoma that develops in the anus or rectum. The incidence rate of this cancer is only 0.46 per 1 lakh people per year in the United States. This cancer is commonly diagnosed in people who are over 60 years of age, however, it can occur in people of any age. It is more commonly found in female Asian/Pacific Islanders, as compared to other ethnic groups.

Anorectal Mucosal Melanoma - Symptoms, treatment, diet, foods

Anorectal Mucosal Melanoma has prevalence of certain genetic changes. Some of the genes such as SF3B1, KIT, NF1, and NRAS are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Anorectal Mucosal Melanoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Anorectal Mucosal Melanoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Anorectal Mucosal Melanoma?

In Anorectal Mucosal Melanoma, activation or inhibition of some of the biochemical pathways including Oxidative Stress, Apoptosis, Cell Cycle, MAPK Signaling, P53 Signaling, Cell Cycle Checkpoints, DNA Repair, RAS-RAF Signaling, MYC Signaling, Wnt Beta-Catenin Signaling, Cancer Epigenetics, Epithelial To Mesenchymal Transition and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anorectal Mucosal Melanoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Belinostat treatment for Anorectal Mucosal Melanoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Anorectal Mucosal Melanoma considering only the treatment changes.

Foods to Avoid

Amaranth : Amaranth contains active ingredients such as Citric Acid, Folic Acid, Oleic Acid and others. Citric Acid interferes with the impact of Belinostat in Anorectal Mucosal Melanoma by blocking a specific biological process called Oxidative Stress. Hence, do not eat Amaranth with Belinostat treatment for this Cancer.

Cauliflower : Cauliflower contains active ingredients such as Brassinin, Folic Acid, Oleic Acid and others. Brassinin interferes with the impact of Belinostat in Anorectal Mucosal Melanoma by blocking a specific biological process called Oxidative Stress. Hence, do not eat Cauliflower with Belinostat treatment for this Cancer.

Foods to Eat

Bamboo :  Bamboo contains active ingredients like Vitamin C, Oleic Acid and Linolenic Acid. Intake of Vitamin C along with Belinostat treatment for Anorectal Mucosal Melanoma causes a decrease  in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect.  Bamboo hence should be eaten with Belinostat treatment for this Cancer.

Barley :  Barley contains active ingredients like Vitamin C, Folic Acid and Oleic Acid. AS mentioned above, the Intake of Vitamin C along with Belinostat treatment for Anorectal Mucosal Melanoma causes a decrease  in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect.  Barley hence should be eaten with Belinostat treatment for this Cancer.

Should I take this Nutritional Supplement for Anorectal Mucosal Melanoma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Belinostat treatment. Black Seed supports the Belinostat treatment for Anorectal Mucosal Melanoma by decreasing the biochemical pathways/processes like MAPK Signaling, JAK-STAT Signaling, Cell Cycle, MYC Signaling, PI3K-AKT-MTOR Signaling, C-type Lectin Receptor Signaling and RAS-RAF Signaling, and increasing pathways like Cell Cycle Checkpoints, Oxidative Stress. Hence, Black seed supplements may be taken along with Belinostat treatment for this cancer.

Example Foods to “Not Eat” and Eat with Carmustine treatment for Anorectal Mucosal Melanoma

Foods to Avoid

Beetroot : Beetroot contains active ingredients such as Beta-sitosterol, Folic Acid and Oleic Acid and others. Beta-sitosterol interferes with the impact of Carmustine in Anorectal Mucosal Melanoma by blocking a specific biological process called Cancer Epigenetics. Hence, do not eat Beetroot with Carmustine treatment for this cancer.

Bell Pepper : Bell Pepper contains active ingredients such as Capsaicin, Folic Acid, Isorhamnetin and others. Capsaicin interferes with the impact of Carmustine in Anorectal Mucosal Melanoma by activating a specific biochemical pathway called MYC Signaling. Hence, do not eat Bell Pepper with Carmustine treatment for this cancer.

Foods to Eat

Arugula :  Arugula contains active ingredients like Esculin, Retinol, Erysolin. Intake of Esculin along with Carmustine treatment for Anorectal Mucosal Melanoma causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Arugula hence should be eaten with Carmustine treatment for this Cancer.

Bitter Melon :  Bitter Melon contains active ingredients like Cucurbitacin E, Oleic Acid, Linolenic Acid. Intake of Cucurbitacin E along with Carmustine treatment for Anorectal Mucosal Melanoma causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bitter Melon hence should be eaten with Carmustine treatment for this Cancer.

Should I take this Nutritional Supplement for Anorectal Mucosal Melanoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Carmustine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Carmustine treatment efficacy in Anorectal Mucosal Melanoma. Hence, avoid taking Black seed supplements with Carmustine treatment for this cancer.

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Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of this Cancer?

In the initial stages, most cancers including Anorectal Mucosal Melanoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Anorectal Mucosal Melanoma.

  • Swelling or a lump in the rectum (back passage)
  • Rectal bleeding 
  • Rectal pain 
  • Itching in back passage
  • Change in bowel habits
  • Affected area may be pigmented 

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anorectal Mucosal Melanoma.

What are the Treatment Options for this Cancer?

The treatment for Anorectal Mucosal Melanoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:

  • Surgery
  • Radiotherapy
  • Chemotherapy
  • Targeted Therapy
  • Immunotherapy

Surgery or surgery followed by radiation is the most common treatment regimen for Anorectal Mucosal Melanoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Anorectal Mucosal Melanoma.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anorectal Mucosal Melanoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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