Yimuphi umdlavuza ongazuza ngokufaka iSesamin ekudleni kwabo?

Amaphuzu avelele

I-Sesamin yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweSesamin ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Sesamin ingase izuze labo abane-Primary Glioblastoma abathola i-Temozolomide, kodwa ingase ingabi yinhle ezigulini ezithola i-Dacarbazine ye-Primary Pulmonary artery intimal sarcoma. Ngaphezu kwalokho, nakuba i-Sesamin ingasiza abantu abanesici sengozi yofuzo “ALK”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile ethi “ERCC2”. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kweSesamin esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Sesamin iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo zokudla/izithasiselo ezifana neSesamin esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake iSesamin ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle iSesamin uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ALK? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-ERCC2? Ingabe kunenzuzo ukufaka iSesamin ekudleni kwakho uma kutholakala ukuthi une-Primary Pulmonary artery intimal sarcoma, noma uma ukuxilongwa kwakho kuyi-Primary Glioblastoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Sesamin kufanele kulungiswe kanjani uma welashwa nge-Temozolomide noma uma uhlelo lwakho lokwelapha lusuka ku-Temozolomide luye e-Dacarbazine? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'iSesamin ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Sesamin ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Sesamin ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana neSesamin ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma sekutholakele ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Glioblastoma noma i-Primary Pulmonary artery intimal sarcoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeSesamin. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-ALK inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ERCC2? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Glioblastoma bulingana ne-Primary Pulmonary artery intimal sarcoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kufana nalabo abathola i-Dacarbazine njengalabo abathola i-Temozolomide? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Sesamin - Isengezo Somsoco

Isithasiselo seSesamin sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa iSesamin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-JAK-STAT Signaling, Cell Cycle Checkpoints kanye ne-MAPK Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengeSesamin, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa iSesamin yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweSesamin akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako zeSesamin

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Sesamin esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Sesamin ziyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Sesamin ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo ze-Sesamin zizosizakala Iziguli ezithola ukwelashwa kwe-Dacarbazine okuyisisekelo?

I-Primary Pulmonary artery intimal sarcoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-PDGFRB, ALK kanye ne-ATM, okuholela ekuguqulweni kwezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-MAPK Signaling, Growth Factor Signaling, JAK-STAT Signaling, DNA Repair kanye neCell Cycle Checkpoints. Ukusebenza kokwelashwa komdlavuza, njenge-Dacarbazine, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Sesamin, esithinta i-Cell Cycle Checkpoints, kungase kungabi inketho efanele esimweni se-Primary Pulmonary artery intimal sarcoma lapho udlula e-Dacarbazine. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Ze-Sesamin zizozuzisa Iziguli Eziyinhloko ze-Glioblastoma ezelashwa nge-Temozolomide?

I-Glioblastoma eyinhloko ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TRBV7-7, TAS2R46 ne-TP53, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-JAK-STAT Signaling, Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, njengeTemozolomide, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Sesamin siyinketho enengqondo kulabo abane-Primary Glioblastoma abathola i-Temozolomide. Lokhu kungenxa yokuthi i-Sesamin ithonya izindlela ezifana ne-JAK-STAT Signaling, engavimbela izici ezishayela i-Primary Glioblastoma noma izuzise ukusebenza kahle kwe-Temozolomide.

3. Ingabe Izithasiselo Ze-Sesamin Ziphephile Kubantu Abanempilo Enempilo Nge-ERCC2 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ERCC2 luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ubungozi bomdlavuza.

Ukuguqulwa kofuzo lwe-ERCC2 kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, njenge-Cell Cycle Checkpoints kanye Nokulungiswa Kwe-DNA, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-ERCC2 oluhlobene nengozi eyengeziwe Yomdlavuza Wesikhumba, ukucabanga okungokwesayensi kuphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Sesamin. Lokhu kungenxa yokuthi isengezo se-Sesamin sithonya izindlela ezifana ne-Cell Cycle Checkpoints, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ERCC2 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Sesamin Ziphephile Kubantu Abanempilo Enempilo Nge-ALK Mutation Associated Genetic Risk?

I-ALK idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ALK kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa Ukusayina kwe-MAPK kanye ne-Growth Factor Signaling, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo ibonisa ukuguqulwa kwe-ALK ehlotshaniswa ne-Central Nervous System, cabanga ukufaka izithako ze-Sesamin ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-MAPK Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-ALK kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana neSesamin, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Izinguquko endleleni ye-p53 kanye nesisho se-p16INK4a zibikezela ukusinda okuphelele kweziguli ze-melanoma ze-metastatic ezilashwa nge-dacarbazine.
• cBioPortal for Cancer Genomics
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• I-Sesamin yenza ukuba kuboshwe umjikelezo weseli kanye ne-apoptosis ngokuvinjwa kwe-transducer yesiginali kanye ne-activator yokusayina kwe-transcription 3 kumugqa weseli we-hepatocellular carcinoma i-HepG2.
• I-RRAD ikhuthaza ukwenziwa kusebenze kwe-EGFR-mediated STAT3 futhi yenza ukumelana ne-temozolomide kwe-glioblastoma eyingozi.
• I-somatic genomic landscape ye-glioblastoma.
• Ukuvinjelwa kwe-programmed death ligand 1 (PD-L1) inkulumo kumaseli omdlavuza webele nge-sesamin.