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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

Which 3 Foods to Avoid for Leiomyosarcoma?

Mar 9, 2021

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Leiomyosarcoma needs to be personalized to minimize adverse interactions between nutrition/foods/diet and treatment, and to improve symptoms.

Foods like Jicama and Wild Leek should be eaten when undergoing Cisplatin treatment for Leiomyosarcoma. On the other hand, for Leiomyosarcoma, Almond and Gram Bean should be eaten with treatment of Fluorouracil. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Cisplatin for Leiomyosarcoma. If the treatment is Fluorouracil, then avoid Margarine and Cucumber.
Blackseed nutritional supplement contains an active ingredient called thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cisplatin and Fluorouracil treatments and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Leiomyosarcoma.



What is Leiomyosarcoma?

Leiomyosarcoma is a rare cancer and a soft tissue sarcoma that develops from the smooth muscle cells. The incidence rate of this cancer is only 1.23 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 52 years of age, however, it can occur in people of any age. It is more commonly found in African Americans as compared to Caucasians.

Symptoms, Treatment and Diet for Leiomyosarcoma

Leiomyosarcoma has prevalence of certain genetic changes. Some of the genes such as TP53, TMEM30A, DDX3X, and CSMD3 are known to have genetic abnormalities in this cancer resulting in a change of function.

The genetic abnormalities found in Leiomyosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Leiomyosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Leiomyosarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Leiomyosarcoma nutrition may have to be redesigned. 

Why Eating Right Matters for Leiomyosarcoma?

In Leiomyosarcoma, activation or inhibition of some of the biochemical pathways including Oxidative Stress, PI3K-AKT-MTOR Signaling, MAPK Signaling, NFKB Signaling and Cell Cycle Checkpoints plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Leiomyosarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Cisplatin treatment for Leiomyosarcoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here, we show changes in nutrition/diet for leiomyosarcoma considering only the treatment changes.

Foods to Avoid

Amaranth and Beetroot : Amaranth and Beetroot contain active ingredients such as Citric Acid, Oleic Acid, and others. Citric Acid interferes with the impact of Cisplatin in Leiomyosarcoma by blocking a biological process called oxidative stress. Oxidative stress causes apoptosis or cell death in different types of cancers. Hence do not eat Amaranth and Beetroot with Cisplatin treatment for Leiomyosarcoma. (Juhee Lim et al, Mol Cells., 2013; Omar M E Abdel-Salam et al, J Med Food., 2014; J T Thigpen et al, J Clin Oncol., 1991)

Foods to Eat

Jicama and Wild Leek : Jicama and Wild Leek contain active ingredients like Vitamin C, Retinol and Folic Acid. Intake of Vitamin C along with Cisplatin treatment for Leiomyosarcoma causes a decrease in a specific biochemical pathway which is called  PI3K-AKT-MTOR, and this is a very positive effect. Jicama and Wild Leek hence should be eaten with Cisplatin treatment for Leiomyosarcoma. Experimental study has also shown that Vitamin C has the potential to reduce the risk of soft tissue sarcomas. (A M Abdel-Galil et al, Oncology., 1986; Benjamin Fourneaux et al, Oncotarget., 2017; Tine Cuppens et al, Clin Cancer Res., 2017; Xi Su et al, Theranostics., 2019; Xianfu Wei et al, Am J Transl Res., 2020; J T Thigpen et al, J Clin Oncol., 1991)

Should I take this Nutritional Supplement for Leiomyosarcoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as thymoquinone which have CYP2B6 and CYP3A4 interactions with Cisplatin treatment, and hence should not be used. Also black seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in Leiomyosarcoma. (Pius S Fasinu et al, Front Oncol., 2019; Vlastimil Masek et al, Anticancer Drugs., 2009; Ahmed A Albassam et al, Saudi Pharm J., 2018; J T Thigpen et al, J Clin Oncol., 1991)

Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Leiomyosarcoma

Foods to Avoid

Margarine : Margarine contains active ingredients such as Lauric Acid, Myristic Acid, Vitamin D3 and others. Saturated fatty acids like Lauric Acid interfere with the impact of Fluorouracil in Leiomyosarcoma by activating biochemical pathways called PI3K-AKT-MTOR and MAPK. Hence, do not eat Margarine with Fluorouracil treatment for Leiomyosarcoma.(Joo Y Lee et al, J Biol Chem., 2003; Jae Hoon Moon et al, Lipids., 2010; Benjamin Fourneaux et al, Oncotarget., 2017; Eun-Ji Kim et al, Oncotarget., 2018)

Cucumber : Cucumber contains active ingredients such as Cucurbitacin I, Oleic Acid, Salicylic Acid and others. Cucurbitacin I interferes with the impact of Fluorouracil in Leiomyosarcoma by activating biochemical pathways called NFKB and MAPK. Hence, do not eat Cucumber Fluorouracil treatment for Leiomyosarcoma. (Yao Wu et al, Toxicol Lett., 2016; Braden C McFarland et al, Mol Cancer Res., 2013; Rene Voboril et al, J Surg Res., 2004; Eun-Ji Kim et al, Oncotarget., 2018)

Foods to Eat

Almond : Almond contains active ingredients like Salicylic Acid, Oleic Acid and Vitamin E. Intake of Salicylic Acid with Fluorouracil treatment for Leiomyosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR, and this is a very positive effect. Almond hence should be eaten with Fluorouracil treatment for Leiomyosarcoma. (Benjamin Fourneaux et al, Oncotarget., 2017; Simon A Hawley et al, Science., 2012; Whitney S Henry et al, Cancer Res., 2017; Xiaoyue Zhang et al, Oncol Rep., 2013; Fu et al, Sci Rep., 2019; Eun-Ji Kim et al, Oncotarget., 2018)

Gram Bean : Gram Bean contains active ingredients like Vitamin C, Oleic Acid and Folic Acid. Intake of Vitamin C with Fluorouracil treatment for Leiomyosarcoma causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR, and this is a very positive effect. Gram Bean hence should be eaten with Fluorouracil treatment for Leiomyosarcoma.(A M Abdel-Galil et al, Oncology., 1986; Benjamin Fourneaux et al, Oncotarget., 2017; Xi Su et al, Theranostics., 2019; Eun-Ji Kim et al, Oncotarget., 2018; Beatrix Nagy et al, In Vivo., May-Jun 2003)

Should I take this Nutritional Supplement for Leiomyosarcoma?

Black Seed : Black Seed supplements contain active ingredients such as thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also black seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Leiomyosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; T Komatsu et al, Drug Metab Dispos., 2000)

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of Leiomyosarcoma?

In the initial stages, most cancers including Leiomyosarcoma may not cause any signs or symptoms. However, as the disease progresses, Leiomyosarcoma may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Leiomyosarcoma.

  • Bloating in the abdomen
  • Unusual swelling in different areas in the body or lumps under the skin
  • Pain
  • Fatigue
  • Weight Loss
  • A change in menstruation
  • Breathing difficulties
  • Fever
  • Frequent urination
  • Black-colored stools
  • Vomiting blood

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Leiomyosarcoma.

What are the Treatment Options for this Cancer?

The treatment for Leiomyosarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Leiomyosarcoma include:

  • Surgery
  • Radiotherapy
  • Chemotherapy
  • Targeted Therapy

Surgery or surgery followed by radiation is the most common treatment regimen for Leiomyosarcoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Leiomyosarcoma.

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In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Leiomyosarcoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.