No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Systemic mastocytosis needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Basil and Broccoli should be eaten when undergoing Midostaurin treatment for Systemic mastocytosis. On the same lines, avoid foods like Bell Pepper and Green Bean with treatment of Midostaurin for Systemic mastocytosis.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Midostaurin treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for diseases like Systemic mastocytosis.
What is Systemic mastocytosis?
Systemic mastocytosis is a rare blood disorder that results in abnormal increase in mast cells in body tissues and organs, such as the skin, liver, spleen, bone marrow, small intestine and bones. The incidence rate of this disease is only 0.5-1 per 1 lakh people per year. This disease is commonly diagnosed in people who are about 55 years of age, however, it can occur in people of any age. It affects men and women equally. Systemic mastocytosis may become cancerous. The risk of this condition becoming cancerous is 7% in children and up to 30% in adults.
Systemic mastocytosis has prevalence of certain genetic changes. Some of the genes such as KIT, TET2, JAK2, and RUNX1 are known to have genetic abnormalities in this disease resulting in a change of function.
The genetic abnormalities found in Systemic mastocytosis can influence specific biochemical pathways to drive these disease cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Systemic mastocytosis. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Systemic mastocytosis genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or disease diagnosis – it may impact the nutrition and the nutrition/diet plan for Systemic mastocytosis nutrition may have to be redesigned.
Why Eating Right Matters for Systemic mastocytosis?
In Systemic mastocytosis, activation or inhibition of some of the biochemical pathways including Hypoxia, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling, MAPK Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Systemic mastocytosis, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the disease progression.
Example Foods to “Not Eat” and Eat with Midostaurin treatment for Systemic mastocytosis
The nutrition for this condition depends on the type, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Systemic mastocytosis considering only one specific treatment- Midostaurin.
Foods to Avoid with Midostaurin treatment
Bell Pepper : Bell Pepper contains active ingredients such as Capsaicin, Retinol, Folic Acid and others. Capsaicin interferes with the impact of Midostaurin in Systemic mastocytosis by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Bell Pepper with Midostaurin treatment for Systemic mastocytosis. (Mun Kyung Hwang et al, Cancer Res., 2010; Molly M Gallogly et al, Ther Adv Hematol., 2017)
Green Bean : Green Bean contains active ingredients such as Folic Acid, Astragalin, Ferulic Acid and others. Folic Acid interferes with the impact of Midostaurin in Systemic mastocytosis by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, do not eat Green Bean with Midostaurin treatment for this condition. (Jing Zhang et al, Int J Clin Exp Med., 2019; D J DeAngelo et al, Leukemia., 2018; Molly M Gallogly et al, Ther Adv Hematol., 2017)
Foods to Eat with Midostaurin treatment
Basil : Basil contains active ingredients like D-limonene, Esculin, Beta-sitosterol. Intake of D-limonene along with Midostaurin treatment for Systemic mastocytosis causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Basil hence should be eaten with Midostaurin treatment for this condition. (X Chen et al, Chin Med Sci J., 1999; Molly M Gallogly et al, Ther Adv Hematol., 2017)
Broccoli : Broccoli contains active ingredients like Sulforaphane, Ferulic Acid, Folic Acid. Intake of Sulforaphane along with Midostaurin treatment for Systemic mastocytosis causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Broccoli hence should be eaten with Midostaurin treatment for this condition. (Young-Sam Keum et al, Cancer Res., 2006; Molly M Gallogly et al, Ther Adv Hematol., 2017)
Should I take this Nutritional Supplement with Midostaurin treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Midostaurin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Midostaurin treatment efficacy in Systemic mastocytosis. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Catherine Dutreix et al, Cancer Chemother Pharmacol., 2013)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Systemic mastocytosis?
As the disease progresses, Systemic mastocytosis may start showing symptoms. The signs and symptoms of systemic mastocytosis may depend on the part of the body affected by an abnormally high number of mast cells.
Following are some of the signs and symptoms that may be caused by this condition.
- Bleeding disorders
- Stomach pain, diarrhea, nausea, vomiting
- Enlarged liver, spleen or lymph nodes
- Anaphylactic shock
- Flushing, Itching or hives of the skin
- Bone pain
- Muscle pain
- Mood changes/ Depression
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Systemic mastocytosis.
What are the Treatment Options for this condition?
The treatment for Systemic mastocytosis may be decided based on symptoms, disease characteristics, patient’s general health and medical history. The treatment options for Systemic mastocytosis include:
- Medications like antihistamines, mast cell stabilizers, corticosteroids to handle specific symptoms
- Stem cell transplant
Chemotherapy is often recommended if mastocytosis becomes cancerous. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Systemic mastocytosis.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing diseases such as Systemic mastocytosis.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.