Yimuphi umdlavuza ongazuza ngokufaka iPomegranate ekudleni kwabo?

Amaphuzu avelele

Ipomegranate yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwePomegranate ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, iPomegranate ingase izuze labo abane-Primary Solitary Fibrous Tumor abathola i-Avastin, kodwa kungase kungabi kuhle ezigulini ezithola i-Cisplatin ye-Primary Head and Neck Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba iPomegranate ingasiza abantu abanesici sengozi yofuzo "ERBB2", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ERCC2". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwePomegranate esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi iPomegranate iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana nePomegranate esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake iPomegranate ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle iPomegranate uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ERBB2? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-ERCC2? Ingabe kunenzuzo ukufaka iPomegranate ekudleni kwakho uma kutholakala ukuthi une-Primary Head and Neck Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ukusetshenziswa kwakho kwePomegranate kufanele kulungiswe kanjani uma welashwa nge-Avastin noma uma uhlelo lwakho lokwelapha lusuka ku-Avastin luye eCisplatin? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'Ipomegranati ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'Ipomegranate ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka iPomegranate ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana nePomegranate ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Solitary Fibrous Tumor noma i-Primary Head and Neck Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka kanye ubulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengePomegranate. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-ERBB2 inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ERCC2? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Solitary Fibrous Tumor ilingana ne-Primary Head and Neck Squamous Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Cisplatin njengalabo abathola i-Avastin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Igromegranate – Isengezo Esinomsoco

Isithasiselo sePomegranate sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Octadecanoic Acid, i-Hexadecanoic Acid, i-Betulinic Acid, i-Casuarinin ne-Ursolic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling kanye neChromatin Remodeling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengePomegranate, iyodwa noma ihlangene, iba yisinqumo esibalulekile kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa iPomegranate ngomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwePomegranate akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako zePomegranate

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme ihalananda esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo zePomegranate kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezinjengohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi iPomegranate ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo zePomegranate zizozuzisa Iziguli Eziyinhloko Nentamo I-squamous Cell Carcinoma ezelashwa nge-Cisplatin?

I-Primary Head and Neck Squamous Cell Cell Carcinoma ibonakala ngokuguquka kwezakhi zofuzo ezithile, okuyi-FRG1BP, TP53 ne-PCDH11X, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-Epithelial to Mesenchymal Transition, Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, okufana ne-Cisplatin, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo sePomegranate, esithinta i-Epithelial kuya ku-Mesenchymal Transition, kungase kungabi inketho efanele esimweni se-Primary Head kanye ne-Neck Squamous Cell Carcinoma lapho uthatha i-Cisplatin. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo zePomegranati zizozizuzisa Iziguli Eziyinhloko Zodwa Ezine-Fibrous Tumor ezilashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-BRD4, FLI1 kanye ne-KMT2C, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Avastin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo sePomegranate siyindlela enengqondo yalabo abane-Primary Solitary Fibrous Tumor ababhekana ne-Avastin. Lokhu kungenxa yokuthi Ihalananda lithonya izindlela ezifana ne-MYC Signaling, engavimbela izici ezishayela I-Primary Solitary Fibrous Tumor noma izuzise ukusebenza kahle kwe-Avastin.

3. Ingabe Izithasiselo Zepomegranate Ziphephile Kubantu Abanempilo Enempilo Ene-ERCC2 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ERCC2 luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ubungozi bomdlavuza.

Ukuguqulwa kofuzo lwe-ERCC2 kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-PI3K-AKT-MTOR Signaling and DNA Repair, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-ERCC2 oluhlobene nengozi eyengeziwe Yomdlavuza Wesikhumba, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo sePomegranate. Lokhu kungenxa yokuthi isengezo sePomegranate sithonya izindlela ezifana ne-PI3K-AKT-MTOR Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ERCC2 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Zepomegranati Ziphephile Kubantu Abanempilo Enempilo Ene-ERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-ERBB2 kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Chromatin Remodeling, i-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula ukuguqulwa kwezakhi zofuzo ku-ERBB2 ehambisana ne-Esophageal Adenocarcinoma, cabanga ukufaka izithako zePomegranate ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Chromatin Remodeling, zizuze ngokunikeza usekelo olufanele kubantu abanokuguqulwa kwe-ERBB2 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana nePomegranate, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Ukungeniswa kokuboshwa komjikelezo wamaseli kanye ne-apoptosis kumdlavuza wamaphaphu ongewona omncane wamaseli we-A549 ngamaseli we-casuarinin ovela egxolweni le-Terminalia arjuna Linn.
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekumelaneni ne-anti-angiogenic therapy.