Imuphi umdlavuza ongazuza ngokufaka uPedra ekudleni kwabo?

Amaphuzu avelele

I-Pedra yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwePedra ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, ukwelashwa ngamakhemikhali, okunye ukwelashwa, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Pedra ingase izuze labo abane-Primary Stomach Adenocarcinoma abathola i-Oxaliplatin, kodwa kungase kungabi kuhle ezigulini ezithola i-Trifluridine ye-Primary Stomach signet ring cell carcinoma. Ngaphezu kwalokho, nakuba i-Pedra ingasiza abantu abanesici esiyingozi sofuzo "ALK", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "KMT2D". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwePedra esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Pedra iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Pedra esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake iPedra ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Pedra uma unezakhi zofuzo zofuzo ezihambisana nofuzo lwe-ALK? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo isuka kufuzo lwe-KMT2D? Ingabe kunenzuzo ukufaka i-Pedra ekudleni kwakho uma kutholakala ukuthi une-Primary Stomach signet ring cell carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Stomach Adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Pedra kufanele kulungiswe kanjani uma welashelwa i-Oxaliplatin noma uma uhlelo lwakho lokwelapha lusuka ku-Oxaliplatin luye e-Trifluridine? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Pedra ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Pedra ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Pedra ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokuhlanganisa ukudla noma izithasiselo ezifana ne-Pedra ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Stomach Adenocarcinoma noma i-Primary Stomach signet ring cell carcinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengePedra. Ingabe ingozi yofuzo yomdlavuza obangelwa uguquko ku-ALK inemithelela efanayo ye-biochemical pathway njengoguquko ku-KMT2D? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Stomach Adenocarcinoma ilingana ne-Primary Stomach signet ring cell carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Trifluridine njengalabo abathola i-Oxaliplatin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Pedra – Isengezo Sokudla Okunomsoco

Isithasiselo sePedra sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Myrcene, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi Ukulungiswa kabusha kwe-Extracellular Matrix, i-TGFB Signaling kanye ne-MAPK Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Pedra, iyodwa noma ihlangene, kuba yisinqumo esibalulekile esimweni sokudla komdlavuza. Uma ucabangela ukusebenzisa i-Pedra yomdlavuza, kubalulekile ukucabangela lezi zici ezihlukahlukene kanye nezinqubo. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwePedra akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Pedra Izithako

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Pedra endabeni Yomdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo zePedra kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Pedra ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Pedra Supplements izozuza I-Primary Stomach signet ring cell carcinoma Iziguli ezelashwa nge-Trifluridine?

I-Primary Stomach signet ring cell carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-TTN, CSMD1 kanye ne-SLITRK2, okuholela ekuguqulweni kwezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi Ukusayina kwe-TGFB. Ukusebenza kokwelashwa komdlavuza, njenge-Trifluridine, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isengezo se-Pedra, esithinta i-TGFB Signaling, ingase ingabi inketho efanele esimweni se-Primary Stomach signet ring cell carcinoma lapho uphathwa i-Trifluridine. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Pedra zizozizuzisa Iziguli ze-Adenocarcinoma Yesisu Esiyinhloko ezelashwa nge-Oxaliplatin?

I-Primary Stomach Adenocarcinoma ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-TP53, TTN kanye ne-PEG3, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi Ukulungiswa kabusha kwe-Extracellular Matrix, I-Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, njenge-Oxaliplatin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Pedra siyinketho enengqondo kulabo abane-Primary Stomach Adenocarcinoma abathola i-Oxaliplatin. Lokhu kungenxa yokuthi i-Pedra ithonya izindlela ezifana ne-Extracellular Matrix Remodelling, engavimbela izici eziqhuba i-Primary Stomach Adenocarcinoma noma izuzise ukusebenza kahle kwe-Oxaliplatin.

3. Ingabe Izithasiselo ZePedra Ziphephile Kubantu Abanempilo Enempilo Nge-KMT2D Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-KMT2D luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kwezakhi zofuzo ze-KMT2D kuthinta izindlela ze-biochemical noma izinqubo, njenge-Extracellular Matrix Remodeling kanye ne-Oncogenic Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-KMT2D oluhlobene nengozi eyengeziwe ye-Bladder Urothelial Carcinoma, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Pedra eyengeziwe. Lokhu kungenxa yokuthi isengezo se-Pedra sithonya izindlela ezifana ne-Extracellular Matrix Remodelling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-KMT2D kanye nezimo zomdlavuza ezihlobene.

4. Ingabe I-Pedra Supplements Iphephile Kubantu Abanempilo Enempilo Ene-ALK Mutation Associated Genetic Risk?

I-ALK idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ALK kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa Ukusayina kwe-MAPK kanye ne-Growth Factor Signaling, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-ALK ehambisana ne-Central Nervous System, cabanga ukufaka izithasiselo ze-Pedra ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-MAPK Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-ALK kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Pedra, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Iqhaza le-MMP7 kanye nenkulumo-mpikiswano yayo nohlelo lwe-FAS/FASL ngesikhathi sokutholwa kwe-chemoresistance ku-oxaliplatin.
• Indlela ye-TGF-β yenziwa isebenze ukwelashwa kwe-5-fluorouracil kumaseli e-colorectal carcinoma angazweli emthini.
• cBioPortal for Cancer Genomics
• Isici esiphelele samangqamuzana e-gastric adenocarcinoma.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• I-Myrcene, i-Aromatic Volatile Compound, Ithuthukisa Ukuguga Kwangaphandle Kwesikhumba Somuntu Ngokulawulwa Kokukhiqizwa Kwe-MMPs.