Yimuphi umdlavuza ongazuza ngokufaka i-Resveratrol ekudleni kwabo?

Amaphuzu avelele

I-Resveratrol yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Resveratrol ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Resveratrol ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Fluorouracil ye-Primary Pediatric Hepatoblastoma. Ngaphezu kwalokho, ngenkathi i-Resveratrol ingasiza abantu abane-genetic risk factor "KMT2D", ingase ingaphakanyiswe kulabo abasengozini ehlukile yofuzo "ASXL1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Resveratrol yesiguli esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Resveratrol iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Resveratrol esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Resveratrol ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle i-Resveratrol uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-KMT2D? Kuthiwani uma esikhundleni salokho ubungozi bakho bofuzo busukela kufuzo lwe-ASXL1? Ingabe kunenzuzo ukufaka i-Resveratrol ekudleni kwakho uma kutholakala ukuthi une-Primary Pediatric Hepatoblastoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Resveratrol kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye ku-Fluorouracil? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Resveratrol ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Resveratrol ithuthukisa ukungatheleleki' azanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Resveratrol ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Resveratrol ekudleni kwakho ngezinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Pediatric Hepatoblastoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokudla okukhethwa kukho, njengeResveratrol. Ingabe ubungozi bofuzo lomdlavuza osukela ekuguqukeni kwe-KMT2D bunomthelela ofanayo we-biochemical pathway njengoguquko ku-ASXL1? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary Pediatric Hepatoblastoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Fluorouracil njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Resveratrol - Isengezo Sokudla Okunomsoco

Isithasiselo se-Resveratrol sihlanganisa uhla lwezithako ezisebenzayo, kufaka phakathi i-Resveratrol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Lipid Metabolism, i-Oncogenic Cancer Epigenetics, i-P53 Signaling kanye ne-DAP12 Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Resveratrol, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Resveratrol yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Resveratrol akusona isinqumo sendawo yonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Resveratrol

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Resveratrol esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Resveratrol ziyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Resveratrol ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo ze-Resveratrol zizozuzisa Iziguli Eziyisisekelo Ze-Hepatoblastoma Ezelashwa nge-Fluorouracil?

I-Hepatoblastoma Yezingane Eyisisekelo ibonakala ngokushintsha kofuzo okuthile, okuyi-CTNNB1, HUWE1 kanye ne-NFE2L2, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oncogenic Cancer Epigenetics, i-Adherens junction, i-Androgen Signaling, I-Oxidative Stress kanye Nezindawo Zokuhlola Amasosha omzimba. Ukusebenza kokwelashwa komdlavuza, okufana ne-Fluorouracil, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Resveratrol, esithinta i-Oncogenic Cancer Epigenetics, kungenzeka kungabi yisinqumo esifanele esimweni se-Primary Pediatric Hepatoblastoma lapho bethola i-Fluorouracil. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Resveratrol zizozizuzisa Iziguli Eziyinhloko ze-Penile Squamous Cell Carcinoma ezelashwa nge-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-Lipid Metabolism, i-Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Resveratrol siyinketho enengqondo kulabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Resveratrol ithonya izindlela ezifana ne-Lipid Metabolism, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kahle kwe-Mitomycin.

3. Ingabe Izithasiselo ze-Resveratrol Ziphephile Kubantu Abanempilo Nge-ASXL1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ASXL1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kwezakhi zofuzo ze-ASXL1 kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-P53 Signaling, i-Oncogenic Cancer Epigenetics kanye ne-Suppressive Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba uguquko ku-ASXL1 ehambisana nengozi eyengeziwe ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Resveratrol eyengeziwe. Lokhu kungenxa yokuthi ukwesekwa kwe-Resveratrol kuthonya izindlela ezifana ne-P53 Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ASXL1 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo ze-Resveratrol Ziphephile Kubantu Abanempilo Enempilo Nge-KMT2D Mutation Associated Genetic Risk?

I-KMT2D idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-KMT2D kungaphazamisa izindlela ezibucayi ze-biochemical, kuhlanganise ne-DAP12 Signaling kanye ne-Oncogenic Histone Methylation, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo ibonisa ukuguqulwa kwe-KMT2D ehambisana ne-Bladder Urothelial Carcinoma, cabanga ukufaka izithasiselo ze-Resveratrol ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-DAP12 Signaling, zizuze ngokuhlinzeka ngosekelo olufanele kubantu abanezinguquko ze-KMT2D kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Resveratrol, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Ukwenziwa okukhethiwe kanye nokuhlolwa kwezinto eziphilayo kwe-sulfate-conjugated resveratrol metabolites.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-Vorinostat Inamandla Okuhlanganisa I-5-Fluorouracil/Cisplatin Ngokuvimbela I-Chemotherapy-Induced EGFR Nuclear Translocation kanye Nokwandisa Ukutholwa kwe-Cisplatin.
• I-Resveratrol, inhibitor ephawulekayo ye-ribonucleotide reductase.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• [Inkulumo ye-Cyclooxygenase-2 kumaseli omdlavuza we-esophageal kanye nokungeniswa nge-mitomycin C].