Imuphi umdlavuza ongazuza ngokufaka i-Soy Bean ekudleni kwabo?

Amaphuzu avelele

I-Soy Bean yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Soy Bean ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Soy Bean ingase izuze labo abane-Primary Solitary Fibrous Tumor abathola i-Avastin, kodwa kungase kungabi kuhle ezigulini ezithola i-Cisplatin ye-Primary Head kanye ne-Neck Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba i-Soy Bean ingasiza abantu abane-genetic risk factor "CREBBP", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ERCC2". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Soy Bean esigulini esinomdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Soy Bean iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Soy Bean esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Soy Bean ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Soy Bean uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-CREBBP? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-ERCC2? Ingabe kunenzuzo ukufaka i-Soy Bean ekudleni kwakho uma kutholakala ukuthi une-Primary Head and Neck Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ukusebenzisa kwakho i-Soy Bean kufanele kulungiswe kanjani uma welashwa nge-Avastin noma uma uhlelo lwakho lokwelapha lusuka ku-Avastin luye e-Cisplatin? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Soy Bean ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Soy Bean ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Soy Bean ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Soy Bean ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Solitary Fibrous Tumor noma i-Primary Head and Neck Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka kanye ubulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokudla okukhethwa kukho, njengobhontshisi weSoy. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-CREBBP inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ERCC2? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Solitary Fibrous Tumor ilingana ne-Primary Head and Neck Squamous Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Cisplatin njengalabo abathola i-Avastin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Ubhontshisi Wesoya - Isengezo Esinomsoco

Isithasiselo se-Soy Bean sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Vitamin K, i-Lecithin, i-Palmitic Acid, i-Aescin ne-D-glucose, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, Oxidative Stress, Angiogenesis kanye ne-TGFB Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele ezifana ne-Soy Bean, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucubungula ukusebenzisa ubhontshisi weSoy kumdlavuza, kubalulekile ukuthi ucabangele lezi zici nezindlela ezahlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Soy Bean akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako Zobhontshisi Wesoya

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Soy Bean esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Soy Bean kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Soy Bean ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe Izithako Zobhontshisi Wesoya zizozuzisa Iziguli Eziyinhloko Nentamo I-Squamous Cell Carcinoma ezelashwa nge-Cisplatin?

I-Primary Head and Neck Squamous Cell Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-FRG1BP, TP53 ne-PCDH11X, okuholela ekuguqulweni kwezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi Ukucindezeleka Kwe-Oxidative, Izindawo Zokuhlola I-Cell Cycle kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, okufana ne-Cisplatin, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Soy Bean, esithinta i-Oxidative Stress, kungase kungabi inketho efanele esimweni se-Primary Head kanye ne-Neck Squamous Cell Carcinoma lapho uphathwa i-Cisplatin. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Zobhontshisi Wesoya zizozizuzisa Iziguli Eziyinhloko Zodwa Ezine-Fibrous Tumor ezilashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-BRD4, FLI1 kanye ne-KMT2C, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Avastin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Soy Bean siyindlela enengqondo yalabo abane-Primary Solitary Fibrous Tumor ababhekana ne-Avastin. Lokhu kungenxa yokuthi i-Soy Bean ithonya izindlela ezifana ne-MYC Signaling, engavimbela izici ezishayela i-Primary Solitary Fibrous Tumor noma izuzise ukusebenza kwe-Avastin.

3. Ingabe Izithako Zobhontshisi Wesoya Ziphephile Kubantu Abanempilo Enempilo Nge-ERCC2 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ERCC2 luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ubungozi bomdlavuza.

Ukuguqulwa kofuzo lwe-ERCC2 kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana ne-Angiogenesis kanye ne-DNA Repair, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba uguquko ku-ERCC2 oluhlobene nengozi eyengeziwe Yomdlavuza Wesikhumba, ukucabanga okungokwesayensi kuphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Soy Bean. Lokhu kungenxa yokuthi isengezo se-Soy Bean sithonya izindlela ezifana ne-Angiogenesis, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ERCC2 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithako Zobhontshisi Wesoya Ziphephile Kubantu Abanempilo Ene-CREBBP Mutation Associated Genetic Risk?

I-CREBBP idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CREBBP kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-TGFB Signaling kanye ne-Histone/Protein Acetylation, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula uguquko ku-CREBBP ehambisana ne-Follicular Lymphoma, cabanga ukufaka izithasiselo zeSoy Bean ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-TGFB Signaling, zizuze ngokuhlinzeka ngosekelo olufanele kubantu abanokuguqulwa kwe-CREBBP kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Soy Bean, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Ama-subunits we-glutamate cysteine ​​​​ligase athuthukisa ukumelana ne-cisplatin ku-xenografts yomdlavuza wamaphaphu womuntu ongewona omncane weseli ku-vivo.
• cBioPortal for Cancer Genomics
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.