Yimuphi umdlavuza ongahlomula ngokufaka i-Maclura Pomifera ekudleni kwabo?

Amaphuzu avelele

I-Maclura Pomifera yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Maclura Pomifera ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Maclura Pomifera ingase izuze labo abane-Primary Uterine Undifferentiated Carcinoma abathola i-Letrozole, kodwa kungase kungabi kuhle ezigulini ezithola i-Vemurafenib ye-Primary Erdheim Chester Disease. Ngaphezu kwalokho, nakuba i-Maclura Pomifera ingasiza abantu abanesici esiyingozi sofuzo "TERT", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ALK". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Maclura Pomifera esigulini somdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Maclura Pomifera iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Maclura Pomifera esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Maclura Pomifera ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Maclura Pomifera uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ALK? Ingabe kunenzuzo ukufaka i-Maclura Pomifera ekudleni kwakho uma kutholakala ukuthi une-Primary Erdheim Chester Disease, noma uma ukuxilongwa kwakho kuyi-Primary Uterine Undifferentiated Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Maclura Pomifera kufanele kulungiswe kanjani uma welashwa nge-Letrozole noma uma uhlelo lwakho lokwelapha lusuka ku-Letrozole luye e-Vemurafenib? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'Maclura Pomifera kungokwemvelo, ngakho-ke kuhlale kunenzuzo' noma 'i-Maclura Pomifera ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Maclura Pomifera ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Maclura Pomifera ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Uterine Undifferentiated Carcinoma noma I-Primary Erdheim Chester Disease, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokudla okukhethwa kukho, okufana ne-Maclura Pomifera. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-TERT inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ALK? Ngokombono wokudla okunomsoco, ingabe ingozi ehambisana ne-Primary Uterine Undifferentiated Carcinoma ilingana ne-Primary Erdheim Chester Disease? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Vemurafenib njengalabo abathola i-Letrozole? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Maclura Pomifera – Isengezo Esinomsoco

Isengezo i-Maclura Pomifera sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Morin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-WNT Beta Catenin Signaling, i-MAPK Signaling, i-MYC Signaling kanye ne-P53 Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Maclura Pomifera, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Maclura Pomifera yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Maclura Pomifera akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Maclura Pomifera

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Maclura Pomifera esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Maclura Pomifera ziyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Maclura Pomifera ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe I-Maclura Pomifera Supplements izozizuzisa Iziguli Eziyinhloko Zesifo Se-Erdheim Chester ezelashwa nge-Vemurafenib?

Isifo se-Erdheim Chester Esiyisisekelo sibonakala ngokuguqulwa okuthile kofuzo, okuyi-MAP2K1, ARAF kanye ne-ARID5B, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Angiogenesis, i-RAS-RAF Signaling, i-MAPK Signaling kanye ne-Suppressive Histone Methylation. Ukusebenza kokwelashwa komdlavuza, njenge-Vemurafenib, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Maclura Pomifera, esithinta Ukusayinwa kwe-MAPK, kungase kungabi inketho efanele esimweni se-Primary Erdheim Chester Disease lapho uphathwa i-Vemurafenib. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Maclura Pomifera Supplements izozuza Iziguli Eziyinhloko Ze-Uterine Undifferentiated Carcinoma ezelashwa nge-Letrozole?

I-Primary Uterine Undifferentiated Carcinoma ibonakala ngokuguqulwa kwezakhi zofuzo ezithile, njenge-KMT2C, TP53 kanye ne-NSD1, okuholela ekushintsheni kwezindlela ze-biochemical, ikakhulukazi i-WNT Beta Catenin Signaling, i-Oncogenic Histone Methylation, i-Amino Acid Metabolism, I-Cell Cycle Checkpoints, i-Apoptosis ne-Chromatin Remodeling. Ukusebenza kokwelashwa komdlavuza, njengeLetrozole, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isengezo se-Maclura Pomifera siyinketho enengqondo yalabo abane-Primary Uterine Undifferentiated Carcinoma ababhekana ne-Letrozole. Lokhu kungenxa yokuthi i-Maclura Pomifera ithonya izindlela ezifana ne-WNT Beta Catenin Signaling, engavimbela izici ezishayela i-Primary Uterine Undifferentiated Carcinoma noma izuzise ukusebenza kahle kwe-Letrozole.

3. Ingabe Izithasiselo ze-Maclura Pomifera Ziphephile Kubantu Abanempilo Ene-ALK Mutation Ehlobene Nengozi Yofuzo?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-ALK sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ALK kuthinta izindlela noma izinqubo zamakhemikhali ezinto eziphilayo, njenge-MYC Signaling and Growth Factor Signaling, ezihileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza ukuguqulwa kwezakhi zofuzo ku-ALK okuhlobene nengozi eyengeziwe Yesistimu Yezinzwa Emaphakathi, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Maclura Pomifera. Lokhu kungenxa yokuthi isengezo se-Maclura Pomifera sithonya izindlela ezifana ne-MYC Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ALK kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo ze-Maclura Pomifera Ziphephile Kubantu Abanempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-P53 Signaling kanye ne-DNA Repair, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ehambisana Nomdlavuza Wegazi, cabanga ukufaka izithasiselo ze-Maclura Pomifera ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-P53 Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Maclura Pomifera, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-Morin Ivimbela Ukusabalala, Ukufuduka, kanye Nokuhlasela Komdlavuza Wesinye EJ Amangqamuzana Ngokuguquguquka Kwezindlela Zokusayina, Izilawuli ze-Cell Cycle, kanye ne-Transcription Factor-Mediated MMP-9 Expression.
• Ama-mammospheres amaseli omdlavuza webele amelana ne-letrozole athuthukisa ulaka lomdlavuza webele.
• Ukuqonda Kwesakhiwo Ekusebenzisaneni Phakathi Kwamaprotheni Ahlobene Nokufa Kinase 1 kanye nama-Flavonoids Emvelo.
• cBioPortal for Cancer Genomics
• Ukuhlelwa kabusha kwe-Dynamic kwe-kinome ekuphenduleni ekuvinjweni kwe-MEK okuhlosiwe kumdlavuza webele one-triple-negative.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• Ukwelashwa okuhlanganisiwe nge-flavonoid morin ne-telomerase inhibitor MST-312 kunciphisa izici zomdlavuza we-stem cell ngokukhomba i-STAT3 ne-telomerase.