Yimuphi umdlavuza ongazuza ngokufaka iSage ekudleni kwabo?

Amaphuzu avelele

I-Sage yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweSage ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Sage ingase izuze labo abanesifo se-Primary Rosai-Dorfman esiphethwe yi-Cladribine, kodwa ingase ingabi kuhle ezigulini ezithola i-Pembrolizumab ye-Primary Mucinous Stomach Adenocarcinoma. Ngaphezu kwalokho, nakuba i-Sage ingasiza abantu abanesici sengozi yofuzo "ERCC2", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "CALR". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Sage esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Sage iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neSage esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake iSage ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Sage uma unezakhi zofuzo zofuzo ezihambisana nofuzo lwe-ERCC2? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo isukela esakhiwo sofuzo se-CALR? Ingabe kunenzuzo ukufaka iSage ekudleni kwakho uma kutholakala ukuthi une-Primary Mucinous Stomach Adenocarcinoma, noma uma ukuxilongwa kwakho kuyisifo esiyi-Primary Rosai-Dorfman? Ngaphezu kwalokho, ukusebenzisa kwakho i-Sage kufanele kulungiswe kanjani uma welashelwa i-Cladribine noma uma uhlelo lwakho lokwelapha lusuka ku-Cladribine luye e-Pembrolizumab? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Sage ingokwemvelo, ngakho ihlale inenzuzo' noma 'I-Sage ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Sage ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Sage ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njengesifo esiwuhlobo oluyi-Primary Rosai-Dorfman noma i-Primary Mucinous Stomach Adenocarcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeSage. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-ERCC2 inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-CALR? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana nesifo se-Primary Rosai-Dorfman ilingana ne-Primary Mucinous Stomach Adenocarcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Pembrolizumab njengalabo abathola i-Cladribine? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Sage - Isengezo Somsoco

I-Sage eyengeziwe ihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Vitamin K, i-Vitamin B3, i-Ursolic Acid, i-Rosmarinic Acid ne-Oleic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MAPK Signaling, Interferon Signaling, JAK-STAT Signaling kanye neCell Cycle Checkpoints, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lemvelo, ukukhetha izithasiselo ezifanele njenge-Sage, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Sage yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweSage akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha i-Sage Supplements

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Sage endabeni Yomdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Sage kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Sage ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo Ze-Sage zizozuzisa Iziguli Eziyi-Primary Mucinous Stomach Adenocarcinoma ezelashwa nge-Pembrolizumab?

I-Primary Mucinous Stomach Adenocarcinoma ibonakala ngokuguqulwa kofuzo okuthile, okuyi-GRIN3A, TMEM26 kanye ne-TP53, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Interferon Signaling, i-Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, okufana ne-Pembrolizumab, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Sage, esithinta i-Interferon Signaling, kungenzeka kungabi yisinqumo esifanele esimweni se-Primary Mucinous Stomach Adenocarcinoma lapho uthola i-Pembrolizumab. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Ze-Sage zizozuzisa Iziguli ze-Primary Rosai-Dorfman Iziguli ezelashwa nge-Cladribine?

Isifo esiyisisekelo se-Rosai-Dorfman sikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-KRAS, MAP2K1 kanye ne-BARD1, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MAPK Signaling, i-G-protein-coupled Receptor Signaling, i-Growth Factor Signaling, i-Angiogenesis, i-RAS-RAF Signaling. kanye Nokulungiswa KweDNA. Ukusebenza kokwelashwa komdlavuza, njenge-Cladribine, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Sage siyindlela enengqondo kulabo abanesifo se-Primary Rosai-Dorfman ababhekene ne-Cladribine. Lokhu kungenxa yokuthi i-Sage ithonya izindlela ezifana ne-MAPK Signaling, engavimbela izici eziqhuba isifo se-Primary Rosai-Dorfman noma izuzise ukusebenza kahle kwe-Cladribine.

3. Ingabe Izithasiselo Ze-Sage Ziphephile Kubantu Abanempilo Enempilo Nge-CALR Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-CALR sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-CALR kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana ne-JAK-STAT Signaling kanye ne-Antigen Presentation, ezihileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba ukuguqulwa kwe-CALR okuhlobene nengozi eyengeziwe ye-Myeloproliferative Neoplasms, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo i-Sage. Lokhu kungenxa yokuthi ukwesekwa kwe-Sage kuthonya izindlela ezifana ne-JAK-STAT Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-CALR kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Sage Ziphephile Kubantu Abanempilo Enempilo Nge-ERCC2 Mutation Associated Genetic Risk?

I-ERCC2 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ERCC2 kungaphazamisa izindlela ezibalulekile zamakhemikhali ezinto eziphilayo, okuhlanganisa Izindawo Zokuhlola I-Cell Cycle kanye Nokulungiswa Kwe-DNA, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula uguquko ku-ERCC2 ehlotshaniswa nomdlavuza wesikhumba, cabanga ukufaka izithasiselo ze-Sage ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle Checkpoints, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-ERCC2 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana neSage, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• [Ukwelashwa ngokuhlinzwa kokulunywa okuvulekile].
• Ukusebenza kwe-deoxycytidine kinase ngama-protein kinase inhibitors kanye ne-okadaic acid kumaseli we-leukemic.
• I-Oleic acid yenza i-apoptosis kanye ne-autophagy ekwelapheni i-Tongue Squamous cell carcinomas.