No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Angiosarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Barley and Blackberry should be eaten when undergoing Vincristine treatment for Angiosarcoma. On the other hand, for Angiosarcoma, Almond and Beetroot should be eaten with treatment of Cyclophosphamide. On the same lines, avoid foods like Buttermilk and Lard with treatment of Vincristine for Angiosarcoma. If the treatment is Cyclophosphamide, then Angiosarcoma patients should avoid foods like Cherry and Chicory.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Vincristine and Cyclophosphamide treatments and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Angiosarcoma.
What is Angiosarcoma?
Angiosarcoma is a rare type of soft tissue sarcoma that develops in blood or lymph vessels. The incidence rate of this cancer is only 0.21 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 65 years of age, however, it can occur in people of any age. It is more commonly found in White population as compared to Black population. (Chao Zhang et al, Jpn J Clin Oncol., 2019)
Angiosarcoma has prevalence of certain genetic changes. Some of the genes such as TP53, MAP3K9, PTPN1, and COL7A1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Angiosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Angiosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Angiosarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Angiosarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Angiosarcoma?
In Angiosarcoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, Hypoxia, Epithelial To Mesenchymal Transition, DNA Repair, P53 Signaling and Cell Cycle plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Angiosarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Vincristine treatment for Angiosarcoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Angiosarcoma considering only the treatment changes.
Foods to Avoid with Vincristine treatment
Buttermilk : Buttermilk contains active ingredients such as Lauric Acid, Vitamin D3, Myristic Acid and others. Lauric Acid interferes with the impact of Vincristine in Angiosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Buttermilk with Vincristine treatment for Angiosarcoma. (Ronald P Mensink et al, m J Clin Nutr., 2003; D M Rocha et al, Atherosclerosis., 2016; Rosamaria Lappano et al, Cell Death Discov., 2017; Yingying Meng et al, J Agric Food Chem., 2017; Xia Xie et al, Oncol Rep., 2013; Antoine Italiano et al, Cancer., 2012; M E Weidema et al, Crit Rev Oncol Hematol., 2019)
Lard : Lard contains active ingredients such as Myristic Acid, Palmitic Acid and others. Myristic Acid interferes with the impact of Vincristine in Angiosarcoma by activating a specific biological process called Cell Cycle. Hence, avoid foods like Lard with Vincristine treatment for Angiosarcoma. (Li Zeng et al, PLoS One., 2008; H Mujagic et al, Cancer Res., 1983; M E Weidema et al, Crit Rev Oncol Hematol., 2019)
Foods to Eat with Vincristine treatment
Barley : Barley contains active ingredients like Beta-sitosterol, Oleic Acid and Folic Acid. Intake of Beta-sitosterol along with Vincristine treatment for Angiosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Barley hence should be eaten with Vincristine treatment for Angiosarcoma. (Song Hyo Sook et al, Phytother Res., 2014; Zhang-Qi Cao et al, Front Pharmacol., 2020; David J Vanderweele et al, Mol Cancer Res., 2005; Antoine Italiano et al, Cancer., 2012; M E Weidema et al, Crit Rev Oncol Hematol., 2019)
Blackberry : Blackberry contains active ingredients like Hyperoside, Myricetin and Gallic Acid. Intake of Hyperoside along with Vincristine treatment for Angiosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Blackberry hence should be eaten with Vincristine treatment for Angiosarcoma. (Yinghui Kong et al, Front Biosci (Landmark Ed)., 2020; Li-Min Wang et al, Clin Lab., 2018; David J Vanderweele et al, Mol Cancer Res., 2005; Antoine Italiano et al, Cancer., 2012; M E Weidema et al, Crit Rev Oncol Hematol., 2019)
Should I take this Nutritional Supplement with Vincristine treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vincristine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Vincristine treatment efficacy in Angiosarcoma. Hence, do not take Black seed supplements with Vincristine treatment for Angiosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Marija Bosilkovska et al, Clin Ther., 2016; M E Weidema et al, Crit Rev Oncol Hematol., 2019)
Example Foods to “Not Eat” and Eat with Cyclophosphamide treatment for Angiosarcoma
Foods to Avoid with Cyclophosphamide treatment
Cherry : Cherry contains active ingredients such as Chrysin, Salicylic Acid, Genistein and others. Chrysin interferes with the impact of Cyclophosphamide in Angiosarcoma by activating a specific biological process called Epithelial to Mesenchymal Transition. Hence, avoid foods like Cherry with Cyclophosphamide treatment for Angiosarcoma. (Heshu Lu et al, J Med Chem., 2005; Won Kyu Kim et al, Scientific Reports, 2019; Ai-Mei Gao et al, Chem Biol Interact., 2013; In-Geun Ryoo et al, PLoS One., 2014; Jing Wang et al, Genes Dis., 2016; Justine Daguzé et al, JAAD Case Rep., 2016)
Chicory : Chicory contains active ingredients such as Apigenin, Salicylic Acid, Gallic Acid and others. Apigenin interferes with the impact of Cyclophosphamide in Angiosarcoma by activating a specific biological process called DNA Repair. Hence, avoid foods like Chicory with Cyclophosphamide treatment for Angiosarcoma. (Sreemanti Das et al, J Acupunct Meridian Stud., 2013; Haripaul Sharma et al, PLoS One., 2014; Justine Daguzé et al, JAAD Case Rep., 2016)
Foods to Eat with Cyclophosphamide treatment
Almond and Beetroot: Almond and Beetroot contain active ingredients like Vitamin E, Salicylic Acid and Oleic Acid. Intake of Vitamin E along with Cyclophosphamide treatment for Angiosarcoma causes a decrease in a specific biochemical pathway which is called DNA Repair, and this is a very positive effect. Almond and Beetroot hence should be eaten with Cyclophosphamide treatment for Angiosarcoma. (Gokhan Cuce et al, Chem Biol Interact., 2015; Sukta Das, Aclo Uncologicr., 1994; Justine Daguzé et al, JAAD Case Rep., 2016)
Should I take this Nutritional Supplement with Cyclophosphamide treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 and CYP2C9 interactions with Cyclophosphamide treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cyclophosphamide treatment efficacy in Angiosarcoma. Hence, do not take Black seed supplements with Cyclophosphamide treatment for Angiosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Priya P Gor et al, Breast Cancer Res., 2010; Justine Daguzé et al, JAAD Case Rep., 2016)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Angiosarcoma?
In the initial stages, most cancers including Angiosarcoma may not cause any signs or symptoms. However, as the disease progresses, Angiosarcoma may start showing symptoms, which depends on the location.
Following are some of the signs and symptoms that may be caused by Angiosarcoma.
- Bruise-like lesions that grow over time
- Violet/Purplish raised soft lump
- Sore that continues to grow
- Lesion that bleeds when bumped or scratched
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Angiosarcoma.
What are the Treatment Options for Angiosarcoma?
The treatment for Angiosarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Angiosarcoma include:
- Radiation Therapy
Surgery or surgery followed by radiation is the most common treatment regimen for Angiosarcoma. Radiotherapy helps to shrink the tumor and is used when the tumor cannot not be removed by surgery. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Angiosarcoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Angiosarcoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.