Yimuphi umdlavuza ongazuza ngokufaka i-Mint ekudleni kwabo?

Amaphuzu avelele

I-Mint yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Mint yeziguli ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Mint ingase izuze labo abane-Primary Myxoid Chondrosarcoma abathola i-Dactinomycin, kodwa ingase ingabi yinhle ezigulini ezithola i-Radiation for Primary Urethral Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba i-Mint ingasiza abantu abanesici sengozi yofuzo "i-ATM", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "CTNNB1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Mint yesiguli somdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Mint iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Mint esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Mint ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle i-Mint uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ATM? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-CTNNB1? Ingabe kunenzuzo ukufaka i-Mint ekudleni kwakho uma kutholakala ukuthi une-Primary Urethral Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Myxoid Chondrosarcoma? Ngaphezu kwalokho, ukusetshenziswa kwakho kweMint kufanele kulungiswe kanjani uma welashwa nge-Dactinomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Dactinomycin luye kuMisebe? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Mint ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Mint ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Mint ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Mint ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Myxoid Chondrosarcoma noma i-Primary Urethral Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njenge-Mint. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-ATM inemithelela efanayo ye-biochemical pathway njengoguquko ku-CTNNB1? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Myxoid Chondrosarcoma ilingana ne-Primary Urethral Squamous Cell Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Dactinomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Mint - Isengezo Somsoco

Isithasiselo se-Mint sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Apigenin, i-Vitamin C, i-Trans-trans-farnesol, i-Rosmarinic Acid ne-Vitamin A, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Apoptosis, i-RAS-RAF Signaling, i-NFKB Signaling kanye ne-MYC Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Mint, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Mint yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Mint akusona isinqumo sendawo yonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako ze-Mint

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Mint esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Mint ziyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Mint ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo ze-Mint zizosizakala Iziguli Eziyinhloko ze-Urethral Squamous Cell Carcinoma ezelashwa ngeRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-BLM, i-BRCA1 ne-CTCF, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-RAS-RAF Signaling, i-Androgen Signaling kanye nokulungiswa kwe-DNA. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Mint, esithinta i-RAS-RAF Signaling, singase singabi yisinqumo esifanele esimweni se-Primary Urethral Squamous Cell Carcinoma lapho sibhekene Nokukhishwa Kwemisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithako Ze-Mint Zizosiza Iziguli Eziyinhloko ze-Myxoid Chondrosarcoma ezelashwa nge-Dactinomycin?

I-Myxoid Chondrosarcoma eyinhloko ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-IDH1, i-NR2E1 ne-WDFY4, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Apoptosis, i-Oncogenic Cancer Epigenetics kanye ne-Glutathione Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Dactinomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isengezo se-Mint siyindlela enengqondo kulabo abane-Primary Myxoid Chondrosarcoma abathola i-Dactinomycin. Lokhu kungenxa yokuthi i-Mint ithonya izindlela ezifana ne-Apoptosis, engavimbela izici ezishayela i-Primary Myxoid Chondrosarcoma noma izuzise ukusebenza kahle kwe-Dactinomycin.

3. Ingabe Izithako Ze-Mint Ziphephile Kubantu Abanempilo Enempilo Nge-CTNNB1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-CTNNB1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kofuzo lwe-CTNNB1 kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana ne-NFKB Signaling, Adherens junction kanye ne-Epithelial to Mesenchymal Transition, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza ukuguqulwa kwezakhi zofuzo ku-CTNNB1 okuhlobene nengozi eyengeziwe ye-Adrenocortical Carcinoma, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-supplement Mint. Lokhu kungenxa yokuthi isengezo se-Mint sithonya izindlela ezifana ne-NFKB Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-CTNNB1 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Mint Ziphephile Kubantu Abanempilo Enempilo Nge-ATM Mutation Associated Genetic Risk?

I-ATM idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ATM kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-MYC Signaling kanye ne-DNA Repair, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-ATM ezihlotshaniswa ne-Chronic Myelomonocytic Leukemia, cabanga ukufaka izithako ze-Mint ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-MYC Signaling, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanokuguqulwa kwe-ATM kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Mint, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-Palaeonthropology. Isikhathi samaNeanderthal okugcina.
• cBioPortal for Cancer Genomics
• Ukuhlaziywa kwensimu yamangqamuzana okuqhathanisa nama-flavonoid inhibitors we-PIM-1 kinase.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Ama-Flavonoids njengama-receptor tyrosine kinase FLT3 inhibitors.
• Umthelela we-oncogenic K-RAS ku-YB-1 phosphorylation edalwe imisebe ye-ionizing.
• Ubudlelwano bomsebenzi wesakhiwo-proteasome-inhibitory we-flavonoid yokudla kumaseli omdlavuza womuntu.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• Ukutholwa kwama-flavone angaziwa njengama-inhibitor we-NF-κB ukusayina kumaseli omdlavuza webele we-MDA-MB-231-Ucwaningo lwe-SAR.