Yimuphi umdlavuza ongahlomula ngokufaka i-Pterostilbene ekudleni kwabo?

Amaphuzu avelele

I-Pterostilbene yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Pterostilbene ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Pterostilbene ingase izuze labo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Sinonasal Adenocarcinoma. Ngaphezu kwalokho, ngenkathi i-Pterostilbene ingasiza abantu abanesici esiyingozi sofuzo “TERT”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Pterostilbene yesiguli esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Pterostilbene iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izakhi ezisebenzayo ekudleni/izithasiselo ezifana ne-Pterostilbene esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Pterostilbene ekudleni kwakho njengento yokudla noma isengezo? Kuyancomeka yini ukuthi udle i-Pterostilbene uma unezakhi zofuzo zomdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Pterostilbene ekudleni kwakho uma kutholakala ukuthi une-Primary Sinonasal Adenocarcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucinous colorectal adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Pterostilbene kufanele kulungiswe kanjani uma welashelwa i-Cetuximab noma uma uhlelo lwakho lokwelapha lusuka ku-Cetuximab luye kwiRadiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Pterostilbene ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Pterostilbene ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Pterostilbene ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Pterostilbene ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucinous colorectal adenocarcinoma noma i-Primary Sinonasal Adenocarcinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Pterostilbene. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-TERT inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucinous colorectal adenocarcinoma bulingana ne-Primary Sinonasal Adenocarcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Cetuximab? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Pterostilbene - Isengezo Sokudla Okunomsoco

Isengezo se-Pterostilbene sihlanganisa uhla lwezithako ezisebenzayo, kufaka phakathi i-Pterostilbene, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, Notch Signaling, Chromatin Remodeling and Cell Cycle, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Ngokunikezwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Pterostilbene, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Lapho ucubungula ukusebenzisa i-Pterostilbene yomdlavuza, kubalulekile ukuthi ucabangele lezi zici nezindlela ezahlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Pterostilbene akusona isinqumo sendawo yonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Pterostilbene

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Pterostilbene esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Pterostilbene kuyehluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Pterostilbene ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Pterostilbene Supplements izozizuzisa Iziguli Eziyinhloko ze-Sinonasal Adenocarcinoma ezelashwa ngeRadiation?

I-Primary Sinonasal Adenocarcinoma ibonakala ngokuguqulwa kofuzo okuthile, okuyi-ATRX, NOTCH1 kanye ne-PTPRD, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Notch Signaling kanye ne-RUNX Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Pterostilbene, esithinta i-Notch Signaling, kungase kungabi inketho elungile esimweni se-Primary Sinonasal Adenocarcinoma lapho i-Radiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Pterostilbene zizozizuzisa Iziguli Eziyinhloko ze-Mucinous colorectal adenocarcinoma ezelashwa nge-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TTN, i-APC ne-KRAS, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-MYC Signaling, i-Angiogenesis, i-G-protein-coupled Receptor Signaling kanye ne-Growth Factor Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Cetuximab, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Pterostilbene siyinketho enengqondo yalabo abane-Primary Mucinous colorectal adenocarcinoma ababhekana ne-Cetuximab. Lokhu kungenxa yokuthi i-Pterostilbene ithonya izindlela ezifana ne-MYC Signaling, engavimbela izici ezishayela i-Primary Mucinous colorectal adenocarcinoma noma izuzise ukusebenza kahle kwe-Cetuximab.

3. Ingabe Izithasiselo Ze-Pterostilbene Ziphephile Kubantu Abanempilo Enempilo Nge-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Cell Cycle kanye ne-DNA Repair, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula uguquko ku-TERT ehlotshaniswa ne-Hematological Cancer, cabanga ukufaka izithasiselo ze-Pterostilbene ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Pterostilbene, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Ukuqhathaniswa kwamaqembu lapho imiphumela isesikalini esihleliwe.
• cBioPortal for Cancer Genomics
• I-Notch eqondiwe ukuze inqobe ukumelana nemisebe.
• Ukudla kwe-pterostilbene, okuyingxenye yamajikijolo aluhlaza, kuvimbela indlela yokubonisa i-beta-catenin/p65 eyehla nomfula kanye ne-colon carcinogenesis kumagundane.
• I-Pterostilbene yenza umsebenzi we-antitumor ngendlela yokubonisa i-Notch1 kumaseli wamaphaphu e-adenocarcinoma.
• I-Pterostilbene ilawula phansi i-hTERT ekugxilweni komzimba kumaseli omdlavuza webele: Ngokunokwenzeka ngokuvinjwa kwe-cMyc.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• cBioPortal for Cancer Genomics
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.