Imuphi umdlavuza ongahlomula ngokufaka i-Vitamin E ekudleni kwabo?

Amaphuzu avelele

I-Vitamin E yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Vitamin E ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, uVithamini E angase azuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Fluorouracil ye-Primary Pediatric Hepatoblastoma. Ngaphezu kwalokho, nakuba i-Vitamin E ingasiza abantu abane-genetic risk factor "ERBB2", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Vitamin E esigulini somdlavuza kudinga umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi uVithamini E uyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izakhi ezisebenzayo ekudleni/izithasiselo ezifana ne-Vitamin E esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Vitamin E ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle u-Vitamin E uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ERBB2? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Vitamin E ekudleni kwakho uma kutholakala ukuthi une-Primary Pediatric Hepatoblastoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho u-Vitamin E kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye ku-Fluorouracil? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'UVitamin E ungokwemvelo, ngakho uhlezi ezuzisa' noma 'uVithamini E uqinisa ukuzivikela komzimba' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Vitamin E ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Vitamin E ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Pediatric Hepatoblastoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufakwe engcupheni yezakhi zofuzo kanye nokuxilonga umdlavuza othize lapho unquma ukukhetha ukudla, okufana no-Vitamin E. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguquka kwezakhi zofuzo ku-ERBB2 inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwesinye isakhi sofuzo? ? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary Pediatric Hepatoblastoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Fluorouracil njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Vitamin E - Isengezo Esinomsoco

Isithasiselo se-Vitamin E sihlanganisa uhla lwezithako ezisebenzayo, kufaka phakathi i-Vitamin E, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi Ukulungiswa Kwe-DNA, I-Oxidative Stress kanye ne-Cell Cycle Checkpoints, elawula izici ezibalulekile zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Vitamin E, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Vitamin E yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Vitamin E akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa komuntu siqu.

Ukukhetha Vitamin E Izithako

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiwugweme u-Vitamin E esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Vitamin E kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Vitamin E ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe Izithasiselo Ze-Vitamin E zizozizuzisa Iziguli Eziyisisekelo Ze-Hepatoblastoma Ezelashwa nge-Fluorouracil?

I-Hepatoblastoma Yezingane Eyisisekelo ibonakala ngokushintsha kofuzo okuthile, okuyi-CTNNB1, HUWE1 kanye ne-NFE2L2, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Adherens junction, i-Androgen Signaling, i-Oxidative Stress kanye Nezindawo Zokuhlola Amasosha omzimba. Ukusebenza kokwelashwa komdlavuza, okufana ne-Fluorouracil, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Vitamin E, esithinta i-Oxidative Stress, kungenzeka kungabi yisinqumo esifanele esimweni se-Primary Pediatric Hepatoblastoma lapho bethola i-Fluorouracil. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo zikaVithamini E zizozizuzisa Iziguli Eziyinhloko ze-Penile Squamous Cell Carcinoma ezelashwa nge-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi Ukulungiswa kwe-DNA, i-Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo sika-Vitamin E siyindlela enengqondo kulabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Vitamin E ithonya izindlela ezifana nokulungiswa kwe-DNA, okungavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma kuzuzise ukusebenza kahle kwe-Mitomycin.

4. Ingabe Izithasiselo Ze-Vitamin E Ziphephile Kubantu Abanempilo Enempilo Ene-ERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ERBB2 kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa Izindawo Zokuhlola I-Cell Cycle, I-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula ukuguqulwa kwezakhi zofuzo ku-ERBB2 ehambisana ne-Esophageal Adenocarcinoma, cabanga ukufaka izithako ze-Vitamin E ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle Checkpoints, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-ERBB2 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Vitamin E, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-Gamma- ne-delta-tocotrienols inomphumela onamandla wokulwa nomdlavuza kune-alpha-tocopheryl succinate emigqeni yamaseli omdlavuza webele ngokunganaki isisho se-HER-2/neu.
• Umphumela ovimbelayo we-tocotrienol ku-eukaryotic DNA polymerase lambda kanye ne-angiogenesis.
• cBioPortal for Cancer Genomics
• I-Palm tocotrienol yenza imisebenzi engcono yokulwa ne-antioxidant emathanjeni kune-alpha-tocopherol.
• Umphumela wokushiyeka kokulungisa i-DNA ku-cytotoxicity yezidakamizwa ezisetshenziswa ekwelapheni umdlavuza - isibuyekezo.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• [Izifo ezingapheli zokuvuvukala emathunjini. Ukubonakaliswa kwangaphandle kwamathumbu kanye nezinkinga ze-perianal].
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.