Imuphi umdlavuza ongahlomula ngokufaka uphayinaphu ekudleni kwabo?

Amaphuzu avelele

Uphayinaphu waziwa kabanzi ngezinzuzo zawo zezempilo futhi uvame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kukaPhayinaphu ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, uphayinaphu ungase uzuze labo abane-Primary Solitary Fibrous Tumor abathola i-Avastin, kodwa kungase kungabi kuhle ezigulini ezithola i-Docetaxel ye-Primary Cervical Neuroendocrine Tumor. Ngaphezu kwalokho, nakuba uphayinaphu ungasiza abantu abanengozi yofuzo “TERT”, kungenzeka ungaphakanyiselwa labo abasengozini yofuzo ehlukile ethi “ALK”. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kukaPhayinaphu esigulini somdlavuza kudinga ukuthi kube nomuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi uPhayinaphu uyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana nophayinaphu esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uyaphakama: Ingabe kufanele uhlanganise uphayinaphu ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle uphayinaphu uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ALK? Ingabe kunenzuzo ukufaka uphayinaphu ekudleni kwakho uma kutholakala ukuthi une-Primary Cervical Neuroendocrine Tumor, noma uma ukuxilongwa kwakho kuyi-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ukusetshenziswa kwakho kukaphayinaphu kufanele kulungiswe kanjani uma welashwa nge-Avastin noma uma uhlelo lwakho lokwelapha lusuka ku-Avastin luye ku-Docetaxel? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'Uphayinaphu ungokwemvelo, ngakho uhlezi uzuzisa' noma 'Uphayinaphu uthuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka uphayinaphu ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana nophayinaphu ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Solitary Fibrous Tumor noma Primary Cervical Neuroendocrine Tumor, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokudla okukhethwa kukho, njengophayinaphu. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-TERT inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ALK? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Solitary Fibrous Tumor ilingana ne-Primary Cervical Neuroendocrine Tumor? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Docetaxel njengalabo abathola i-Avastin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Uphayinaphu – Isengezo Esinomsoco

Uphayinaphu oyisithako uhlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-4-aminobutyric Acid, Glycine, L-leucine, Retinol kanye neFerulic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, i-DNA Repair kanye ne-P53 Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengophayinaphu, uwodwa noma uhlangene, kuba yisinqumo esibalulekile kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa uphayinaphu umdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufanayo nokwelapha umdlavuza, ukusetshenziswa kukaphayinaphu akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa umuntu siqu.

Ukukhetha Izithasiselo zikaphayinaphu

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiwugweme yini uphayinaphu esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo zikaphayinaphu kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithasiselo ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi uphayinaphu ufanelekile noma kufanele ugwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo zikaphayinaphu zizozizuzisa Iziguli Eziyinhloko Ze-Cervical Neuroendocrine Tumor ezelashwa nge-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ibonakala ngokuguquguquka okuthile kofuzo, okuyi-ABHD6, STOX1 kanye ne-PDZD4, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-MYC Signaling. Ukusebenza kokwelashwa komdlavuza, okufana ne-Docetaxel, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo sikaphayinaphu, esithinta Ukusayinwa kwe-MYC, kungase kungabi inketho efanele esimweni se-Primary Cervical Neuroendocrine Tumor lapho uthola i-Docetaxel. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo zikaphayinaphu zizozizuzisa Iziguli Eziyisisekelo Zodwa Ezine-Fibrous Tumor ezilashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-BRD4, FLI1 kanye ne-KMT2C, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Avastin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo sikaphayinaphu siyindlela enengqondo yalabo abane-Primary Solitary Fibrous Tumor abathola i-Avastin. Lokhu kungenxa yokuthi uphayinaphu uthonya izindlela ezifana ne-MYC Signaling, engavimbela izici eziqhuba I-Primary Solitary Fibrous Tumor noma izuzise ukusebenza kahle kwe-Avastin.

3. Ingabe Izithako zikaphayinaphu Ziphephile Kubantu Abanempilo Enempilo Ene-ALK Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-ALK sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ALK kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana nokulungiswa kwe-DNA kanye ne-Growth Factor Signaling, ezihileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba ukuguquka kwezakhi zofuzo ku-ALK okuhlobene nengozi eyengeziwe Yesistimu Yezinzwa Emaphakathi, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kophayinaphu. Lokhu kungenxa yokuthi isengezo sikaphayinaphu sinomthelela ezindleleni ezifana nokulungiswa kwe-DNA, okungaholela emiphumeleni emibi esimweni soguquko lwe-ALK kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithako zikaphayinaphu Ziphephile Kubantu Abanempilo Enempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-P53 Signaling kanye ne-DNA Repair, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ehambisana Nomdlavuza Wegazi, cabanga ukufaka izithasiselo zikaphayinaphu ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-P53 Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana nophayinaphu, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• I-Selumetinib Plus I-Docetaxel Iqhathaniswa Ne-Docetaxel Yodwa kanye Nokusinda Okungathuthuki Ezigulini Ezinomdlavuza we-KRAS-Mutant Othuthukile Ongewona Owomncane Wengqamuzana Wamaphaphu: Ukuhlolwa Komtholampilo Okukhethekile Oku-KHETHA-1 Okungahleliwe.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• Imiphumela ye-anticancer ye-ferulic acid ihlotshaniswa nokungeniswa kokuboshwa komjikelezo weseli kanye ne-autophagy kumaseli omdlavuza womlomo wesibeletho.
• I-genomics yomtholampilo edidiyelwe yomdlavuza we-metastatic.
• I-Legionella pneumophila serogroup 12 pneumonia kumamukeli wokufakelwa kwezinso: umbiko wecala kanye nokubhekwa kwemvelo.
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekumelaneni ne-anti-angiogenic therapy.